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Träfflista för sökning "WFRF:(Kieseier B) srt2:(2010-2014)"

Search: WFRF:(Kieseier B) > (2010-2014)

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1.	Link, J, et al. (author) Development of Antidrug Antibodies in Multiple Sclerosis Cohorts in Europe - Overview of Interferon Beta and Natalizumab Cases Tested for ADA in Different Countries 2014 In: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. - 0300-9475. ; 79:6, s. 475-475 Conference paper (other academic/artistic)
2.	Sominanda, A, et al. (author) Inhibition of endogenous interferon beta by neutralizing antibodies against recombinant interferon beta 2010 In: Archives of neurology. - : American Medical Association (AMA). - 1538-3687 .- 0003-9942. ; 67:9, s. 1095-1101 Journal article (peer-reviewed)
3.	Warnke, C., et al. (author) Changes to anti-JCV antibody levels in a Swedish national MS cohort 2013 In: Journal of Neurology Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 84:11, s. 1199-1205 Journal article (peer-reviewed)abstract Background The anti-JC virus (JCV) antibody status has been introduced to stratify patients with multiple sclerosis (MS) for higher or lower risk of progressive multifocal leukoencephalopathy (PML). Objective To assess the potential utility of anti-JCV antibody levels for earlier diagnosis or prediction of PML. Methods An analytically validated antibody assay was used to determine serological status, normalised optical density values, and dilution titres for anti-JCV antibodies. The method was applied to stored sera of 1157 patients with MS including five cases of PML, all enrolled in the Swedish pharmacovigilance study for natalizumab (NAT). Anticytomegalovirus (CMV) and antivaricella-zoster (VZV) antibody levels served as controls. Results Prior to treatment with NAT, anti-JCV antibody levels were stable in the anti-JCV positive patients. During therapy, a slight decrease in anti-JCV and anti-VZV antibody levels, but not anti-CMV antibody levels, was observed. All five patients who developed PML showed a mild to moderate increase in anti-JCV antibody levels at time of PML diagnosis; pre-PML samples suggested that this increase might start already prior to diagnosis of PML. Conclusions Treatment initiation with NAT may lead to a slight decrease in anti-JCV and anti-VZV antibody levels, suggestive of a mild suppressive effect of NAT on antibody levels. Our findings in five cases of PML demonstrate that the onset of PML can be accompanied by increasing anti-JCV antibodies in serum. Monitoring of anti-JCV antibody levels could potentially be used as a tool for prediction or earlier diagnosis of PML during NAT treatment for MS. Further studies are warranted.
4.	Warnke, C., et al. (author) The CSF JCV antibody index for diagnosis of natalizumab-associated PML 2014 In: European Journal of Neurology. - 1351-5101 .- 1468-1331. ; 261, s. S44-S45 Journal article (other academic/artistic)

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Type of publication: journal article (3); conference paper (1)

Type of content: other academic/artistic (2); peer-reviewed (2)

Author/Editor: Warnke, C (3); Fogdell-Hahn, A (3); Hillert, J (2); Olsson, T (2); Ramanujam, R (2); Kieseier, B. C. (2); show more...; Bergström, Tomas, 19 ... (1); Kockum, I. (1); Weber, T. (1); Maeurer, M (1); Jensen, PEH (1); Hemmer, B (1); Sievers, C (1); Deisenhammer, F (1); Donnes, P (1); Gold, R. (1); Link, J (1); Auer, M (1); Rahbar, A (1); Wattjes, M. P. (1); Kleinschnitz, C (1); Menge, T. (1); Davidson, J (1); Lawton, A (1); Hartung, HP (1); Hoepner, R (1); Stangel, M (1); Pawlita, M (1); Hohlfeld, R (1); Limmroth, V (1); Dehmel, T (1); Wolffram, K (1); Kieseier, BC (1); Lindberg, R (1); Plavina, T (1); Soerensen, PS (1); Lundkvist, M (1); Sominanda, A (1); Adams, O (1); Holmen, C (1); Goelz, S (1); Kieseier, B (1); Hartung, H. P. (1); Subramanyam, M (1); Kuempfel, T (1); Major, E (1); von Geldern, G. (1); Markwerth, P. (1); Wegner, F. (1); Straeten, V. (1); show less...

University: Karolinska Institutet (4); University of Gothenburg (1); Umeå University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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