| 1. |
- Soranzo, Nicole, et al.
(author)
-
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
- 2009
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:11, s. 38-1182
-
Journal article (peer-reviewed)abstract
- The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
|
|
| 2. |
- Cockell, C.S., et al.
(author)
-
Darwin - an experimental astronomy mission to search for extrasolar planets
- 2009
-
In: Experimental Astronomy. - 0922-6435 .- 1572-9508. ; 23:1, s. 435-461
-
Journal article (peer-reviewed)abstract
- As a response to ESA call for mission concepts for its Cosmic Vision 2015–2025 plan, we propose a mission called Darwin. Its primary goal is the study of terrestrial extrasolar planets and the search for life on them. In this paper, we describe different characteristics of the instrument.
|
|
| 3. |
- Suchodolskis, A., et al.
(author)
-
Photoemission and optical spectroscopy of i-ZnMgEr quasicrystal
- 2005
-
In: Acta Physica Polonica. A. - 0587-4246 .- 1898-794X. ; 107:2, s. 412-419
-
Journal article (peer-reviewed)abstract
- The results of photoemission and optical studies of icosahedral single-grain ZnMgEr quasicrystals are presented. Synchrotron radiation photoemission measurements were performed on in situ cleaved samples at 10(-10) mbar pressure and low, 140-150 K temperature. The valence band photoemission spectra measured reveal a simple metal-type valence band of icosahedral ZnMgEr with a distinct Fermi edge cut-off and with a sharp pseudogap feature. The photoemission spectra of shallow Mg 2p and Zn 3d core levels indicate a coordination shift of Mg 2p spin-orbit doublet and an oscillating dependence of Zn 3d photoemission line components on the photon energy within the hv = 20-160 eV range investigated. The optical response of icosahedral ZnMgEr, a dispersion of the dielectric function, was measured by the spectroscopic ellipsometry technique in the 0.5-5.0 eV spectral range. The optical spectra of the quasicrystal indicate the Drude-type optical response superimposed with a peak of interband optical transitions. The interband optical transitions can be modelled with the pseudogap parameters which agree with those deduced in an analysis of the photoemission valence band spectra.
|
|
| 4. |
- Karpus, V., et al.
(author)
-
Coordination-induced structure of the Mg 2p core level in i-ZnMgR quasicrystals
- 2007
-
In: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 76:15
-
Journal article (peer-reviewed)abstract
- We present a detailed analysis of Mg 2p photoemission (PE) spectra in icosahedral ZnMgR (R=Y, Ho, Er) quasicrystals and in the crystalline Zn2Mg Laves phase. Synchrotron-radiation PE measurements were performed on in situ cleaved single-grain samples at 10(-10) mbar pressure and low, 90-150 K, temperature. The analysis of Mg 2p PE spectra in Zn2Mg reveals a surface shift of the core level of -0.12 eV. The Mg 2p PE spectra in i-ZnMgR quasicrystals are essentially broadened as compared to spectra in Zn2Mg Laves phase. The effect is due to the coordination-induced structure of the Mg 2p levels. Different local surroundings of Mg atoms in quasicrystals induce both different shifts of the Mg 2p level and splittings of its spin-orbit components. The local coordination potential at different Mg sites in the quasicrystalline lattice is calculated on the basis of the face-centered icosahedral ZnMgY atomic structure data, recently determined from the pair distribution function analysis. The coordination shifts calculated are spread within an interval of about 0.3 eV, while the splittings of the 2p(3/2) component are of the order of 1-10 meV. The simulated theoretical Mg 2p PE spectra of fci-ZnMgR quasicrystals perfectly fit the experimental data.
|
|
