| 1. |
- Kattge, Jens, et al.
(author)
-
TRY plant trait database - enhanced coverage and open access
- 2020
-
In: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
-
Journal article (peer-reviewed)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
|
|
| 2. |
|
|
| 3. |
- Khatri, C, et al.
(author)
-
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
-
In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
-
Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
|
|
| 4. |
- Bravo, L, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 5. |
|
|
| 6. |
- Tabiri, S, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 7. |
|
|
| 8. |
- Eisenberg, Michael L., et al.
(author)
-
Male infertility
- 2023
-
In: Nature Reviews Disease Primers. - 2056-676X. ; 9:1
-
Research review (peer-reviewed)abstract
- Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation of male infertility includes detailed history taking, focused physical examination and selective laboratory testing, including semen analysis. Treatments include lifestyle optimization, empirical or targeted medical therapy as well as surgical therapies that lead to measurable improvement in fertility. Although male infertility is recognized as a disease with effects on quality of life for both members of the infertile couple, fewer data exist on specific quantification and impact compared with other health-related conditions.
|
|
| 9. |
- Lamb, Maurice, et al.
(author)
-
Forward and Backward Reaching Inverse Kinematics (FABRIK) solver for DHM : A pilot study
- 2022
-
In: Proceedings of the 7th International Digital Human Modeling Symposium (DHM 2022), August 29–30, 2022, Iowa City, Iowa, USA. - : University of Iowa Press. - 9780984037841 ; , s. 1-11
-
Conference paper (peer-reviewed)abstract
- Posture/motion prediction is the basis of the human motion simulations that make up the core of many digital human modeling (DHM) tools and methods. With the goal of producing realistic postures and motions, a common element of posture/motion prediction methods involves applying some set of constraints to biomechanical models of humans on the positions and orientations of specified body parts. While many formulations of biomechanical constraints may produce valid predictions, they must overcome the challenges posed by the highly redundant nature of human biomechanical systems. DHM researchers and developers typically focus on optimization formulations to facilitate the identification and selection of valid solutions. While these approaches produce optimal behavior according to some, e.g., ergonomic, optimization criteria, these solutions require considerable computational power and appear vastly different from how humans produce motion. In this paper, we take a different approach and consider the Forward and Backward Reaching Inverse Kinematics (FABRIK) solver developed in the context of computer graphics for rigged character animation. This approach identifies postures quickly and efficiently, often requiring a fraction of the computation time involved in optimization-based methods. Critically, the FABRIK solver identifies posture predictions based on a lightweight heuristic approach. Specifically, the solver works in joint position space and identifies solutions according to a minimal joint displacement principle. We apply the FABRIK solver to a seven-degree of freedom human arm model during a reaching task from an initial to an end target location, fixing the shoulder position and providing the end effector (index fingertip) position and orientation from each frame of the motion capture data. In this preliminary study, predicted postures are compared to experimental data from a single human subject. Overall the predicted postures were very near the recorded data, with an average RMSE of 1.67°. Although more validation is necessary, we believe that the FABRIK solver has great potential for producing realistic human posture/motion in real-time, with applications in the area of DHM.
|
|
| 10. |
|
|
