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- Afshari, Alireza, 1956, et al.
(author)
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Impact of Ventilation Rate, Ozone and Limonene on Perceived Air Quality in Offices
- 2002
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In: Proceedings of the Indoor Air 2002 Conference.
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Conference paper (peer-reviewed)abstract
- The objective of this study has been to clarify to what extent ozone (03) and 03 !limonene in interaction with surface materials has an impact on the indoor air quality in typical low-polluting offices at various, realistic air change rates. Changes of environmental conditions were performed seven days before the chemical sampling. Organic compounds were collected on Tenax TA adsorbent tubes and the samples were analysed by gas chromatography with flame ionisation and mass selective detectors. The concentration of Total Volatile Organic Compounds were asexpected found to be inversely proportional to air change rates. Aldehydes and organic acids werefound at increased levels when the air change rate was decreased from 1.0 h1 to 0.3 h1. Increased ventilation rate to 3.0 h1 did not induce additional changes in the chemical composition of aldehydes and organic acids. The fractions of aldehydes and organic acids relative to nonreactive alkanes indicated that chemical transformation in the indoor environment indeed took place; however, it could not be clearly specified whether the chemical changes were of homogeneous or heterogeneous character. The effects of 03 and 03 /limonene in interaction with surface materials in the offices over seven weeks showed different reaction pattems depending material and treatment.
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| 4. |
- Knudsen, J.F., et al.
(author)
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The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II
- 2004
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In: Inflammation. - : Springer Science and Business Media LLC. - 0360-3997 .- 1573-2576. ; 28:5, s. 285-290
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Journal article (peer-reviewed)abstract
- Cyclooxygenase-2 (COX-2) is up-regulated in stromal and inflammatory cells. The inducible COX-2 isoform is expressed during inflammation, in some cancers, and in brain tissue after global and focal ischemia. Tissue acidosis is a dominant factor in inflammation, and contributes to pain and hyperalgesia. Recently, compelling epidemiological and clinical evidence has documented the COX-independent effects of some COX-2 inhibitors (i.e., celecoxib, valdecoxib, and rofecoxib), among these effects are carbonic anhydrase (CA) inhibition. Carbonic anhydrases are zinc metalloenzymes expressed in various cell types, including those of the kidney, where they act as general acid-base catalysts. The kidneys are also known to express the highest concentration of COX-2 messenger ribonucleic acid. Celecoxib, like the prototypic CA inhibitor acetazolamide, is structurally characterized by an unsubstituted sulfonamide moiety. In the present study, we report that celecoxib exhibits the characteristics of a potent CA inhibitor, showing inhibitory human carbonic anhydrase II (hCAII) activity in the nanomolar range. Valdecoxib was relatively less potent. Rofecoxib, which lacks the unsubstituted sulfonamide moiety characteristic of CA inhibitors, showed no significant hCAII inhibitory activity. The current study corroborates our earlier report of structure-activity relationships as predictors of such metabolic events as hyperchloremia, acidosis, and changes in calcium and phosphate disposition, and clinical manifestations associated with CA inhibition reported with celecoxib. These data showing inhibition of hCAII by the unsubstituted sulfonamides celecoxib and valdecoxib, but not by rofecoxib, may have important implications for the elucidation of the mechanisms of action as well as the side effects associated with COX-2 inhibitors. © 2004 Springer Science+Business Media, Inc.
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- Thybo H, Janik T, Omelchenko VD, Grad M, Garetsky RG, Belinsky AA, Karatayev GI, Zlotski G, Knudsen ME, Sand R, Yliniemi J, Tiira T, Luosto U, Komminaho K, Giese R, Guterch A, Lund CE, Kharitonov OM, Ilchenko T, Lysynchuk DV, Skobelev VM, Doody JJ.
(author)
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Upper lithospheric seismic velocity structure across the Pripyat Trough and the Ukrainian Shield along the EUROBRIDGE'97 profile.
- 2003
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In: TECTONOPHYSICS. ; 371, s. 41-79
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Journal article (peer-reviewed)
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