| 1. |
- Lindqvist, U, et al.
(author)
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Evaluation of various models of hyaluronan kinetics for assessment of liver function
- 1997
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In: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. - : SCANDINAVIAN UNIVERSITY PRESS. - 0036-5513. ; 57:1, s. 49-58
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Journal article (other academic/artistic)abstract
- The purpose of this study of various models of hyaluronan kinetics has been to find the most appropriate model for estimation of parameters which characterize liver endothelial cell function. Five theoretical models for serum hyaluronan distribution and e
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| 2. |
- Lindqvist, Ulla, et al.
(author)
-
Evaluation of various models of hyaluronan kinetics for assessment of liver function
- 1997
-
In: Scandinavian Journal of Clinical and Laboratory Investigation. - 0036-5513 .- 1502-7686. ; 57:1, s. 49-58
-
Journal article (peer-reviewed)abstract
- The purpose of this study of various models of hyaluronan kinetics has been to find the most appropriate model for estimation of parameters which characterize liver endothelial cell function. Five theoretical models for serum hyaluronan distribution and elimination were evaluated by computer analysis of serial measurements of the mass concentration of hyaluronan in serum following an intravenous bolus dose. Three of the models were based on one-compartment distribution of intravenously injected hyaluronan. Model 1A, with assumed first-order elimination, was found to be compatible with measured data and had identifiable parameters. Model 1B, with assumed non-linear Michaelis-Menten kinetics, was also found to be compatible but the Michaelis-Menten constant (K(m)) was not well determined. In model 1C, with non-linear Michaelis-Menten elimination kinetics, K(m) was set to a fixed value of 340 micrograms l-1, and the remaining parameters were well determined and the model was found to be compatible. Two models with an assumed two-compartment distribution of intravenously injected hyaluronan, were not acceptable due to unidentified parameters not discriminating between patients and healthy persons. In conclusion, model 1C, with one-compartment distribution and non-linear Michaelis-Menten kinetics, best fulfilled the criteria of validity and was accepted for further evaluation of clinical materials.
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| 3. |
- Rasmussen, I, et al.
(author)
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Hepatic extraction of hyaluronic acid in porcine peritonitis
- 1995
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In: European Surgical Research. - : S. Karger AG. - 0014-312X .- 1421-9921. ; 27:1, s. 1-10
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Journal article (peer-reviewed)abstract
- The hepatic extraction of hyaluronic acid (HA) was studied in porcine fecal peritonitis in two groups of animals given various amounts of volume substitution. There was a progressive decrease in hepatic blood flow (QH) and a corresponding increase in the plasma concentration of HA in arterial blood over a 5-hour observation period, less pronounced in animals given more volume substitution. While hepatic clearance of HA decreased, the extraction ratio over the liver was not altered. The extracted amount of HA, which at steady state reflects the turnover of HA, was also unchanged. There was a significant correlation between QH and arterial HA concentration (r = 0.57; p < 0.05). The data suggest that the arterial HA concentration in sepsis reflects QH rather than an altered ability of the liver to eliminate HA.
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