| 1. |
- Adiyaman, Ahmet, et al.
(author)
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Determinants of the ambulatory arterial stiffness index in 7604 subjects from 6 populations
- 2008
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In: Hypertension. - 1524-4563. ; 52:6, s. 1038-44
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Journal article (peer-reviewed)abstract
- The ambulatory arterial stiffness index (AASI) is derived from 24-hour ambulatory blood pressure recordings. We investigated whether the goodness-of-fit of the AASI regression line in individual subjects (r(2)) impacts on the association of AASI with established determinants of the relation between diastolic and systolic blood pressures. We constructed the International Database on the Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (7604 participants from 6 countries). AASI was unity minus the regression slope of diastolic on systolic blood pressure in individual 24-hour ambulatory recordings. AASI correlated positively with age and 24-hour mean arterial pressure and negatively with body height and 24-hour heart rate. The single correlation coefficients and the mutually adjusted partial regression coefficients of AASI with age, height, 24-hour mean pressure, and 24-hour heart rate increased from the lowest to the highest quartile of r(2). These findings were consistent in dippers and nondippers (night:day ratio of systolic pressure >or=0.90), women and men, and in Europeans, Asians, and South Americans. The cumulative z score for the association of AASI with these determinants of the relation between diastolic and systolic blood pressures increased curvilinearly with r(2), with most of the improvement in the association occurring above the 20th percentile of r(2) (0.36). In conclusion, a better fit of the AASI regression line enhances the statistical power of analyses involving AASI as marker of arterial stiffness. An r(2) value of 0.36 might be a threshold in sensitivity analyses to improve the stratification of cardiovascular risk.
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| 2. |
- Boggia, José, et al.
(author)
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Prognostic accuracy of day versus night ambulatory blood pressure : a cohort study
- 2007
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 370:9594, s. 1219-1229
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Journal article (peer-reviewed)abstract
- Background Few studies have formally compared the predictive value of the blood pressure at night over and beyond the daytime value. We investigated the prognostic significance of the ambulatory blood pressure during night and day and of the night-to-day blood pressure ratio. Methods We did 24-h blood pressure monitoring in 7458 people (mean age 56.8 years [SD 13.9]) enrolled in prospective population studies in Denmark, Belgium, Japan, Sweden, Uruguay, and China. We calculated multivariate-adjusted hazard ratios for daytime and night-time blood pressure and the systolic night-to-day ratio, while adjusting for cohort and cardiovascular risk factors. Findings Median follow-up was 9.6 years (5th to 95th percentile 2.5-13.7). Adjusted for daytime blood pressure, night-time blood pressure predicted total (n=983; p<0.0001), cardiovascular (n=387; p<0.01), and non-cardiovascular (n=560; p<0.001) mortality. Conversely, adjusted for night-time blood pressure, daytime blood pressure predicted only non-cardiovascular mortality (p<0.05), with lower blood pressure levels being associated with increased risk. Both daytime and night-time blood pressure consistently predicted all cardiovascular events (n=943; p<0.05) and stroke (n=420; p<0.01). Adjusted for night-time blood pressure, daytime blood pressure lost prognostic significance only for cardiac events (n=525; p >= 0.07). Adjusted for the 24-h blood pressure, night-to-day ratio predicted mortality, but not fatal combined with non-fatal events. Antohypertensive drug treatment removed the significant association between cardiovascular events and the daytime blood pressure. Participants with systolic night-to-day ratio value of 1 or more were older, at higher risk of death, and died at an older age than those whose night-to-day ratio was normal (>= 0.80 to <0.90). Interpretation In contrast to commonly held views, daytime blood pressure adjusted for night-time blood pressure predicts fatal combined with non-fatal cardiovascular events, except in treated patients, in whom antihypertensive drugs might reduce blood pressure during the day, but not at night. The increased mortality in patients with higher night-time than daytime blood pressure probably indicates reverse causality. Our findings support recording the ambulatory blood pressure during the whole day.
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| 3. |
- Hansen, Tine W., et al.
(author)
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Prognostic value of ambulatory heart rate revisited in 6928 subjects from 6 populations
- 2008
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In: Hypertension. - 0194-911X .- 1524-4563. ; 52:2, s. 229-235
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Journal article (peer-reviewed)abstract
- The evidence relating mortality and morbidity to heart rate remains inconsistent. We performed 24-hour ambulatory blood pressure monitoring in 6928 subjects (not on beta-blockers; mean age: 56.2 years; 46.5% women) enrolled in prospective population studies in Denmark, Belgium, Japan, Sweden, Uruguay, and China. We computed standardized hazard ratios for heart rate, while stratifying for cohort, and adjusting for blood pressure and other cardiovascular risk factors. Over 9.6 years (median), 850, 325, and 493 deaths accrued for total, cardiovascular, and noncardiovascular mortality, respectively. The incidence of fatal combined with nonfatal end points was 805, 363, 439, and 324 for cardiovascular, stroke, cardiac, and coronary events, respectively. Twenty-four-hour heart rate predicted total (hazard ratio: 1.15) and noncardiovascular (hazard ratio: 1.18) mortality but not cardiovascular mortality (hazard ratio: 1.11) or any of the fatal combined with nonfatal events (hazard ratio: < or =1.02). Daytime heart rate did not predict mortality (hazard ratio: < or =1.11) or any fatal combined with nonfatal event (hazard ratio: < or =0.96). Nighttime heart rate predicted all of the mortality outcomes (hazard ratio: > or =1.15) but none of the fatal combined with nonfatal events (hazard ratio: < or =1.11). The night:day heart rate ratio predicted total (hazard ratio: 1.14) and noncardiovascular mortality (hazard ratio: 1.12) and all of the fatal combined with nonfatal events (hazard ratio: > or =1.15) with the exception of stroke (hazard ratio: 1.06). Sensitivity analyses, in which we stratified by risk factors or from which we excluded 1 cohort at a time or the events occurring within 2 years of enrollment, showed consistent results. In the general population, heart rate predicts total and noncardiovascular mortality. With the exception of the night:day heart rate ratio, heart rate did not add to the risk stratification for fatal combined with nonfatal cardiovascular events. Thus, heart rate adds little to the prediction of cardiovascular risk.
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| 4. |
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| 5. |
- Kang, Huihui, et al.
(author)
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Hyperfine quenching of the 3s3p^3P_0 state in Mg-like ions
- 2009
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In: Journal of Physics B. - : Bibliopolis, Edizioni di Filosofia e Scienze. - 0953-4075 .- 1361-6455. ; 42:19
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Journal article (peer-reviewed)abstract
- Hyperfine quenching rates of the 3s3p 3P0 level in Mg-like ions were calculated using the GRASP2K package based on the multi-configuration Dirac–Hartree–Fock method. Valence and core-valence correlation effects were accounted for in a systematic way. Breit interactions and QED effects were included in the subsequent relativistic CI calculations. Calculated rates were compared with other theoretical values and with experiment, and a good agreement with the latest experimental value for the 27Al+ ion (Rosenband et al 2007 Phys. Rev. Lett. 98 220801) was found. Furthermore, we showed in detail the contributions from Breit interaction and QED effects to concerned physical properties. Finally, electronic data were presented in terms of a general scaling law in Z that, given isotopic nuclear spin and magnetic moment, allows hyperfine-induced decay rates to be estimated for any isotope along the isoelectronic sequence.
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| 6. |
- Li, Jiguang, et al.
(author)
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Hyperfine induced 1s2s^1S_0 -> 1s^2^1S_0 M1 transition of He-like ions
- 2009
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In: European Physical Journal D. - : EDP Sciences. - 1434-6060 .- 1434-6079. ; 51:3, s. 313-317
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Journal article (peer-reviewed)abstract
- Hyperfine induced SS0 M1 transition probabilities of He-like ions have been calculated from relativistic configuration interaction wavefunctions including the frequency independent Breit interaction and QED effects. Present results for 151Eu and 155Gd are in good agreement with previous calculations [L.N. Labzowsky et al., Phys. Rev. A 63, 054105 (2001)]. Electronic data are given in terms of a general scaling law in Z that, given isotopic nuclear spin and magnetic moment, allows hyperfine induced decay rates to be estimated for any isotope. The results should be helpful for future experimental investigations on QED and parity non-conservation effects.
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| 7. |
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| 8. |
- Li, Jiguang, et al.
(author)
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Hyperfine induced transitions in He-like, Be-like and Mg-like ions
- 2009
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In: Journal of Physics, Conference Series. - : Bibliopolis, Edizioni di Filosofia e Scienze. - 1742-6588 .- 1742-6596. ; 194:15
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Journal article (peer-reviewed)abstract
- Hyperfine quenching rates for 1s2s 1S0 → 1s2 1S0 M1 transition of He-like ions, 2s2p 3P0 → 3P2 → 2s2 1S0 E1 transition of Be-like ions and 3s3p 3P0 → 3s2 S0 E1 transition of Mg-like ions have been calculated from relativistic configuration interaction wavefunctions including the frequency independent Breit interaction and QED effects. The present study not only supply accurate theoretical values for developing atomic clocks, diagnosing low-density plasma, probing nuclear properties, exploring weak interaction beyond standard model, but also to analyze some characteristics in hyperfine induced transitions.
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| 9. |
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| 10. |
- Li, Yan, et al.
(author)
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Is blood pressure during the night more predictive of cardiovascular outcome than during the day?
- 2008
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In: Blood Pressure Monitoring. - 1359-5237 .- 1473-5725. ; 13:3, s. 145-147
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Journal article (peer-reviewed)abstract
- The objective of this study was to investigate the prognostic significance of the ambulatory blood pressure (BP) during night and day and of the night-to-day BP ratio (NDR). We studied 7458 participants (mean age 56.8 years; 45.8% women) enrolled in the International Database on Ambulatory BP in relation to Cardiovascular Outcome. Using Cox models, we calculated hazard ratios (HR) adjusted for cohort and cardiovascular risk factors. Over 9.6 years (median), 983 deaths and 943 cardiovascular events occurred. Nighttime BP predicted mortality outcomes (HR, 1.18-1.24; P<0.01) independent of daytime BP. Conversely, daytime systolic (HR, 0.84; P<0.01) and diastolic BP (HR, 0.88; P<0.05) predicted only noncardiovascular mortality after adjustment for nighttime BR Both daytime BP and nighttime BP consistently predicted all cardiovascular events (HR, 1.11-1.33, P<0.05) and stroke (HR, 1.21-1.47; P<0.01). Daytime BP lost its prognostic significance for cardiovascular events in patients on antihypertensive treatment. Adjusted for the 24-h BP, NDR predicted mortality (P<0.05), but not fatal combined with nonfatal events. Participants with systolic NDR of at least 1 compared with participants with normal NDR (>= 0.80 to < 0.90) were older, at higher risk of death, but died at higher age. The predictive accuracy of the daytime and nighttime BP and the NDR depended on the disease outcome under study. The increased mortality in patients with higher NDR probably indicates reverse causality. Our findings support recording the ambulatory BP during the whole day.
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