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1.	Bousquet, J, et al. (author) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) 2008 In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 6363 Suppl 86, s. 8- Journal article (peer-reviewed)
2.	Kuna, P., et al. (author) Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma 2006 In: Respiratory Medicine. - : Elsevier BV. - 1532-3064 .- 0954-6111. ; 100:12, s. 2151-2159 Journal article (peer-reviewed)abstract Adherence to maintenance therapy is often poor in patients with asthma. Simplifying dosing regimens has the potential to improve both adherence and asthma-retated morbidity. In this 12-week, randomized, double-blind, double-dummy, parattel-group study, 617 patients with mild to moderate persistent asthma (mean forced expiratory volume in 1 s [FEV,] 78.5% predicted) who were not optimally controlled on inhaled corticosteroids (200-500pg/day) were randomized to once-daily budesonide/formoterot (80/4.5 tg, 2 inhalations in the evening), twice-daity budesonide/formoterol (80/4.5 pg, 1 inhalation), or a corresponding dose of budesonide once-daily (200pg, 1 inhalation in the evening). AR patients received budesonide (100pg twice daily) during a 2-week run-in. Changes in mean morning peak expiratory flow (PEF) were similar for od budesonide/formoterol (23.4 l/min) and twice-daily budesonide/formoterot (24.1 l/min), and both were greater than with budesonide (5.5 Unnin; both P < 0.001). Evening PEF, symptom-free days, reliever-free days, and asthma control days were improved with budesonide/ formoterol therapy vs. budesonide (P < 0.05 vs. budesonide for all variables). All treatments were well tolerated. Budesonide/formoterot administered once daily in the evening is a convenient treatment regimen that is as effective in improving asthma control as twice-daily dosing in patients with mild to moderate persistent asthma. (c) 2006 Elsevier Ltd. All rights reserved.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Chen, Y. (1); Price, D. (1); Li, J. (1); Mohammad, Y (1); Bachert, C (1); Ohta, K. (1); show more...; Bousquet, J (1); Johnston, SL (1); Rabe, KF (1); Williams, D. (1); Demoly, P. (1); Papadopoulos, N (1); Agache, I (1); Wickman, M (1); Vogelmeier, C (1); Niggemann, B. (1); Simons, FER (1); Zuberbier, T (1); Lindqvist, A (1); Humbert, M. (1); Scadding, GK (1); Yorgancioglu, A (1); Wang, DY (1); Carlsen, KH (1); Canonica, GW (1); Passalacqua, G (1); Burney, P. (1); Annesi-Maesano, I (1); Kowalski, ML (1); Palkonen, S (1); Jackson, C (1); Kemp, JP (1); Ait-Khaled, N (1); BATEMAN, ED (1); Mullol, J (1); Bonini, S (1); Larenas-Linnemann, D (1); Pawankar, R (1); Fokkens, WJ (1); Meltzer, EO (1); Naclerio, R (1); van Cauwenberge, P (1); Toskala, E. (1); Nizankowska-Mogilnic ... (1); Blaiss, MS (1); Durham, SR (1); Busse, WW (1); Nihlén, Ulf (1); Viegi, G (1); Cruz, AA (1); show less...

University: Lund University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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