| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Johansson, Amanda, et al.
(author)
-
Stability and immunoreactivity of the monoclonal anticytokeratin antibody TS1 after different degrees of iodination.
- 1999
-
In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 329-334
-
Journal article (peer-reviewed)abstract
- The immunoreactivity, stability and in vivo kinetics of an anticytokeratin 8 monoclonal antibody, TS1, were investigated following different degrees of labeling with 125I (0.2, 1 and 2-3 125I/TS1 MAb). By testing with ELISA, it was demonstrated that a high degree of iodination, i.e. > 2 125I/TS1, caused a rapid decrease in immunoreactivity to almost zero within 10 days. Furthermore, a complete degradation to low molecular weight fragments and free iodine was seen, as shown by SDS PAGE and autoradiography. The differently labeled radionuclide conjugates were injected into nude mice inoculated with HeLa Hep2 cells and tumor doses (estimated by MIRD formalism), tumor:non-tumor dose ratios, % I.D./gram tissue, Gy/MBq and in vivo kinetics of the differently labeled MAbs were determined. Despite the in vitro instability of the highest iodinated radionuclide conjugate, it was possible to deliver high doses to the tumors if the conjugate was injected into the animal immediately after completion of the iodination procedure. Increases from 1.4 Gy to 15.2 Gy delivered tumor dose were obtained with a tenfold increase in the specific activity, without alterations in the tumor:non-tumor tissue dose ratios. There is room for significant improvements in efficacy at radioimmunotherapy, which can be gained by optimizing the degree of iodination. For therapeutical applications a high degree of iodination may be an advantage.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Collin, Sven-Olof, et al.
(author)
-
Market Segmentation in Scientific Publications : Research Patterns in American vs European Management Journals
- 1996
-
In: British Journal of Management. - Chichester : Wiley-Blackwell. - 1045-3172 .- 1467-8551. ; 7:2, s. 141-154
-
Journal article (peer-reviewed)abstract
- Ideal science should conform to certain criteria or goals, among them the goals of universalism and commonality. Realization of these goals may be limited, however, through the dividing up of researchers in terms of geographical borders. In this study the general hypothesis is tested that there is a segmentation of the society of management researchers into a North American (US) and a European (E) segment, a segmentation which is furthered by differences in incentive schemes and in paradigms. Four leading management journals from North America and from Europe, respectively, and the 242 articles they contained published in 1993 were selected to represent the different geographical segments. The results provide: support for the existence of two such segments; support for differences in incentive schemes influencing the articles; support for their being paradigm differences between the two segments; and support for a paradigm effect being stronger in US-journals than in E-journals, US-authors are more willing, however, to conform to the E-paradigm than vice versa. We argue for methodological pragmatism in order to reduce the presumed counter-productive effects of paradigmatic rigidity.
|
|
| 10. |
- Gradin, Per A., et al.
(author)
-
Measurement of the Power Distribution in a Single Disc Refiner
- 1999
-
In: Journal of Pulp and Paper Science. - 0826-6220. ; 25:11, s. 384-387
-
Journal article (peer-reviewed)abstract
- A vital parameter in the production of mechanical pulp through refining is the energy consumption. Until recently, the pulping industry has focused on the total energy consumed, without a full understanding of how this energy is distributed in the refiners. In this paper two methods are suggested by which it is possible to estimate the energy supplied at an arbitrary point along the disc radius on refiner segments. The methods are based on instrumented bar with strain gauges. In the first method, a bar is slotted so that the sensor can be viewed as consisting of a number of cantilever beams separated by slots. In the second method, the sensor consists of one continuous bar along the disc radius. The sensors are calibrated such that influence coefficients are obtained for the slotted case and an influence function is obtained for the continuous one. The tangential forces are obtained directly in the first method, while in the second they are given by an integral equation which can be solved numerically. From the knowledge of the tangential force the power distribution can be calculated. Experimental results from the use of the slotted sensor are also given.
|
|
