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- Fischer, Johannes, et al.
(author)
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Observer agreement of imaging measurements used for evaluation of dentofacial deformity in juvenile idiopathic arthritis
- 2022
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In: Dento-Maxillo-Facial Radiology. - : British Institute of Radiology. - 0250-832X .- 1476-542X. ; 51:6
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Journal article (peer-reviewed)abstract
- Objectives:To examine the precision of imaging measures commonly used to assess mandibular morphology in children and adolescents with juvenile idiopathic arthritis (JIA). Secondly, to compare cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in the measurement of condylar height.Methods:Those included were children diagnosed with JIA during 2015–18 who had had an MRI, a CBCT of the temporomandibular joints (TMJs) and a lateral cephalogram (ceph) of the head within one month of each other. Agreement within and between observers and methods was examined using Bland-Altman mean-difference plots and 95% limits of agreement (LOA). A 95% LOA within 15% of the sample mean was considered acceptable. Minimal detectable change (MDC) within and between observers was estimated.Results:90 patients (33 males) were included, with a mean age of 12.8 years. For MRI, intra- and interobserver 95% LOA were relatively narrow for total mandibular length: 9.6% of the sample mean. For CBCT, condylar height, both intra- and interobserver 95% LOA were wide: 16.0 and 28.4% of the sample mean, respectively. For ceph, both intra- and interobserver 95% LOA were narrow for the SNA-angle and gonion angle: 5.9 and 8% of the sample mean, and 6.2 and 6.8%, respectively.Conclusions:We have identified a set of precise measurements for facial morphology assessments in JIA, including one MRI-based (total mandibular length), one CBCT-based (condylar height), and three ceph-based. Condylar height was higher for MRI than for CBCT; however, the measurement was too imprecise for clinical use. MDC was also determined for a series of measurements.
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- Giannopoulos, Filippos, et al.
(author)
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Methotrexate Use for Patients with Psoriasis and Risk of Cutaneous Squamous Cell Carcinoma: A Nested Case-control Study.
- 2021
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In: Acta dermato-venereologica. - : Medical Journals Sweden AB. - 1651-2057. ; 101:1
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Journal article (peer-reviewed)abstract
- An association between methotrexate use and risk of cutaneous squamous cell carcinoma has been reported in patients with rheumatoid and psoriatic arthritis. A nested case-control study was performed to investigate if methotrexate use among patients with psoriasis was associated with increased risk of cutaneous squamous cell carcinoma. Data were obtained from Swedish egisters and included 623 patients with psoriasis and a first cutaneous squamous cell carcinoma from 2010 to 2016. Ten randomly selected patients with psoriasis were matched on age and sex to each case. Among cases, 160 (26%) were ever-users of metho-trexate. The corresponding number among the controls was 1,370 (22%), yielding an unadjusted odds ratio (OR) of 1.23 (95% confidence interval (95% CI) 1.02-1.49); p=0.034. After adjusting for use of other immunosuppressive drugs the association was close to unity (OR 1.09; 95% CI 0.89-1.34); p=0.39. The slightly increased risk of cutaneous squamous cell carcinoma associated with methotrexate-exposure in patients with psoriasis does not seem to be associated with metho-trexate, but rather with disease severity, other anti-psoriatic treatments, and ultraviolet (UV) exposure.
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- Kristensen, Kasper, 1985-
(author)
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Spinoza on Ethical Cultivation : An Analysis of Vulnerability, Empowerment, and Early Modern Cultura Animi
- 2023
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Doctoral thesis (other academic/artistic)abstract
- This dissertation concerns Benedict Spinoza’s (1632–1677) account of ethical life, emphasising the role of techniques and exercises for achieving greater power to control one’s thoughts, emotions, and actions. The study aims to show that Spinoza offers a much more coherent and ambitious ethical theory than what is commonly acknowledged, involving both theoretical and practical considerations.The primary focus of the dissertation is to trace the influence of the early modern cultura animi (cultivation of the soul) tradition on Spinoza’s moral philosophy and to explore the novel use to which he puts it. Chapter One relates the central aims of Spinoza’s philosophy to a conception of philosophy as the art of living, connecting the Renaissance humanist revival of cultura animi tradition to Spinoza’s own attempt to construct a scientific ethics. Chapter Two analyses how Spinoza’s theories of imagination, judgment, and emotions explain the deep-rooted habits and prejudices that present key obstacles to ethical progress. Taking this diagnosis of human nature as a point of departure, Chapter Three explores the difficulties involved in trying to attain adequate knowledge and argues that Spinoza constructs his philosophical method to remedy the natural weakness of human understanding. Chapter Four explains Spinoza’s account of the central moral concepts of good and evil, articulating and defending an objectivist reading of his value theory. Chapter Five considers the extent to which a rational understanding of good and evil can alter habits and guide action given that passions are often more powerful than reason. Building on the weakness of reason to control the passions, Chapter Six shows that spiritual exercises are necessary components in Spinoza’s proposed remedy insofar as they fortify rational understanding by producing firm habits of character. The concluding discussion underlines that Spinoza’s ethical cultivation should not be seen as a linear process that secures stable happiness. Rather, people are and remain subject to the power of illusory beliefs and passions, and the ethical struggle is ongoing. By cultivating understanding, modifying one’s desires, reforming vicious habits and performing virtuous actions, however, the individual can learn to live with his or her vulnerability more happily and virtuously.
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- Polesie, Sam, et al.
(author)
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Use of methotrexate and risk of skin cancer: a nationwide case-control study.
- 2023
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In: British journal of cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 128:7, s. 1311-1319
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Journal article (peer-reviewed)abstract
- Methotrexate (MTX) use has been suspected of increasing the risk of skin cancer. The aim of this investigation was to examine the association between the use of MTX and the risk of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC) and cutaneous malignant melanoma (CMM).In a nationwide Danish case-control study, we identified incident, histologically verified cases of BCC (n=131,447), cSCC (n=18,661) or CMM (26,068) from 2004 to 2018. We matched 10 controls to each case on sex and birth year using risk-set sampling and computed crude and adjusted odds ratios (ORs) using conditional logistic regression for the use of MTX (≥2.5g) compared with never-use.Use of MTX was associated with increased risk of BCC, cSCC and CMM with adjusted ORs of (95% confidence interval) 1.29 (1.20-1.38), 1.61 (1.37-1.89) and 1.35 (1.13-1.61), respectively. For BCC and cSCC, ORs increased with higher cumulative doses. When restricting the study population to patients with psoriasis, the ORs were 1.43 (1.23-1.67), 1.18 (0.80-1.74) and 1.15 (0.77-1.72), respectively.We observed an increased risk of BCC and cSCC associated with the use of MTX with evidence of a dose-response pattern; however, the association was not consistent when restricting the study population to patients with psoriasis.
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- Poulsen, Kasper, et al.
(author)
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Entanglement-enhanced quantum rectification
- 2022
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In: Physical Review A: covering atomic, molecular, and optical physics and quantum information. - 2469-9926 .- 2469-9934. ; 105:5
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Journal article (peer-reviewed)abstract
- Quantum mechanics dictates the band structure of materials that is essential for functional electronic components. With increased miniaturization of devices, it becomes possible to exploit the full potential of quantum mechanics through the principles of superposition and entanglement. We propose a class of quantum rectifiers that can leverage entanglement to dramatically increase performance by coupling two small spin chains through an effective double-slit interface. Simulations show that rectification is enhanced by several orders of magnitude even in small systems, and that the effect survives in a noisy environment. Realizable using several of the quantum technology platforms currently available, our findings reveal the importance of quantum entanglement in seemingly contradictory applications such as heat and noise control.
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| 7. |
- Stoustrup, Peter, et al.
(author)
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Management of orofacial manifestations of juvenile idiopathic arthritis : Interdisciplinary consensus-based recommendations.
- 2023
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In: Arthritis & Rheumatology. - : John Wiley & Sons. - 2326-5191 .- 2326-5205. ; 75:1, s. 4-14
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Research review (peer-reviewed)abstract
- OBJECTIVES: Involvement of the temporomandibular joint (TMJ) is common in juvenile idiopathic arthritis (JIA). TMJ arthritis can lead to orofacial symptoms, dysfunction and dentofacial deformity with negative impact on quality of life. Management involves interdisciplinary collaboration. No current recommendations exist to guide clinical management.OBJECTIVES: 1) To develop consensus-based interdisciplinary recommendations for management of orofacial manifestations of JIA. 2) To create a future research agenda related to management of TMJ arthritis in children with JIA.METHODS: The recommendations were developed using online surveying of relevant stakeholders, systematic literature review, evidence-informed generation of recommendations during two consensus-meetings, and Delphi study iterations involving external experts. The process included disciplines involved in the care of orofacial manifestations of JIA: Pediatric rheumatology, radiology, orthodontics, oral and maxillofacial surgery, orofacial pain specialists and pediatric dentistry. Recommendations were accepted if agreement was >80% during a final Delphi study.RESULTS: Three overarching management principles and 12 recommendations for interdisciplinary management of orofacial manifestations of JIA were outlined. The 12 recommendations pertained to: diagnosis (n=4), treatment of TMJ arthritis (active TMJ inflammation) (n=2), treatment of TMJ dysfunction and symptoms (n=3), treatment of arthritis-related dentofacial deformity (n=2), and other related aspects to JIA (n=1). Additionally, a future interdisciplinary research agenda was developed.CONCLUSIONS: These are the first interdisciplinary recommendations to guide clinical management of TMJ JIA. The 3 overarching principles and 12 recommendations fill an important gap in current clinical practice. They emphasize the importance of an interdisciplinary approach to diagnosis and management of orofacial manifestations of JIA. This article is protected by copyright. All rights reserved.
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