| 1. |
- Binde, Per, 1956, et al.
(författare)
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Inledning: Spelberoendes riksförbund tio år
- 2010
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Ingår i: Spelberoendes riksförbund 10 år: En jubileumsskrift, red. P. Binde & J. Jonsson. - Östersund : Statens folkhälsoinstitut. - 9789172576858 ; , s. 6-11
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Den svenska spelmarknaden har förändrats och växt kraftigt den senaste tioårsperioden. Vi har fått statliga kasinon och på Internet går det att spela på det mesta från bingo till poker. Så gott som dagligen rapporterar massmedia om spelpolitik och spelberoende. Medvetenheten om spelberoende har ökat och starkt bidragande till det är Spelberoendes riksförbund. Förbundet har i tio år informerat om spelberoende och gett stöd till människor med spelproblem och deras anhöriga. Den här jubileumsskriften ger en bild av spelproblem i Sverige och kamratstödet i spelberoendes föreningar. Ungas spelande och de anhörigas situation tas upp av flera författare. Läsaren får också veta hur medvetenheten om spelberoende växte fram i Sverige och ta del av diskussioner om hur framtidens spelande kan gestalta sig. I boken medverkar aktiva inom förbundet, eldsjälar från lokalföreningar och spelberoende som har fått hjälp. Även spelforskare och personer som på olika sätt arbetat med spelfrågor har bidragit med kapitel. Skriften är utgiven med stöd av Statens folkhälsoinstitut. I detta inledningskapitel presenteras spelberoendes riksförbund, författarna och deras bidrag till jubileumsskriften.
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| 2. |
- Carlbring, Per, 1972-, et al.
(författare)
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Internet-based treatment of pathological gambling with a three-year follow-up
- 2012
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Ingår i: Cognitive Behaviour Therapy. - : Routledge. - 1650-6073 .- 1651-2316. ; 41:4, s. 321-34
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Tidskriftsartikel (refereegranskat)abstract
- Effective therapies for pathological gambling exist, but their use is limited to about 10% of the target population. In an attempt to lower the barriers for help, Internet-based cognitive behavioural therapy (ICBT) has been shown to be effective when delivered to a non-depressed sample with pathological gambling. This study sought to extend this finding to a larger, more representative population, and also test a model to predict responder status. Following advertisement, a total of 284 participants started an 8-week ICBT programme with minimal therapist contact via e-mail and weekly telephone calls of less than 15 min. The average time spent on each participant, including telephone conversations, e-mail, and administration, was 4 h. In addition to a mixed effects model to evaluate the effectiveness of the treatment, two logistic regression analyses were performed with the following eight pre-defined response predictor variables: work-life satisfaction, primary gambling activity, debts due to gambling, social support, personal yearly salary, alcohol consumption, stage of change, and dissociative gambling. ICBT resulted in statistically significant reductions in the scores of pathological gambling, anxiety, and depression as well as an increase in quality of life compared to pre-treatment levels. Follow-ups carried out in the treatment group at 6, 18, and 36 months indicated that treatment effects were sustained. Using the eight predictor variable model rendered an acceptable predictive ability to identify responders both at post-test (AUC = .72, p < .01) and at 36-month follow-up (AUC = .70, p < .01). We conclude that ICBT for pathological gamblers, even if depressed, can be effective and that outcome can partly be predicted by pre-treatment characteristics.
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| 3. |
- Carlbring, Per, et al.
(författare)
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Spelberoende
- 2013. - 2
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Ingår i: KBT inom psykiatrin. - Stockholm : Natur och kultur. - 9789127135604 ; , s. 337-353
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Här beskrivs hur KBT kan tillämpas vid de vanligaste psykiatriska tillstånden. I denna uppdaterade och utvidgade utgåva har nya kapitel tillkommit, bland annat om fallformulering, spelberoende, internetbehandling samt KBT och psykofarmaka. (Från baksidestexten.)
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| 4. |
- Conley, Daniel, et al.
(författare)
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Hypoxia is increasing in the coastal zone of the Baltic Sea
- 2011
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 45:16, s. 6777-6783
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Tidskriftsartikel (refereegranskat)abstract
- Hypoxia is a well-described phenomenon in the offshore waters of the Baltic Sea with both the spatial extent and intensity of hypoxia known to have increased due to anthropogenic eutrophication, however, an unknown amount of hypoxia is present in the coastal zone. Here we report on the widespread unprecedented occurrence of hypoxia across the coastal zone of the Baltic Sea. We have identified 115 sites that have experienced hypoxia during the period 1955-2009 increasing the global total to ca. 500 sites, with the Baltic Sea coastal zone containing over 20% of all known sites worldwide. Most sites experienced episodic hypoxia, which is a precursor to development of seasonal hypoxia. The Baltic Sea coastal zone displays an alarming trend with hypoxia steadily increasing with time since the 1950s effecting nutrient biogeochemical processes, ecosystem services, and coastal habitat.
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| 5. |
- Elebro, Jacob, et al.
(författare)
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Prognostic and treatment predictive significance of SATB1 and SATB2 expression in pancreatic and periampullary adenocarcinoma
- 2014
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Ingår i: Journal of Translational Medicine. - : Springer Science and Business Media LLC. - 1479-5876. ; 12, s. 289-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas generally have a better prognosis, but little is known on optimal neoadjuvant and adjuvant treatment. New prognostic and treatment predictive biomarkers are needed for improved treatment stratification of patients with both types of periampullary adenocarcinoma. Expression of the Special AT-rich sequence-binding protein 1 (SATB1) has been demonstrated to confer a worse prognosis in several tumour types, whereas its close homologue SATB2 is a proposed diagnostic and favourable prognostic marker for colorectal cancer. The prognostic value of SATB1 and SATB2 expression in periampullary adenocarcinoma has not yet been described. Methods: Immunohistochemical expression of SATB1 and SATB2 was analysed in tissue microarrays with primary tumours and a subset of paired lymph node metastases from 175 patients operated with pancreaticoduodenectomy for periampullary adenocarcinoma. Kaplan-Meier and Cox regression analysis were applied to explore the impact of SATB1 and SATB2 expression on recurrence free survival (RFS) and overall survival (OS). Results: Positive expression of SATB1 was denoted in 16/106 primary pancreatobiliary type tumours and 11/65 metastases, and in 15/63 primary intestinal type tumours and 4/26 metastases, respectively. Expression of SATB1 was an independent predictor of a significantly shorter RFS and OS in pancreatobiliary type, but not in intestinal type adenocarcinomas. Moreover, SATB1 expression predicted an improved response to adjuvant chemotherapy in both tumour types. SATB2-expression was seen in 3/107 pancreatobiliary type primary tumours, and in 8/61 intestinal type primary tumours. The small number of cases with positive SATB2 expression did not allow for any firm conclusions on its prognostic value. Conclusions: These findings demonstrate the potential utility of SATB1 as a prognostic and predictive biomarker for chemotherapy response in both intestinal type and pancreatobiliary type periampullary adenocarcinomas, including pancreatic cancer.
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| 6. |
- Fernaeus, Ylva, et al.
(författare)
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Revisiting the jacquard loom : threads of history and current patterns in HCI
- 2012
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Ingår i: CHI '12 Proceedings of the SIGCHI Conference on Human Factors in Computing Systems. - New York : Association for Computing Machinery (ACM). - 9781450310154 ; , s. 1593-1602
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Konferensbidrag (refereegranskat)abstract
- In the recent developments of human computer interaction, one central challenge has been to find and to explore alternatives to the legacy of the desktop computer paradigm for interaction design. To investigate this issue further we have conducted an analysis on a fascinating piece of machinery often referred to as one of the predecessors of the modern day computer, the Jacquard loom. In analysing the Jacquard loom we look at qualities in design and interaction from some different perspectives: how historical tools, crafts, and practices can inform interaction design, the role of physicality, materiality, and full-body interaction in order to rethink some current conceptions of interaction and design of computational devices.
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| 7. |
- Fristedt, Richard, et al.
(författare)
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Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis
- 2014
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:11, s. 112728-112728
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Tidskriftsartikel (refereegranskat)abstract
- The polymeric immunoglobulin receptor (pIgR) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High pIgR expression has been reported to correlate with a less aggressive tumour phenotype and an improved prognosis in several human cancer types. Here, we examined the expression and prognostic significance of pIgR in pancreatic and periampullary adenocarcinoma. The study cohort encompasses a consecutive series of 175 patients surgically treated with pancreaticoduodenectomy for pancreatic and periampullary adenocarcinoma in Malmö and Lund University Hospitals, Sweden, between 2001-2011. Tissue microarrays were constructed from primary tumours (n = 175) and paired lymph node metastases (n = 105). A multiplied score was calculated from the fraction and intensity of pIgR staining. Classification and regression tree analysis was used to select the prognostic cut-off. Unadjusted and adjusted hazard ratios (HR) for death and recurrence within 5 years were calculated. pIgR expression could be evaluated in 172/175 (98.3%) primary tumours and in 96/105 (91.4%) lymph node metastases. pIgR expression was significantly down-regulated in lymph node metastases as compared with primary tumours (p = 0.018). Low pIgR expression was significantly associated with poor differentiation grade (p < 0.001), perineural growth (p = 0.027), lymphatic invasion (p = 0.016), vascular invasion (p = 0.033) and infiltration of the peripancreatic fat (p = 0.039). In the entire cohort, low pIgR expression was significantly associated with an impaired 5-year survival (HR = 2.99, 95% confidence interval (CI) 1.71-5.25) and early recurrence (HR = 2.89, 95% CI 1.67-4.98). This association remained significant for survival after adjustment for conventional clinicopathological factors, tumour origin and adjuvant treatment (HR = 1.98, 95% CI 1.10-3.57). These results demonstrate, for the first time, that high tumour-specific pIgR expression signifies a more favourable tumour phenotype and that low expression independently predicts a shorter survival in patients with pancreatic and periampullary cancer. The mechanistic basis for the putative tumour suppressing properties of pIgR in these cancers merits further study.
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| 8. |
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| 9. |
- Hultman, Axel, 1975-, et al.
(författare)
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The topology of the space of matrices of Barvinok rank two
- 2010
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Ingår i: Beiträge zur Algebra und Geometrie. - Lemgo, Germany : Heldermann Verlag. - 0138-4821. ; 51:2, s. 373-390
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Tidskriftsartikel (refereegranskat)abstract
- The Barvinok rank of a d x n matrix is the minimum number of points in Rd such that the tropical convex hull of the points contains all columns of the matrix. The concept originated in work by Barvinok and others on the travelling salesman problem. Our object of study is the space of real d x n matrices of Barvinok rank two. Let Bd,n denote this space modulo rescaling and translation. We show that Bd,n is a manifold, thereby settling a conjecture due to Develin. In fact, Bd,n is homeomorphic to the quotient of the product of spheres Sd-2 x Sn-2 under the involution which sends each point to its antipode simultaneously in both components. In addition, using discrete Morse theory, we compute the integral homology of Bd,n. Assuming d \ge n, for odd d the homology turns out to be isomorphic to that of Sd-2 x RPn-2. This is true also for even d up to degree d-3, but the two cases differ from degree d-2 and up. The homology computation straightforwardly extends to more general complexes of the form (Sd-2 x X)//Z2, where X is a finite cell complex of dimension at most d-2 admitting a free Z2-action.
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