| 1. |
- Dou, S.X., et al.
(author)
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Improvement of critical current density in the Bi-Pb-Sr-Ca-Cu-O system through hot isostatic pressing
- 1990
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In: Physica. C, Superconductivity. - 0921-4534 .- 1873-2143. ; 167:5-6, s. 525-528
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Journal article (peer-reviewed)abstract
- The effects of hot isostatic pressing (HIPing) on densification and the superconducting properties of the Bi-Pb-Sr-Ca-O system were investigated. A relative density up to 95% and a critical current density greater than 1100 A/cm2 at 77 K were achieved through HIPing at 650°C for 2 h under 200 MPa argon. Under these conditions, the product gave a value of Jc four times that without HIPing. To was unaffected by HIPing for samples encapsulated with a combination of glass and silver tubes. However, To was suppressed from 103 K to 86 K for samples encapsulated with stainless steel and silver tubes while Jc increased from 260 A/ cm2 to 1086 A/cm2 during HIPing, indicating that the weak links were significantly improved. A new minor phase, having a composition of Bi/Pb/Sr/Ca/Cu=0.58/2.8/3.0/2.1/1.1, was observed in HIPed samples but its effect on Jc is not clear
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| 2. |
- Borrow, Julian, et al.
(author)
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Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts
- 1992
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 82:3, s. 529-540
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Journal article (peer-reviewed)abstract
- Acute promyelocytic leukaemia (APL; AML M3) is identified by a unique t(15;17) translocation which fuses the PML gene to the retinoic acid receptor alpha gene (RARA). Reverse transcription coupled with the polymerase chain reaction (RT-PCR) has been used to develop a diagnostic test for APL based on the PML-RARA fusion message. Separate PCR assays were designed to amplify either PML-RARA (15q+ derived) or RARA-PML (17q- derived) chimaeric transcripts. PML-RARA transcripts were detected in every case from a series of 18 APL patients with cytogenetically confirmed t(15;17) translocations, whereas RARA-PML messages were detected in only 67% (12/18) of these patients. This suggests that it is the 15q+ derivative which mediates leukaemogenesis. Furthermore the PCR approach (or Southern analysis) may be used to identify in which of the alternative PML introns the breakpoint occurs; 52% of cases (15/29 patients) utilize a 5' PML intron and 48% the 3' intron (14/29 cases). Neither the choice of PML intron nor the expression of the 17q- derivative could be correlated with the microgranular variant of APL (M3V), overall survival rate, age, sex or presence of coagulopathy. Finally, the fusion message is undetectable in five remission samples. This indicates a possible use for RT-PCR in monitoring remission patients for evidence of relapse.
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| 3. |
- Carney III, John F, et al.
(author)
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Side impact crash testing of highway safety hardware
- 1991
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In: Proceedings of Strategic Highway Research Program and Traffic Safety on Two Continents. Conference in Gothenburg, Sweden, September 18-20, 1991. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 25-42
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Conference paper (other academic/artistic)
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| 4. |
- Gaillard, Marie-Jose, et al.
(author)
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A late Holocene record of land-use history, soil erosion, lake trophy and lake-level fluctuations at Bjäresjösjön (South Sweden) changes in southern Sweden
- 1991
-
In: Journal of Paleolimnology. - 0921-2728 .- 1573-0417. ; 6, s. 51-81
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Journal article (peer-reviewed)abstract
- Land-use history, soil ersosion, lake trophy and lake-level fluctuations during the last 3000 years werereconstructed through a multidisciplinary palaeolimnological study (pollen, plant macrofossils, diatoms,physical and chemical analysis, magnetic measurements and radiometric methods) of a small eutrophiclake in southern Sweden (Bj~resjOsjOn, Scania). There are striking responses in diatom, chemical,sediment yield and magnetic records to land-use changes documented by pollen analysis or historicalsources, and to lake-level changes identified from sedimentary changes. Our multidisciplinary approachassists interpretation of the processes controlling long-term changes and separation of the effects ofdifferent factors (land-use changes, lake-level fluctuations) on individual biostratigraphical records.Climate has controlled processes in the lake indirectly, through lake-level fluctuations, from the LateBronze Age to the Viking Age (700 BC-AD 800). Since the Viking Age, land-use controlled most of thechanges observed in the lake's development and soil erosion processes. Major changes in lake developmentoccurred during the last 200 years, due to a drastic increase in soil erosion and water eutrophicationduring a period of agricultural modernization.
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| 5. |
- Gaillard, Marie-Jose, et al.
(author)
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A multidisciplinary study of Lake Bjäresjö (S Sweden): land-use history, soil erosion, lake trophy and lake-level fluctuations during the last 3000 years
- 1991
-
In: Hydrobiologia. - 0018-8158 .- 1573-5117. ; 214, s. 107-114
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Journal article (peer-reviewed)abstract
- The lake Bjaresjosjon, Southern Scania, Southern Sweden, was studied in the context of the project 'The cultural landscape of the past 6000 years in Southern Sweden'. Pollen, plant macrofossils, diatoms, physical and chemical analysis, magnetic measurements and radiometric methods (Pb-210, C-14) have been used to study palaeoecological changes, i.e. climate, land use, lake trophy and soil erosion during the past 3000 years. This multidisciplinary study shows striking responses of diatom communities, physical and chemical characteristics, sediment yields and magnetic parameters to land-use changes and lake-level fluctuations. Moreover, the latter are closely related to the settlement history at the site, inferred from archaeological records and historical sources. Before 650 AD, the limnological development was affected mainly by lake-level fluctuations, but partly also by human impact (extensive forest clearings and dominant pastoral farming). With the expansion of arable farming (around 650 AD), human impact on the landscape was the major factor influencing soil erosion processes in the catchment and limnological changes in the lake.
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| 6. |
- Ion, John, et al.
(author)
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Diagrams for laser materials processing
- 1992
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In: Acta Metallurgica et Materialia. - 0956-7151. ; 40:7, s. 1539-1551
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Journal article (peer-reviewed)abstract
- An analytical heat flow model is used to identify dimensionless parameter groups which determine the temperature field produced in a material by a scanning laser beam. The groups are used to plot experimental data for metallic alloys on a processing diagram for a range of continuous CO2 laser treatments. Practical operating regions for each type of treatment are thus identified, which coincide with those predicted using the heat flow model. The model is extended in order to construct more detailed diagrams for transformation hardening, surface melting and keyhole welding, which quantify the depth of treatment. By using realistic estimates of certain poorly-known process variables, good agreement is observed between measured and predicted data. Methods for optimising processing parameters with respect to various criteria are presented for transformation hardening. The diagrams, which are constructed on a personal computer, are a useful tool for summarising current data, optimising practical processing parameters, and assessing the potential of novel laser treatments on new materials
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| 7. |
- Janssen, Wiel H., et al.
(author)
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Driver support
- 1993
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In: Generic intelligent driver support. - London : Taylor and Francis Group. - 0748400699 ; , s. 53-66
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Book chapter (other academic/artistic)
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| 8. |
- Nash, Gerard, et al.
(author)
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Haemorheological result in a large multicentre study of claudicants treated with ketanserin
- 1990
-
In: Clinical Hemorheology. - New York, USA : Pergamon Press. - 0271-5198. ; 10, s. 321-327
-
Journal article (peer-reviewed)abstract
- Abstract An international, multi-centre trial was carried out to test the haemorheological effects of ketanserin, a serotonin antagonist, after treatment of intermittent claudicants for 1 year. Haematological indices, whole blood viscosity, plasma viscosity and red cell and white cell filterabi1ity were measured using standardised techniques. Even so, inter-laboratory variability, and intra-laboratory changes in control values in some centres over the 1 year period proved to be major obstacles. The pooled data showed no evidence of haemorheological changes, although data from the single largest centre indicated slightly lowered haematocrit and blood and plasma viscosity. Any rheological effects of serotonin antagonists in intermittent claudicants are probably small and unlikely to be the main source of any clinical efficacy. In general, it would appear that standardisation and monitoring of laboratory techniques must be strictly carried out if there is to be any hope of successfully carrying out multi-centre haemorheological trials. . Key words: Blood Rheology; Claudication; Serotonin Antagonists;
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| 9. |
- Steenfos, H, et al.
(author)
-
Increased gene expression of scatter factor-hepatocyte growth factor and basic fibroblast growth factor in granulation tissue in the rat.
- 1993
-
In: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. - 1067-1927. ; 1:4, s. 231-5
-
Journal article (peer-reviewed)abstract
- Scatter factor-hepatocyte growth factor is a protein secreted by fibroblasts which disperses colonies of epithelial cells and keratinocytes in culture. The factor is also a patent mitogen for hepatocytes, synthesized in the liver. Basic fibroblast growth factor, another heparin-binding factor, is most abundant in the brain but also plays a role in wound healing. Using a solution hybridization/RNAase protection assay, we have measured the abundance of messenger RNA for scatter factor-hepatocyte growth factor and basic fibroblast growth factor in granulation tissue obtained from subcutaneously Hunt-Schilling wound cylinders. The levels of scatter factor-hepatocyte growth factor messenger RNA increased after weeks 2 through 4 to a twofold higher level in weeks 5 through 7 after implantation of the cylinders, whereas no changes in basic fibroblast growth factor messenger RNA levels were noticed. At week 3 after implantation of the cylinders, scatter factor-hepatocyte growth factor messenger RNA levels in granulation tissue were more than threefold higher than in skin dermis fibroblasts but markedly lower than in the liver. The abundance of basic fibroblast growth factor messenger RNA was also significantly increased in granulation tissue compared with dermis but, as expected, markedly lower than in the brain. In conclusion, the gene expression of the scatter factor-hepatocyte growth factor, as well as basic fibroblast growth factor, is increased in granulation tissue. Because there was a time-dependent increase in the expression of scatter factor-hepatocyte growth factor, it is hypothesized that scatter factor-hepatocyte growth factor acts as a signal from fully developed granulation tissue to stimulate skin epithelial cells to scatter over the wound.
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| 10. |
- Tarnow, Peter, 1963, et al.
(author)
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Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds.
- 1994
-
In: Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi. - 0284-4311. ; 28:4, s. 255-9
-
Journal article (peer-reviewed)abstract
- Application of zinc oxide has been shown to accelerate the healing of both chronic and acute wounds, but the mechanisms are unknown. We quantified the gene expression (mRNA) for one important growth factor, insulin-like growth factor-1 (IGF-1) in 12 full-thickness wounds in each of three domestic pigs treated with or without topical zinc oxide. We used a RNAase protection/solution hybridisation technique to measure IGF-1 mRNA concentrations, which were 50% higher in the granulation tissue in wounds treated with zinc oxide compared with control wounds on days 3-4 (p < 0.05), but not thereafter (up to postoperative day 11). Topical zinc oxide increased the healing rate of wounds compared to the control group (p < 0.01). The cell composition of the granulation tissue was similar in the two groups. The increased gene expression of IGF-1 may be one mechanism by which topical zinc oxide enhances wound healing.
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