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Träfflista för sökning "WFRF:(Kristensen C. A.) srt2:(2015-2019)"

Search: WFRF:(Kristensen C. A.) > (2015-2019)

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  • Jiang, X., et al. (author)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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  • 2019
  • Journal article (peer-reviewed)
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  • Result 1-10 of 87
Type of publication
journal article (84)
conference paper (3)
Type of content
peer-reviewed (81)
other academic/artistic (6)
Author/Editor
Hall, P (46)
Bolla, MK (46)
Chang-Claude, J (46)
Czene, K (45)
Easton, DF (45)
Brenner, H (44)
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Wang, Q. (44)
Giles, GG (44)
Dunning, AM (44)
Fasching, PA (44)
Couch, FJ (44)
Burwinkel, B (44)
Hopper, JL (43)
Cox, A (43)
Dennis, J (42)
Michailidou, K (42)
Southey, MC (41)
Brauch, H (41)
Garcia-Closas, M (41)
Nevanlinna, H (41)
Dork, T (41)
Hamann, U (40)
Schmidt, MK (40)
Beckmann, MW (40)
Mannermaa, A (40)
Lambrechts, D (40)
Milne, RL (39)
Margolin, S (39)
Tomlinson, I (39)
Lindblom, A (38)
Lubinski, J (38)
Chenevix-Trench, G (38)
Andrulis, IL (37)
Haiman, CA (37)
Pharoah, PDP (37)
Benitez, J. (36)
Bojesen, SE (36)
Winqvist, R (36)
Devilee, P (36)
Jakubowska, A (36)
Sawyer, EJ (36)
Zheng, W. (35)
Kosma, VM (35)
Figueroa, J (35)
Guenel, P (34)
Rudolph, A (34)
Meindl, A (34)
Anton-Culver, H (33)
Arndt, V (33)
Simard, J (33)
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University
Karolinska Institutet (71)
Uppsala University (26)
Lund University (21)
University of Gothenburg (9)
Umeå University (5)
Chalmers University of Technology (4)
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Stockholm University (3)
Linköping University (3)
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Swedish Museum of Natural History (1)
Swedish University of Agricultural Sciences (1)
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Language
English (87)
Research subject (UKÄ/SCB)
Medical and Health Sciences (40)
Natural sciences (9)
Engineering and Technology (1)
Agricultural Sciences (1)

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