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Search: WFRF:(Li YJ) > (2000-2004)

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1.
  • Liu, YJ, et al. (author)
  • Modulation of early immune responses and suppression of Trypanosoma brucei brucei infections by surgical denervation of the spleen
  • 2000
  • In: Neuroimmunomodulation. - : S. Karger AG. - 1021-7401 .- 1423-0216. ; 8:1, s. 31-38
  • Journal article (peer-reviewed)abstract
    • <i>Objective:</i> To examine critical interactions between the nervous system and the immune system during experimental African trypanosomiasis. <i>Methods and Results:</i> Inoculation of <i>Trypanosoma brucei brucei </i>resulted in early interferon (IFN)-γ production, elevated corticosterone and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) levels and increased splenocyte proliferation, as measured by enzyme-linked immunospot assay, radioimmunoassay and thymidine incorporation assay, respectively. Splenic denervation suppressed IFN-γ, corticosterone and PGE<sub>2</sub> production, enhanced splenocyte proliferation, and significantly reduced parasitemia and prolonged rat survival. <i>Conclusions:</i> Our data show substantial effects of the nervous system on early immune responses that may influence the outcome of this disease. These effects were not dependent on cytokine inhibitory mediators such as prostaglandins or stress hormones. More investigations are required to understand the evident neural control over the immune system during infectious challenges, which may assist in novel therapeutic approaches.
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2.
  • Liu, YJ, et al. (author)
  • Splenic denervation suppresses mRNA gene expression and protein production of IL-1beta and IL-6 by peritoneal macrophages in both Trypanosoma brucei brucei-infected and non-infected rats
  • 2004
  • In: Neuroimmunomodulation. - : S. Karger AG. - 1021-7401 .- 1423-0216. ; 11:2, s. 113-118
  • Journal article (peer-reviewed)abstract
    • <i>Objective:</i> To test the hypothesis that the nervous system participates in modulating the immune response during experimental African trypanosomiasis caused by <i>Trypanosoma brucei brucei</i>. <i>Methods and Results:</i> Using in situ hybridization and immunochemistry, we studied the effects of splenic sympathectomy on mRNA gene expression and protein production of IL-1β and IL-6 in splenic and peritoneal macrophages (PMΦ) of Sprague-Dawley rats infected with <i>T. brucei brucei</i> and non-infected rats. The enhancements of mRNA gene expression and production of IL-1β and IL-6 by peritoneal macrophages were significantly suppressed by the splenic sympathectomy in both infected and non-infected rats. <i>Conclusions:</i> Our data indicate a probably stimulatory role of the sympathetic nervous system during the host immune response in both normal and <i>T. brucei brucei</i>-infected rats.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Bakhiet, M (2)
Liu, YJ (2)
Mustafa, M (1)
Mustafa, A. (1)
Li, HL (1)
Ozenci, V (1)
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Cui, JG (1)
Li, ZL (1)
Nuortio, L (1)
Svaren-Quiding, C (1)
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University
Karolinska Institutet (2)
Language
English (2)

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