1. |
- Choularton, T. W., et al.
(author)
-
The Great Dun Fell Cloud Experiment 1993 : An overview
- 1997
-
In: Atmospheric Environment. - 1352-2310. ; 31:16, s. 2393-2405
-
Journal article (peer-reviewed)abstract
- The 1993 Ground-based Cloud Experiment on Great Dun Fell used a wide range of measurements of trace gases, aerosol particles and cloud droplets at five sites to study their sources and sinks especially those in cloud. These measurements have been interpreted using a variety of models. The conclusions add to our knowledge of air pollution, acidification of the atmosphere and the ground, eutrophication and climate change. The experiment is designed to use the hill cap cloud as a flow-through reactor, and was conducted in varying levels of pollution typical of much of the rural temperate continental northern hemisphere in spring-time.
|
|
2. |
|
|
3. |
|
|
4. |
- ENGMAN, L, et al.
(author)
-
OXYGEN-ATOM TRANSFER FROM ALKYLPEROXYL RADICALS TO AROMATIC TELLURIDES
- 1995
-
In: ORGANOMETALLICS. - : AMER CHEMICAL SOC. ; 14:8
-
Other publication (other academic/artistic)abstract
- The reactions of alkylperoxyl radicals with the diaryl tellurides bis(4-aminophenyl) telluride and bis(4-hydroxyphenyl) telluride were studied by pulse- and gamma-radiolysis techniques in aqueous media. The diaryl tellurides served predominantly (similar
|
|
5. |
|
|
6. |
- Lind, U., et al.
(author)
-
Valine 571 functions as a regional organizer in programming the glucocorticoid receptor for differential binding of glucocorticoids and mineralocorticoids
- 1999
-
In: Journal of Biological Chemistry. - : Elsevier BV. - 0021-9258 .- 1083-351X. ; 274:26, s. 18515-18523
-
Journal article (peer-reviewed)abstract
- The glucocorticoid receptor (GR) interacts specifically with glucocorticoids, whereas its closest relative, the mineralocorticoid receptor (MR), interacts with both glucocorticoids and mineralocorticoids, such as aldosterone. To investigate the mechanism underlying the glucocorticoid/mineralocorticoid specificity of the GR, we used a yeast model system to screen for GR ligand-binding domain mutants, substituted with MR residues in the segment 565-574, that can be efficiently activated by aldosterone. In all such increased activity mutants, valine 571 was replaced by methionine, even though most mutants also contained substitutions of other residues with their MR counterparts. Further analysis in yeast and COS-7 cells has revealed that the identity of residue 571 determines the behavior of other MR substituted residues in the 565-574 segment. Generally, MR substitutions in this region are only consistent with aldosterone binding if residue 571 is also replaced with methionine (MR conformation). If residue 571 is valine (GR conformation), most other MR substitution mutants drastically reduce interaction with both mineralocorticoid and glucocorticoid hormones. Based on these functional data, we hypothesize that residue 571 functions as a regional organizer involved in discriminating between glucocorticoid and mineralocorticoid hormones. We have used a molecular model of the GR ligand-binding domain in an attempt to interpret our functional data in structural terms.
|
|
7. |
|
|
8. |
|
|
9. |
|
|
10. |
|
|