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Search: WFRF:(Kansy Manfred) > (2015)

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  • Matsson, Pär, et al. (author)
  • Quantifying the impact of transporters on cellular drug permeability.
  • 2015
  • In: TIPS - Trends in Pharmacological Sciences. - : Elsevier BV. - 0165-6147 .- 1873-3735. ; 35:5, s. 255-262
  • Journal article (peer-reviewed)abstract
    • The conventional model of drug permeability has recently been challenged. An alternative model proposes that transporter-mediated flux is the sole mechanism of cellular drug permeation, instead of existing in parallel with passive transmembrane diffusion. We examined a central assumption of this alternative hypothesis; namely, that transporters can give rise to experimental observations that would typically be explained with passive transmembrane diffusion. Using systems-biology simulations based on available transporter kinetics and proteomic expression data, we found that such observations are possible in the absence of transmembrane diffusion, but only under very specific conditions that rarely or never occur for known human drug transporters.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Artursson, Per (2)
Matsson, Pär (2)
Lundquist, Patrik (2)
Kansy, Manfred (2)
Wisniewski, Jacek R. (2)
Fenu, Luca A. (2)
University
Uppsala University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
2015 (2)Undo refine

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