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- Lawler, M., et al.
(author)
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The European Cancer Patient's Bill of Rights, update and implementation 2016
- 2016
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In: Esmo Open. - : Elsevier BV. - 2059-7029. ; 1:6
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Journal article (peer-reviewed)abstract
- In this implementation phase of the European Cancer Patient's Bill of Rights (BoR), we confirm the following three patient-centred principles that underpin this initiative: 1. The right of every European citizen to receive the most accurate information and to be proactively involved in his/her care. 2. The right of every European citizen to optimal and timely access to a diagnosis and to appropriate specialised care, underpinned by research and innovation. 3. The right of every European citizen to receive care in health systems that ensure the best possible cancer prevention, the earliest possible diagnosis of their cancer, improved outcomes, patient rehabilitation, best quality of life and affordable health care. Agree our high-level goal. The vision of 70% longterm survival for patients with cancer in 2035, promoting cancer prevention and cancer control and the associated progress in ensuring good patient experience and quality of life. Establish the major mechanisms to underpin its delivery. (1) The systematic and rigorous sharing of best practice between and across European cancer healthcare systems and (2) the active promotion of Research and Innovation focused on improving outcomes; (3) Improving access to new and established cancer care by sharing best practice in the development, approval, procurement and reimbursement of cancer diagnostic tests and treatments. Work with other organisations to bring into being a Europe based centre that will (1) systematically identify, evaluate and validate and disseminate best practice in cancer management for the different countries and regions and (2) promote Research and Innovation and its translation to maximise its impact to improve outcomes.
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- Bigdeli, Sedigheh, et al.
(author)
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An insight into using DFT data for Calphad modeling of solid phases in the third generation of Calphad databases, a case study for Al
- 2019
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In: Calphad. - : Elsevier. - 0364-5916 .- 1873-2984. ; 65, s. 79-85
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Journal article (peer-reviewed)abstract
- In developing the next generation of Calphad databases, new models are used in which each term contributing to the Gibbs energy has a physical meaning. To continue the development, finite temperature density-functional-theory (DFT) results are used in the present work to discuss and suggest the most applicable and physically based model for Calphad assessments of solid phases above the melting point (the breakpoint for modeling the solid phase in previous assessments). These results are applied to investigate the properties of a solid in the superheated temperature region and to replace the melting temperature as the breakpoint with a more physically based temperature, i.e., where the superheated solid collapses into the liquid. The advantages and limitations of such an approach are presented in terms of a new assessment for unary aluminum.
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| 5. |
- Fredholm, Simon, et al.
(author)
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SATB1 in Malignant T Cells
- 2018
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In: Journal of Investigative Dermatology. - : Elsevier. - 0022-202X .- 1523-1747. ; 138:8, s. 1805-1815
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Journal article (peer-reviewed)abstract
- Deficient expression of SATB1 hampers thymocyte development and results in inept T-cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides, the most frequent variant of cutaneous T-cell lymphoma. Here, we report on a disease stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. STAT5 inhibited SATB1 expression through induction of microRNA-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32), whereas increased SATB1 expression had the opposite effect, indicating that the microRNA-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. In accordance, inhibition of STAT5 and its upstream activator JAK3 triggered increased SATB1 expression and a concomitant suppression of IL-5 and IL-9 expression in malignant T cells. In conclusion, we provide a mechanistic link between the proto-oncogenic JAK3/STAT5/microRNA-155 pathway, SATB1, and cytokines linked to CTCL severity and progression, indicating that SATB1 dysregulation is involved in cutaneous T-cell lymphoma pathogenesis.
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- Hallstedt, B., et al.
(author)
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PrecHiMn-4—A thermodynamic database for high-Mn steels
- 2017
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In: Calphad. - : Elsevier. - 0364-5916 .- 1873-2984. ; 56, s. 49-57
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Journal article (peer-reviewed)abstract
- This paper concerns a Calphad database that was developed to describe precipitation of cubic carbides and nitrides (V, Nb and Ti) in high manganese steels and to describe phase equilibria in high manganese steels with high aluminium content. The database has also been shown to be useful for calculations on medium manganese steels and low-density steels with varying aluminium additions. Thus the database covers a significant fraction of the steels that are termed advanced high strength steels (AHSS) of the second and third generation. A number of systems were assessed (or reassessed) for the database, namely Fe–Mn–Al, Fe–Mn–C, Fe–Nb, Mn–Nb, Fe–Mn–Nb, Fe–Nb–V, Fe–Nb–C, Mn–Nb–C, Fe–Mn–Nb–C, Nb–N, Fe–Mn–Nb–N. The remaining systems were taken from published assessments. The database covers the elements Fe, Mn, Al, Si, V, Nb, Ti, C and N.
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| 7. |
- Lindahl, B. Ingemar B., et al.
(author)
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Consciousness and Neural Force Fields
- 2016
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In: Journal of consciousness studies. - 1355-8250 .- 2051-2201. ; 23:7-8, s. 228-253
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Journal article (peer-reviewed)abstract
- This article compares Wolfgang Kohler's pioneering field theory of the consciousness brain relation with Benjamin Libet's conscious mental field theory and Karl Popper's mental force field hypothesis. In the discussion of Kohler's theory we devote special attention to his analysis of problems of sense perception and to his explanation of figural after-effects. Both Libet and Popper take consciousness to causally interact with the brain, and we argue that even Kohler presupposes an interactionist interpretation of the consciousness brain relation. We argue that nothing necessarily rules out that consciousness as something subjective may causally interact with the brain as something objective. We discuss an evolutionary argument for the theory that consciousness causally interacts with the brain, and we consider some arguments for consciousness having had a survival value.
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| 8. |
- Lindahl, B. Ingemar B., et al.
(author)
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Motor Control and the Causal Relevance of Conscious Will : Libet's Mind–Brain Theory
- 2019
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In: Journal of Theoretical and Philosphical Psychology. - : American Psychological Association (APA). - 1068-8471 .- 2151-3341. ; 39:1, s. 46-59
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Journal article (peer-reviewed)abstract
- This article examines three aspects of the problem of understanding Benjamin Libet's idea of conscious will causally interacting with certain neural activities involved in generating overt bodily movements. The first is to grasp the notion of cause involved, and we suggest a definition. The second is to form an idea of by what neural structure(s) and mechanism(s) a conscious will may control the motor activation. We discuss the possibility that the acts of control have to do with levels of supplementary motor area activity and with the activation of populations of excitatory and inhibitory interneurons. The third aspect is to conceive of the main features of Libet's proposed conscious mental field (CMF). We consider both an ontological and an epistemological interpretation of the CMF being nonphysical. In an attempt to refute the idea that Libet's dualist mind–brain interactionism would violate the law of conservation of energy, we suggest that a CMF may alter the probability of the ion-channel gating by influencing structures of a size to which quantum mechanics needs to he applied. We argue that given the suggested definition of cause, and given the epistemological interpretation of the CMF being nonphysical, nothing would necessarily rule out that an element of a CMF, conscious will, may causally interact with neural activities in the brain. This defense of the idea of conscious will being causally efficacious has a hearing not only on the understanding of the mind–brain relation but also on the free will debate.
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| 10. |
- Olausson, Sepideh, 1972, et al.
(author)
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The Meaning of Comfort in the Intensive Care Unit
- 2019
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In: Critical Care Nursing Quarterly. - 0887-9303. ; 42:3, s. 329-341
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Journal article (peer-reviewed)abstract
- Providing comfort in an intensive care unit (ICU) setting is often related to pain relief and end-of-life care; environmental factors are often neglected, despite the major role of the environment on the patients' well-being and comfort. The aim of this article was to explore the meanings of comfort from a theoretical and empirical perspective to increase the understanding of what comfort means in ICU settings. A lexical analysis and serials of workshops were performed, and data were analyzed using a qualitative content analysis. The findings from the theoretical analysis show that comfort has a broad range of synonyms related to both subjective experiences and objective and physical qualities. The findings from the empirical part reveal 4 themes: comfort in relation to nature, comfort in relation to situation and people, comfort in relation to place, and comfort in relation to objects and material. Materiality, functionality, memory, culture, and history stipulate comfort. It is challenging to discern what comfort is when it comes to function and emotions. We also found that comfort is closely linked to nature and well-being. © 2019 Wolters Kluwer Health, Inc. All rights reserved.
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