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Träfflista för sökning "WFRF:(Karlsson B) srt2:(1990-1999)"

Search: WFRF:(Karlsson B) > (1990-1999)

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  • Lanne, B, et al. (author)
  • Glycoconjugate receptors for P-fimbriated Escherichia coli in the mouse. An animal model of urinary tract infection.
  • 1995
  • In: The Journal of biological chemistry. - 0021-9258. ; 270:15, s. 9017-25
  • Journal article (peer-reviewed)abstract
    • Glycosphingolipids were isolated from kidneys, urethers, and bladders (including urethrae) of C3H/HeN mice. Binding was studied of a clinical isolate and recombinant strains of uropathogenic P-fimbriated Escherichia coli to these glycolipids. A series of receptor-active glycolipids with Gal alpha 4Gal in common, previously shown to be recognized by these bacteria, was identified by use of specific monoclonal antibodies, fast-atom bombardment and electron-impact mass spectrometry, and proton nuclear magnetic resonance spectroscopy: galabiosylceramide (Gal alpha 4Gal beta Cer), globotriaosylceramide (Gal alpha 4Gal beta 4Glc beta Cer), globoside (GalNAc beta 3Gal alpha 4Gal beta 4Glc beta Cer), the Forssman glycolipid (GalNAc alpha 3GalNAc beta 3Gal alpha 4Gal beta 4Glc beta Cer), Gal beta 4GlcNAc beta 6(Gal beta 3)GalNAc beta 3Gal alpha 4Gal beta 4Glc beta Cer, and Gal beta 4(Fuc alpha 3)GlcNAc beta 6(Gal beta 3)GalNAc beta 3Gal alpha 4Gal beta 4Glc beta Cer. The binding pattern for mouse kidney glycolipids differed from that for kidney glycolipids of man and monkey. In particular, the dominant 8-sugar glycolipid in the mouse was not detected in the primates. A second difference was found in the binding of E. coli to kidney glycoproteins on blots after electrophoresis; the mouse showed distinct receptor-active bands while human and monkey did not. These differences may be of relevance when using the mouse as a model for clinical urinary tract infection of man.
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  • Hellquist, H. B., et al. (author)
  • Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12
  • 1996
  • In: Virchows Archiv. - New York, USA : Springer. - 0945-6317 .- 1432-2307. ; 429:2-3, s. 149-158
  • Journal article (peer-reviewed)abstract
    • Certain cytokines are involved in the generation of natural killer (NK) cells and participate in the regulation of the proto-oncogene bcl-2. We aimed to study the mRNA expression of interleukin (IL)-2, IL-4 and IL-5, the composition of the tumour infiltrating lymphocytes (TIL), and the expression of bcl-2 in 14 benign and malignant human parotid tumours. T IL were predominantly composed of T lymphocytes and NK cells. We found evidence for the homing of T cells, and for generation of NK cells in the vicinity of the tumours. mRNA for IL-2 and IL-12, were identified but IL-4 mRNA was not found. The cytokine profiles and the composition of TIL of the two tumour categories were indistinguishable, suggesting that these host-response variables do not explain the differences in biological behaviour of these particular tumours. The results support a shift towards Th 1 (T helper 1) cells and interferon-gamma production, and that IL-12 also in vivo may play an important role in the regulatory interaction between innate resistance and adaptive immunity in tumour diseases. Most infiltrating lymphocytes showed strong expression of bcl-2; an interesting observation with regard to lymphocytic apoptosis in neoplastic diseases. The immunoreactivity for the bcl-2 protein varied considerably between and within tumours, and almost all benign tumours showed strong bcl-2 positively whereas several of the malignant tumours showed weak or absent staining. The variable expression of bcl-2 protein suggests a different susceptibility of tumour cells to apoptosis. The results also indicate that bcl-2 cannot pla a major role as protective agent in the specific apoptotic pathway induced by NK cells.
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  • Result 1-10 of 262
Type of publication
journal article (227)
conference paper (20)
reports (4)
other publication (4)
doctoral thesis (3)
book chapter (2)
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editorial collection (1)
review (1)
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Type of content
peer-reviewed (202)
other academic/artistic (60)
Author/Editor
Karlsson, B (39)
Karlsson, L (20)
Wannberg, B (20)
Baltzer, P (15)
Karlsson, E (14)
HOLLAND, DMP (14)
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Karlsson, Mats G, 19 ... (13)
Karlsson, Ulf O. (12)
MACDONALD, MA (12)
Karlsson-Parra, A (11)
Karlsson, A. (10)
Winblad, B (9)
Karlsson, T (9)
Lundqvist, M (9)
Karlsson, P (9)
Karlsson, S. (9)
Hayes, MA (9)
Karlsson, FA (9)
Lindquist, C (8)
Karlsson, G (8)
Rönnelid, Mats (8)
Roos, A. (8)
Nostell, P (8)
Kanski, J (7)
Hakansson, M C (7)
Kihlstrom, L (7)
Wimo, A (7)
Davidsson, Åke, 1956 ... (7)
Herlitz, Johan (6)
Sundberg, B. (6)
Wallentin, L (6)
Ilver, L (6)
Karlsson, J. (6)
Nilsson, B (6)
Korsgren, O (6)
Andersson, C B M (6)
Olsson, L O (6)
Hjorvarsson, B (6)
Hartford, M (6)
Zhu, S. (5)
Halldin, C (5)
Karlsson, K (5)
Fagerlund, M (5)
Farde, L (5)
Wennberg, L (5)
SWAHN, CG (5)
Gebre-Medhin, M (5)
GROTH, CG (5)
Bergström, Jörgen, 1 ... (5)
Karlsson, Karl-Ander ... (5)
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University
Uppsala University (86)
Karolinska Institutet (66)
University of Gothenburg (22)
Royal Institute of Technology (18)
Lund University (17)
Örebro University (14)
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Linköping University (8)
University of Borås (8)
Högskolan Dalarna (8)
Umeå University (5)
Jönköping University (5)
University of Skövde (5)
Chalmers University of Technology (5)
Luleå University of Technology (4)
Linnaeus University (3)
University of Gävle (2)
Kristianstad University College (1)
Stockholm University (1)
Mälardalen University (1)
Karlstad University (1)
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Language
English (256)
Swedish (5)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (51)
Natural sciences (15)
Engineering and Technology (12)
Social Sciences (1)

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