| 1. |
- Dhar, S., et al.
(author)
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Multi-axial Fatigue of Head-Hardened Pearlitic and Austenitic Manganese Railway Steels: A Comparative Study
- 2020
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In: Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science. - : Springer Science and Business Media LLC. - 1073-5623. ; 51:11, s. 5639-5652
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Journal article (peer-reviewed)abstract
- Switches and crossings (S&Cs) in rail networks suffer from damage and deformation due to severe loading of their complex geometric shapes. This article presents a comparative study of the cyclic deformation characteristics and fatigue behavior of two typical crossing materials, namely head-hardened pearlitic steel and Hadfield manganese steel, as well as the associated microstructural changes. Both uniaxial and biaxial loadings (proportional and non-proportional) are studied. The pearlitic steel endured more cycles to failure for a given strain amplitude compared to the manganese steel. The cyclic response of manganese steel shows significant hardening whereas softening was observed for the pearlitic steel except under biaxial non-proportional loading. The microstructures developed in the two types of steels after deformation are characterized by optical (OM) and transmission electron microscopy (TEM). TEM micrographs reveal that the deformed microstructure of the pearlitic steel consists of threading dislocations and dislocation tangles in the ferrite lamellae. The microstructures in the manganese steel after the different loadings are composed of dislocation cells with dislocation tangles inside, intersected by straight stacking fault lamellae. The observed microstructures are related to the results of the mechanical test, and the suitability of the steels for use in S&Cs is discussed.
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| 2. |
- Hansen, A. B., et al.
(author)
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DIAGNOSIS OF ENDOCRINE DISEASE : Sex steroid action in adolescence: too much, too little; too early, too late
- 2021
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In: European Journal of Endocrinology. - 1479-683X. ; 184:1, s. 17-28
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Research review (peer-reviewed)abstract
- Abstract: This review aims to cover the subject of sex steroid action in adolescence. It will include situations with too little sex steroid action, as seen in for example, Turners syndrome and androgen insensitivity issues, too much sex steroid action as seen in adolescent PCOS, CAH and gynecomastia, too late sex steroid action as seen in constitutional delay of growth and puberty and too early sex steroid action as seen in precocious puberty. This review will cover the etiology, the signs and symptoms which the clinician should be attentive to, important differential diagnoses to know and be able to distinguish, long-term health and social consequences of these hormonal disorders and the course of action with regards to medical treatment in the pediatric endocrinological department and for the general practitioner. This review also covers situations with exogenous sex steroid application for therapeutic purposes in the adolescent and young adult. This includes gender-affirming therapy in the transgender child and hormone treatment of tall statured children. It gives some background information of the cause of treatment, the patient's motivation for medicating (or self-medicating), long-term consequences of exogenous sex steroid treatment and clinical outcome of this treatment.
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| 3. |
- Nielsen, Morten Aagaard, et al.
(author)
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Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB
- 2022
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 13
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Journal article (peer-reviewed)abstract
- 4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin-3 (Gal-3) decreases the cellular response to its ligand (4-1BBL). Gal-3 binds to both soluble 4-1BB (s4-1BB) and membrane-bound 4-1BB (mem4-1BB), without blocking co-binding of 4-1BBL. In plasma, we detected complexes composed of 4-1BB and Gal-3 larger than 100 nm in size; these complexes were reduced in synovial fluid from rheumatoid arthritis. Both activated 4-1BB+ T cells and 4-1BB-transfected HEK293 cells depleted these complexes from plasma, followed by increased expression of 4-1BB and Gal-3 on the cell surface. The increase was accompanied by a 4-fold decrease in TNFα production by the 4-1BBhighGal-3+ T cells, after exposure to 4-1BB/Gal-3 complexes. In RA patients, complexes containing 4-1BB/Gal-3 were dramatically reduced in both plasma and SF compared with healthy plasma. These results support that Gal-3 binds to 4-1BB without blocking the co-binding of 4-1BBL. Instead, Gal-3 leads to formation of large soluble 4-1BB/Gal-3 complexes that attach to mem4-1BB on the cell surfaces, resulting in suppression of 4-1BBL’s bioactivity.
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