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Träfflista för sökning "WFRF:(Keene Alex C) srt2:(2010-2014)"

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1.	Meskhidze, Nicholas, et al. (author) Production mechanisms, number concentration, size distribution, chemical composition, and optical properties of sea spray aerosols 2013 In: Atmospheric Science Letters. - : Wiley. - 1530-261X. ; 14:4, s. 207-213 Journal article (peer-reviewed)
2.	Neely, G Gregory, et al. (author) A Genome-wide Drosophila Screen for Heat Nociception Identifies alpha 2 delta 3 as an Evolutionarily Conserved Pain Gene 2010 In: Cell. - : Elsevier Science B.V., Amsterdam.. - 0092-8674 .- 1097-4172. ; 143:4, s. 628-638 Journal article (peer-reviewed)abstract Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the alpha 2 delta family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (alpha 2 delta 3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, alpha 2 delta 3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in alpha 2 delta 3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in alpha 2 delta 3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Johnson, Matthew S (1); Ceburnis, Darius (1); Alenius, Mattias (1); Worsnop, Douglas R. (1); Penninger, Josef M. (1); de Leeuw, Gerrit (1); show more...; Salter, Matthew (1); Diatchenko, Luda (1); Belfer, Inna (1); Petters, Markus D. (1); Smirnov, Alexander (1); Russell, Lynn M. (1); Rinaldi, Matteo (1); DeMott, Paul J. (1); Facchini, Maria Cris ... (1); Tsigaridis, Kostas (1); Bellen, Hugo J. (1); Pospisilik, J. Andre ... (1); O'Dowd, Colin (1); Prather, Kimberly A. (1); Hu, Yongxiang (1); Meskhidze, Nicholas (1); Bates, Tim (1); Reid, Jeff (1); Lewis, Ernie R. (1); Gantt, Brett (1); Anguelova, Magdalena ... (1); Bhave, Prakash V. (1); Bird, James (1); Callaghan, Adrian H. (1); Chang, Rachel (1); Clarke, Antony (1); Deane, Grant (1); Elliot, Scott (1); Fairall, Chris W. (1); Hawkins, Lelia (1); Hudson, James G. (1); Kaku, Kathleen C. (1); Keene, William C. (1); Kieber, David J. (1); Long, Michael S. (1); Martensson, Monica (1); Modini, Rob L. (1); Osburn, Chris L. (1); Pszenny, Alex (1); Sayer, Andrew M. (1); Suda, Sarah R. (1); Toth, Travis D. (1); Wozniak, Andrew (1); Zorn, Sören R. (1); show less...

University: Umeå University (1); Uppsala University (1); Stockholm University (1); Linköping University (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1)

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