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Search: WFRF:(Liu Zhengwei) > (2023)

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  • Liu, Hua, et al. (author)
  • Advance in oral delivery of living material
  • 2023
  • In: Biomedical Technology. - : Elsevier BV. - 2949-723X. ; 3, s. 26-39
  • Research review (peer-reviewed)abstract
    • Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from bench to bedside. However, precise delivery and continuous maintenance of cell viability and activity to acquire stable and ideal therapeutic efficacy remain challenging. Living material is the smart integration of the flexibly programmable functionality of biomaterial and the autonomous environmental responsiveness of living elements, heralding a new era of biotherapeutics in addressing human health concerns. Here, our review aims at presenting an overview of the status of the oral delivery of living material from a biological, technical, and practical perspective, describing the clinical significance and potential, the current technological development and dilemma, as well as the prospect.
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3.
  • Wang, Yukun, et al. (author)
  • Simulation study of the purification system for indoor oil mist control in machining factories
  • 2023
  • In: Building Simulation. - : Springer Nature. - 1996-3599 .- 1996-8744. ; 16:8, s. 1361-1374
  • Journal article (peer-reviewed)abstract
    • High-concentration oil mists can cause serious health problems to workers, which are generally mitigated by ventilation and purification systems. However, the coupling relationship between these systems is not clear. In this study, the effects of purifier outlet direction, purification air volume, installation height, and purification efficiency on indoor oil mist distribution were investigated by numerical simulation using an actual machining factory. The mitigation of oil mist in various combinations of ventilation and purification systems was also discussed. The results show that the outlet direction of the purifier has a great influence on the distribution of oil mist in the factory, and the maximum difference of oil mist concentration in the breathing zone under different orientations is 17%. The best purifier outlet direction is vertically upward. When the purifier outlet direction is upward, a larger purification air volume is beneficial for contaminant removal, and a lower purifier exhaust installation height is helpful for oil mist discharge from the bottom of the factory and reducing the concentration of oil mist in the breathing area. The oil mist concentration of purifier exhaust increases from 0 to 2 mg/m3 and the oil mist concentration in the breathing zone increases by 67%. The combined system of purification system with the roof exhaust system and displacement ventilation system has the optimal pollution removal efficiency and the lowest concentration of oil mist in the breathing zone compared to other systems. The research results can provide a reference for the design, installation, and operation of ventilation and purification systems in machining factories.
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