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1.	Bouyoucef, S E, et al. (author) Poster Session 2 : Monday 4 May 2015, 08 2015 In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1 Journal article (peer-reviewed)
2.	Semba, H, et al. (author) HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity 2016 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 11635- Journal article (peer-reviewed)abstract In severely hypoxic condition, HIF-1α-mediated induction of Pdk1 was found to regulate glucose oxidation by preventing the entry of pyruvate into the tricarboxylic cycle. Monocyte-derived macrophages, however, encounter a gradual decrease in oxygen availability during its migration process in inflammatory areas. Here we show that HIF-1α-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting a mode of glycolytic reprogramming. In primary macrophages, PKM2, a glycolytic enzyme responsible for glycolytic ATP synthesis localizes in filopodia and lammelipodia, where ATP is rapidly consumed during actin remodelling processes. Remarkably, inhibition of glycolytic reprogramming with dichloroacetate significantly impairs macrophage migration in vitro and in vivo. Furthermore, inhibition of the macrophage HIF-1α-PDK1 axis suppresses systemic inflammation, suggesting a potential therapeutic approach for regulating inflammatory processes. Our findings thus demonstrate that adaptive responses in glucose metabolism contribute to macrophage migratory activity.
3.	Toki, T, et al. (author) De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome 2018 In: American journal of human genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 103:3, s. 440-447 Journal article (peer-reviewed)

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Costa, G. (1); Nagai, R. (1); Wang, R. (1); Yamaguchi, Y. (1); Robinson, J. (1); Santos, J. (1); show more...; Smith, M. (1); Brünner, S. (1); Robinson, S. (1); Sakaguchi, H. (1); Li, Q. (1); Soerensen, J. (1); Antoni, Gunnar (1); Sörensen, Jens (1); Reid, S. (1); Svensson, M. (1); Menendez, D. (1); Takahashi, K (1); Yousefi, B (1); Mizuno, S. (1); Wikstrom, G. (1); Soares, J (1); Bottcher, M. (1); Abe, H. (1); Fernandez, J. (1); Miura, M. (1); Nakajima, Y. (1); Tanaka, H. (1); Takahashi, S. (1); Yla-Herttuala, S (1); Miyano, S (1); Torres, M. (1); Martinez, C (1); Ferrari, C. (1); Reddy, P (1); Ramos, D (1); Sato, T (1); Lehner, S. (1); Ogawa, S. (1); Cheng, B (1); Johnson, L (1); Sanada, M (1); Akil, S (1); Hedeer, F (1); Engblom, H (1); Hindorf, C (1); Yoshida, K. (1); Sayed, S (1); Kataoka, K (1); Sato, Y (1); show less...

University: Karolinska Institutet (2); Uppsala University (1)

Language: English (3)

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