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- Armerin, Fredrik, 1971-, et al.
(author)
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Competitive investment with varying risk premia
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Other publication (other academic/artistic)abstract
- This paper considers a model with a time-varying risk premium. The risk premium is driven by a continuous time Markov chain, representing the state in the economy, and the stochastic process generating the cash flows is a Markov-modulated geometric Brownian motion. An existing firm is facing the possibility of competitors entering the market, and due to this, cash flows are limited at levels which are dependent on the state of the economy. This results in a regulated Markov-modulated geometric Brownian motion, and the resulting accumulated supply can have jumps, something that is not possible in a model with only one regime.
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- Macao, Bertil, 1969
(author)
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Mechanisms for control of nucleoside triphosphate hydrolysis. Effects of DNA and RNA co-factors
- 2002
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Doctoral thesis (other academic/artistic)abstract
- In energetically unfavourable biological processes "protein machines" utilize chemical energy from the hydrolysis of high-energy phosphate bonds. Thus, the hydrolysis of a nucleoside triphosphate (NTP) to nucleoside diphosphate (NDP) with the release of free orthophosphate results in a liberation of energy. In addition, proteins that work as switches or gates in order to ensure fidelity and directionality to many synthetic and signal transduction processes also use NTP hydrolysis. This thesis describes the studies of the mechanisms involved in controlling the GTP and ATP binding and hydrolysis by the Ffh and FtsY proteins from the bacterial Signal Recognition Particle, SRP, and the origin binding protein, OBP, or UL9 from the Herpes simplex virus type 1 replication machinery.The Ffh and FtsY proteins from Mycoplasma mycoides are unusual GTPases because they act as GAPs for each other. We show that the reciprocal GTPase stimulation occurs when the G-domains of the proteins are combined in vitro. This finding indicates that important elements of the basic GTPase activation mechanism reside in the G-domains as such and that the other domains of Ffh and FtsY only serve to modulate the activation. We also show that binding of GTP to Ffh results in significant conformational changes of the protein. In particular, a region near the C-terminus of the G-domain becomes more ordered as a result of nucleotide binding. This region is close to sites where the G-domain interacts with other domains of the protein. Therefore, the structural changes that we observe may be part of a mechanism where GTP binding induces conformational changes in other domains of Ffh.OBP acts as the initiator for replication of the HSV-1 genome. It acts by converting the double-stranded origin of DNA replication oriS to an activated partially single-stranded conformation referred to as oriS*. The reaction requires ATP hydrolysis. We demonstrate genetically that oriS* most likely is formed in vivo. We also show that oriS* is an efficient activator of ATP hydrolysis and that stimulation of ATP hydrolysis requires binding to a hairpin containing the recognition sequence for OBP and position-specific base-contacts with a 3' single-stranded tail. Gel retardation experiments indicate furthermore that OBP adopts different conformations in the presence of ATP or ADP.Finally, the diverse roles that RNA and DNA have on regulation of hydrolysis of nucleoside triphosphates are discussed.
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- Rodhe, Ioana, et al.
(author)
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n-LDA : n-Layers Data Aggregation in Sensor Networks
- 2008
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In: Proc. 28th International Conference on Distributed Computing Systems Workshops. - Piscataway, NJ : IEEE. - 9780769531731 ; , s. 400-405
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Conference paper (peer-reviewed)
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| 8. |
- Hansen, Soren, et al.
(author)
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Benign paroksysmal positionel vertigo--den hyppigste form for otogen vertigo
- 2007
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In: Ugeskrift for Læger. - 0041-5782. ; 169:21, s. 1996-2002
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Journal article (peer-reviewed)abstract
- Benign paroxysmal positional vertigo presents with brief, episodic, positioning-provoked vertigo and characteristic findings on Dix-Hallpike and other positional tests. This article is based on a systematic review of the literature and describes epidemiology, etiology, pathogenesis, diagnostic positional tests and treatment using canalith repositioning, liberatory and 360 degrees rotation manoeuvres. Diagnostic pitfalls, mastoid vibration, postmanoeuvre activity restriction and the ideal number of repositioning manoeuvres per treatment session are discussed.
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| 9. |
- Kihlström, Caroline, et al.
(author)
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Surgical Versus Nonsurgical Treatment of Lateral Clavicle Fractures : A Short-Term Follow-Up of Treatment and Complications in 122 Patients.
- 2021
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In: Journal of Orthopaedic Trauma. - : Wolters Kluwer. - 0890-5339 .- 1531-2291. ; 35:12, s. 667-672
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Journal article (peer-reviewed)abstract
- OBJECTIVES: To assess the total number of procedures in initially surgically and nonsurgically treated patients with lateral clavicle fractures and to compare patient-reported outcome measures (PROMs).DESIGN: Retrospective cohort study.SETTING: Level 1 trauma center.PATIENTS: One hundred twenty-two patients with lateral clavicle fractures treated at Uppsala University Hospital from 2013 to 2015 were included in a patient record review. A subgroup of 30 patients was assessed at a study follow-up visit at a median of 3 years postinjury.INTERVENTION: Comparisons between initially surgically and nonsurgically treated patients.MAIN OUTCOME MEASUREMENTS: Rates of surgical treatment, reoperations, and delayed surgeries. PROM subgroup: Constant score; Disabilities of the Arm, Shoulder and Hand score; and Visual Analog Scale over satisfaction with the cosmetic results and interview-based information on subjective complaints and reflections.RESULTS: Of 23 surgically treated patients (22 Neer type II and V fractures), 10 underwent subsequent implant removal, after which 1 developed symptomatic nonunion. Of 99 nonsurgically treated patients (36 Neer type II and V fractures), 2 underwent delayed surgery because of symptomatic nonunion. In the PROM subgroup, the surgically treated patients had worse Constant scores, complained of infraclavicular sensory deficits, and were less satisfied with the cosmetic result than the nonsurgically treated patients.CONCLUSIONS: Half of the surgically treated patients underwent implant removal, whereas delayed surgeries in nonsurgically treated patients were very rare. Nonsurgical treatment should be considered more often as an alternative to surgery even for the usually surgically treated Neer type II and V lateral clavicle fractures.LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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- Li, Yongwei, 1990-, et al.
(author)
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Depth-Assisted Light Field Super-Resolution in Layered Object Space
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Other publication (other academic/artistic)abstract
- The captured light field may fail to reconstruct fine details of the scene due to under-sampling problem of lightfield acquisition devices. Therefore,super-resolution is required to restore high-frequency information from the light field and to improve the quality of therendered views. Conventionalsuper-resolution algorithms are not ideal for light field data, as they do not utilize the full potential of light field 4D structure, while existing light fieldsuper-resolution algorithms rely heavily on the accuracy of the estimated depth and perform complex sub-pixeldisparity estimation. In this paper, we propose a new light field super-resolution algorithm which can address depthuncertainty with a layered object space. First, a pixel-wise depth estimation is performed from the resampled views.Then we divide the depth range into finite layers and back-project pixels onto these layers in order to address the sub-pixel depth error. Finally, two super-resolution schemes: in-depth warping and cross-depth learning, are introduced tosuper-resolve the views from light field data redundancy. The algorithms is tested with extensive datasets, and theresults show that our method attains favorable results in both visual assessment and objective metrics compared toother light field super-resolution methods.
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