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- Kempi, V., et al.
(author)
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Evaluation of renal function parameters with simultaneously administered 99mTc-DTPA and 131I-hippuran
- 1983
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In: European Journal Of Nuclear Medicine. - 0340-6997. ; 8:2, s. 65-71
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Journal article (peer-reviewed)abstract
- The present study aimed at comparing two renal function tests using 99mTc-DTPA (diethylene triamine penta acetic acid) and 131I-labeled hippuran (o-hippuric acid). A mixture of 80 Mbq 99mTc-DTPA and 7.4 MBq 131I-hippuran in a total volume of 1.5 ml or less was injected into an arm-vein. Both radiopharmaceuticals have identical intitial distributions in the blood pool when injected in this manner. Seventy-two patients were studied with the present dual radionuclide technique. The following parameters were derived from the renogram: area under curve, uptake ratio, Tmax, decrease ratio, excretion ratio, and rate of decrease. The parameters for 99mTc-DTPA and 131I-hippuran were compared for various kidney groups. Generally the renographic parameters were well correlated. Apart from the systematic differences due to different modes of renal excretion, the curve patterns virtually agreed. The differences that were observed between the two tracers lacked clinical significance.
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| 2. |
- Persson, B. R.R., et al.
(author)
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Labeling and testing of (99m)Tc streptokinase for the diagnosis of deep vein thrombosis
- 1975
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In: Journal of Nuclear Medicine. - 0161-5505. ; 16:6, s. 474-477
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Journal article (peer-reviewed)abstract
- A detailed study has been made of the method for labeling streptokinase with 99Tc(m) in order to get a radioactive indicator for rapid scintigraphic visualization of thrombi and emboli. The best method found for preparing 99Tc(m) streptokinase was by reducing 99Tc(m) pertechnetate with 2 μmole SnCl2 at pH 0.7 and then adding 50,000 to 75,000 IU of streptokinase at a final pH of about 2. After 1 hr of equilibration, the labeling efficiency was 75 to 80% as determined by the method of gel chromatography column scanning. The dynamic behavior and distribution of 99Tc(m) streptokinase in different organs was studied in rabbits where a high uptake was found in liver. In a clinical investigation using 99Tc(m) streptokinase prepared according to this work, however, the liver uptake in man was only 10 to 20%.
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