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- Kueppers, Michael, et al.
(author)
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Triple F-a comet nucleus sample return mission
- 2009
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In: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 809-847
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Journal article (peer-reviewed)abstract
- The Triple F (Fresh From the Fridge) mission, a Comet Nucleus Sample Return, has been proposed to ESA's Cosmic Vision program. A sample return from a comet enables us to reach the ultimate goal of cometary research. Since comets are the least processed bodies in the solar system, the proposal goes far beyond cometary science topics (like the explanation of cometary activity) and delivers invaluable information about the formation of the solar system and the interstellar molecular cloud from which it formed. The proposed mission would extract three sample cores of the upper 50 cm from three locations on a cometary nucleus and return them cooled to Earth for analysis in the laboratory. The simple mission concept with a touch-and-go sampling by a single spacecraft was proposed as an M-class mission in collaboration with the Russian space agency ROSCOSMOS.
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- Gimm, O, et al.
(author)
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[Prophylactic parathyroidectomy for familial parathyroid carcinoma].
- 2006
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In: Der Chirurg. - : Springer Science and Business Media LLC. - 0009-4722 .- 1433-0385. ; 77:1, s. 15-24
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Journal article (peer-reviewed)abstract
- In contrast to primary hyperparathyroidism, parathyroid carcinoma is a rare disease. In patients with hyperparathyroidism jaw tumor (HPT-JT) syndrome, caused by germline mutations in HRPT2, the development of parathyroid carcinoma is estimated to be 10-15%. This review summarizes the clinical and molecular genetic data of about 100 patients in the literature and three of our own cases. Unfortunately, osteofibromas, which might enable timely diagnosis of HPT-JT syndrome, occur in only about 30% of patients; about 80% have uniglandular disease. Based on the current data, a general recommendation to perform prophylactic parathyroidectomy cannot be given. However, thorough screening of patients at risk is mandatory. Of note in patients thought to have sporadic parathyroid carcinoma, germline HRPT2 mutations are found in up to 20%. Hence, any patient with parathyroid carcinoma should undergo HRPT2 mutation analysis.
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- Sumpter, David J. T., et al.
(author)
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Consensus Decision Making by Fish
- 2008
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In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 18:22, s. 1773-1777
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Journal article (peer-reviewed)abstract
- Decisions reached through consensus are often more accurate, because they efficiently utilize the diverse information possessed by group members [1-3]. A trust in consensus decision making underlies many of our democratic political and judicial institutions [4], as well as the design of web tools such as Google, Wikipedia, and prediction markets [5, 6]. In theory, consensus for the option favored by the majority of group members will lead to improved decision-making accuracy as group size increases [2, 4]. Although group-living animals are known to utilize social information [7-10], little is known about whether or not decision accuracy increases with group size. In order to reach consensus, group members must be able to integrate the disparate information they possess. Positive feedback, resulting from copying others, can spread information quickly through the group, but it can also result in all individuals making the same, possibly incorrect, choice [8,11,12]. On the other hand, if individuals never copy each other, their decision making remains independent and they fail to benefit from information exchange [4]. Here, we show how small groups of sticklebacks (Gasterosteus aculeatus) reach consensus when choosing which of two replica fish to follow. As group size increases, the fish make more accurate decisions, becoming better at discriminating subtle phenotypic differences of the replicas. A simple quorum rule proves sufficient to explain our observations, suggesting that animals can make accurate decisions without the need for complicated comparison of the information they possess. Furthermore, although submission to peers can lead to occasional cascades of incorrect decisions, these can be explained as a byproduct of what is usually accurate consensus decision making.
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- Ward, Ashley J. W., et al.
(author)
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Quorum decision-making facilitates information transfer in fish shoals
- 2008
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 105:19, s. 6948-6953
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Journal article (peer-reviewed)abstract
- Despite the growing interest in collective phenomena such as "swarm intelligence" and "wisdom of the crowds," little is known about the mechanisms underlying decision-making in vertebrate animal groups. How do animals use the behavior of others to make more accurate decisions, especially when it is not possible to identify which individuals possess pertinent information? One plausible answer is that individuals respond only when they see a threshold number of individuals perform a particular behavior. Here, we investigate the role of such "quorum responses" in the movement decisions of fish (three-spine stickleback, Gasterosteus aculeatus). We show that a quorum response to conspecifics can explain how sticklebacks make collective movement decisions, both in the absence and presence of a potential predation risk. Importantly our experimental work shows that a quorum response can reduce the likelihood of amplification of nonadaptive following behavior. Whereas the traveling direction of solitary fish was strongly influenced by a single replica conspecific, the replica was largely ignored by larger groups of four or eight sticklebacks under risk, and the addition of a second replica was required to exert influence on the movement decisions of such groups. Model simulations further predict that quorum responses by fish improve the accuracy and speed of their decision-making over that of independent decision-makers or those using a Weak linear response. This study shows that effective and accurate information transfer in groups may be gained only through nonlinear responses of group members to each other, thus highlighting the importance of quorum decision-making.
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