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Träfflista för sökning "WFRF:(Knecht Wolfgang) srt2:(2008-2009)"

Search: WFRF:(Knecht Wolfgang) > (2008-2009)

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1.
  • Clausen, Anders Ranegaard, et al. (author)
  • A multisubstrate deoxyribonucleoside kinase from plants.
  • 2008
  • In: Nucleic acids symposium series. - : Oxford University Press (OUP). - 0261-3166 .- 1746-8272. ; :52, s. 489-490
  • Journal article (peer-reviewed)abstract
    • Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
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2.
  • Knecht, Wolfgang, et al. (author)
  • Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine
  • 2009
  • In: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 382:2, s. 430-433
  • Journal article (peer-reviewed)abstract
    • Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK) can additionally sensitize human cancer cell lines towards the anti-cancer drug gemcitabine. We show that this property is based on the Dm-dNK ability to efficiently phosphorylate gemcitabine. The 2.2 angstrom resolution structure of DmdNK in complex with gemcitabine shows that the residues Tyr70 and Arg105 play a crucial role in the firm positioning of gemcitabine by extra interactions made by the fluoride atoms. This explains why gemcitabine is a good substrate for Dm-dNK(. (C) 2009 Elsevier Inc. All rights reserved.
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