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Träfflista för sökning "WFRF:(Kristensen E) srt2:(2005-2009)"

Search: WFRF:(Kristensen E) > (2005-2009)

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  • Lange, S, et al. (author)
  • The kinase domain of titin controls muscle gene expression and protein turnover
  • 2005
  • In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 308:5728, s. 1599-1603
  • Journal article (peer-reviewed)abstract
    • The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation. Nbr1 targets the ubiquitin-associated p62/SQSTM1 to sarcomeres, and p62 in turn interacts with MuRF2, a muscle-specific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcription factor (SRF). Nuclear translocation of MuRF2 was induced by mechanical inactivity and caused reduction of nuclear SRF and repression of transcription. A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway.
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  • Result 1-10 of 26
Type of publication
journal article (23)
conference paper (3)
Type of content
peer-reviewed (25)
other academic/artistic (1)
Author/Editor
Silber, Sigmund (9)
Tendera, Michal (8)
Widimsky, Petr (8)
Dean, Veronica (8)
Filippatos, Gerasimo ... (8)
De Caterina, Raffael ... (8)
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Dickstein, Kenneth (8)
Sechtem, Udo (8)
Funck-Brentano, Chri ... (8)
Vahanian, Alec (8)
McGregor, Keith (8)
Hellemans, Irene (8)
Zamorano, Jose Luis (7)
Camm, John (7)
Kristensen, Steen Da ... (5)
Priori, Silvia G (5)
Blomström-Lundqvist, ... (4)
Linde, Cecilia (4)
Kristensen, J (4)
Drexler, Helmut (4)
Auricchio, Angelo (4)
Gasparini, Maurizio (4)
Vardas, Panos E (4)
Blanc, Jean-Jacques (4)
Oto, Ali (4)
Brignole, Michele (4)
Cleland, John (4)
Sutton, Richard (4)
Le Heuzey, Jean-Yves (4)
Daubert, Jean-Claude (4)
Tendera, M (3)
Nilsson, Peter M (3)
Laurent, Stephane (3)
Lindholm, Lars H (3)
Viigimaa, Margus (3)
De Backer, Guy (3)
Fagard, Robert (3)
Cifkova, Renata (3)
Redon, Josep (3)
Narkiewicz, Krzyszto ... (3)
Grassi, Guido (3)
Kjeldsen, Sverre E. (3)
Schmieder, Roland E. (3)
Dalby Kristensen, St ... (3)
Dominiczak, Anna (3)
Kristensen, S. D. (3)
Silber, S. (3)
Zanchetti, Alberto (3)
Rynkiewicz, Andrzej (3)
Ruilope, Luis (3)
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University
Uppsala University (10)
Karolinska Institutet (9)
University of Gothenburg (5)
Umeå University (3)
Linköping University (3)
Lund University (3)
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Stockholm University (1)
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Language
English (24)
Polish (1)
Portuguese (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (5)
Natural sciences (2)
Engineering and Technology (1)

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