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Träfflista för sökning "WFRF:(Jung Jae U) srt2:(2015-2019)"

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1.	Klionsky, Daniel J, et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 12:1, s. 1-222 Journal article (peer-reviewed)
2.	Lee, Jun Han, et al. (author) TPL2 is an oncogenic driver in keratocanthoma and squamous cell carcinoma 2016 In: Cancer Research. - 0008-5472. ; 76:22, s. 6712-6722 Journal article (peer-reviewed)abstract Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA. Here, we show that TPL2 over-expression induced both cell transformation in immortalized human keratinocytes and SCC and KA-like cutaneous SCC (cSCC) development in mice. Mechanistically, activation of TPL2 downstream signaling pathways such as MEK/ERK MAPK, mTOR, NF-κB, and p38 MAPK leads to TPL2-mediated cell transformation in immortalized human keratinocytes and tumorigenesis in mice. Most importantly, TPL2 overexpression is required for iTPL2 TG-driven SCC and KA-like cSCC tumor maintenance, validating TPL2 as a possible drug target for the treatment of SCC/KA. Finally, we verified that TPL2 is over-expressed in human cutaneous metastatic SCC and KA clinical specimens compared with normal skin. Taken together, our results establish TPL2 as an oncogenic driver in SCC/KA development.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Zhang, Yan (1); Korhonen, Laura (1); Lindholm, Dan (1); Vertessy, Beata G. (1); Wang, Mei (1); Wang, Xin (1); show more...; Liu, Yang (1); Kumar, Rakesh (1); Wang, Dong (1); Li, Ke (1); Liu, Ke (1); Zhang, Yang (1); Nàgy, Péter (1); Kominami, Eiki (1); van der Goot, F. Gis ... (1); Bonaldo, Paolo (1); Thum, Thomas (1); Adams, Christopher M (1); Minucci, Saverio (1); Vellenga, Edo (1); Swärd, Karl (1); Nilsson, Per (1); Forslund, Ola (1); De Milito, Angelo (1); Zhang, Jian (1); Shukla, Deepak (1); Kågedal, Katarina (1); Chen, Guoqiang (1); Liu, Wei (1); Cheetham, Michael E. (1); Sigurdson, Christina ... (1); Clarke, Robert (1); Zhang, Fan (1); Gonzalez-Alegre, Ped ... (1); Jin, Lei (1); Chen, Qi (1); Taylor, Mark J. (1); Romani, Luigina (1); Wang, Ying (1); Kumar, Ashok (1); Simons, Matias (1); Ishaq, Mohammad (1); Yang, Qian (1); Laukkarinen, Johanna (1); Algül, Hana (1); Brest, Patrick (1); Simon, Hans-Uwe (1); Mograbi, Baharia (1); Florey, Oliver (1); Ström, Anna-Lena (1); show less...

University: Lund University (2); Umeå University (1); Stockholm University (1); Linköping University (1); Karolinska Institutet (1); Swedish University of Agricultural Sciences (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

Year: 2016 (2)

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