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- Tobias, Deirdre K, et al.
(author)
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Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
- 2023
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In: Nature Medicine. - 1546-170X. ; 29:10, s. 2438-2457
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Research review (peer-reviewed)abstract
- Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
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3. |
- Gander, Pierre, 1971, et al.
(author)
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A framework for memory of fictional information
- 2022
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In: Poster presented at the Psychonomic Society's 63rd Annual Meeting, Boston, Massachusetts, USA, Nov. 17–20, 2022..
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Conference paper (other academic/artistic)
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4. |
- Gander, Pierre, 1971, et al.
(author)
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A social differential outcomes learning task: Performance, EEG, and questionnaire data
- 2020
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In: Data in Brief. - : Elsevier BV. - 2352-3409. ; 33
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Journal article (peer-reviewed)abstract
- This article contains performance data, questionnaire ratings, and EEG data from a differential outcomes learning task from two experiments. In both experiments, the standard differential outcomes learning task was extended to involve a social dimension, in order to capture how people can learn from others by observation. In Experiment 1 (N=20), using a within-subjects design, participants learned pairings of image stimuli in four conditions: 1) individual-differential outcomes, 2) individual-non-differential outcomes, 3) social-differential outcomes, and 4) social-non-differential outcomes. The social condition had a screen-captured video recording of the outcomes (but not the actions themselves) of another person performing the task. During the task, the performance of the participants was measured. After the task, participants rated their experience in a questionnaire. The procedure for Experiment 2 (N=33) was similar to Experiment 1, but with a stronger social manipulation using a video of another person's face showing facial expressions reflecting the outcomes. In addition, EEG was measured while performing the task. For more insight, please see Vicarious value learning: Knowledge transfer through affective processing on a social differential outcomes task (Rittmo et al., 2020).
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5. |
- Gander, Pierre, 1971, et al.
(author)
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Differences in experienced memory qualities between factual and fictional events
- 2023
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In: Journal of Cognition and Culture. - 1567-7095. ; 23:3–4, s. 378-396
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Journal article (peer-reviewed)abstract
- The experienced qualities of memories of factual and fictional events have been little researched previously. The few studies that exist find no or few differences. However, one reason to expect differences in memory qualities is that processing of fact and fiction seem to involve activation of different brain areas. The present study expands earlier research by including a wider range of memory qualities, using positive and negative events, and three time-points: immediately after, after a ten-minute delay and after a five-week delay. Participants (N = 52) read four short stories in English, labelled either fact or fiction, and rated memory qualities on 7-point scales. Results show no differences; however, an interaction was found between fictionality and story emotional valence, in that memories of negative fictional stories are rated as more clear. The higher clarity can be explained by previous findings that negative events from stories are in general remembered in more detail, in combination with the idea that fiction entails simulation to a higher degree than fact. The conclusion is that although a difference in memory qualities between fact and fiction was found in one case, memory qualities seem not to play an operative role when the memory system distinguishes fact from fiction.
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6. |
- Gander, Pierre, 1971, et al.
(author)
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Memory of Fictional Information: A Theoretical Framework
- 2023
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In: Perspectives on Psychological Science. - 1745-6916 .- 1745-6924.
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Journal article (peer-reviewed)abstract
- Much of the information people encounter in everyday life is not factual; it originates from fictional sources, such as movies, novels, and video games, and from direct experience such as pretense, role-playing, and everyday conversation. Despite the recent increase in research on fiction, there is no theoretical account of how memory of fictional information is related to other types of memory or of which mechanisms allow people to separate fact and fiction in memory. We present a theoretical framework that places memory of fiction in relation to other cognitive phenomena as a distinct construct and argue that it is an essential component for any general theory of human memory. We show how fictionality can be integrated in an existing memory model by extending Rubin’s dimensional conceptual memory model. By this means, our model can account for explicit and implicit memory of fictional information of events, places, characters, and objects. Further, we propose a set of mechanisms involving various degrees of complexity and levels of conscious processing that mostly keep fact and fiction separated but also allow information from fiction to influence real-world attitudes and beliefs: content-based reasoning, source monitoring, and an associative link from the memory to the concept of fiction.
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7. |
- Gander, Pierre, 1971, et al.
(author)
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What kind of memory is memory of fiction?
- 2022
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In: Presented at the Annual Meeting of the Swedish Cognitive Science Society.
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Conference paper (other academic/artistic)
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8. |
- Lowe, Robert
(author)
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Habit-Based and Goal-Directed Systems: Knowledge Transfer in Individual and Social Learning
- 2020
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In: Studies in Applied Philosophy, Epistemology and Rational Ethics book series (SAPERE, volume 52). - : Springer. ; , s. 153-167
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Book chapter (peer-reviewed)abstract
- The present chapter discusses value-based habitual and goal-directed systems as studied in the animal and human learning literature. It focuses on the means by which these two systems might interact in knowledge transfer, particularly as it applies to social learning. Knowledge is conceived here in terms of types of logic computations as implemented by neural networks. A discussion of dual-process type structures in the brain is provided as well as neural-dynamic implementations thereof and considerations for how a perspective of the brain as carrying out logic computations might be useful for developing the general cognitive capacities of artificial agents.
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9. |
- Lowe, Robert, et al.
(author)
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Vicarious value learning by differential outcomes training: A social transfer of control methodology
- 2021
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In: MethodsX. - : Elsevier BV. - 2215-0161. ; 8
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Journal article (peer-reviewed)abstract
- This article adapts an existing experimental protocol for assessing individuals’ ability to transfer knowledge across instrumental and pavlovian learning stages. The protocol (Transfer of Control using differential outcomes learning) is adapted to fit social contexts wherein the pavlovian learning phase is modulated so that individuals are able to observe, and potentially learn from, the stimulus associated with reinforcing outcomes presented to another (observable) individual. Transfer of Control concerns participants combining knowledge of learned instrumental and pavlovian (stimulus, response, outcome) associations in order to ground the learning of new associations. The article describes the theoretical and procedural underpinnings of a novel Social Transfer of Control methodology. The use of such a methodology is two-fold: i) to serve as a guide to researchers interested in evaluating how individuals can learn from others in a partially observable setting, i.e. when behavioural and reinforcing outcome information is hidden, and bring to bear this knowledge on their own instrumental decision making; ii), to facilitate investigation of the routes of cognitive and emotional empathy, with potential applications for educational and clinical settings. • Three stage Transfer of Control behavioural methodology is adapted to include a social (pavlovian) learning stage. • Hypotheses can be tested that concern learning rewarding instrumental responses achieved by observation of others’ emotionally expressive reactions to differentially rewarding outcomes. • Methodological and validation considerations for evaluating the above are presented
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10. |
- Markelius, Alva, et al.
(author)
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Differential Outcomes Training of Visuospatial Memory: A Gamified Approach Using a Socially Assistive Robot
- 2024
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In: INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS. - : Springer Science and Business Media B.V.. - 1875-4791 .- 1875-4805. ; 16:2, s. 363-384
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Journal article (peer-reviewed)abstract
- This study represents the first stage of evaluating whether cognitive training interventions may be facilitated by the presence of a socially assistive robot (SAR) and gamification. Our experimental setup involves using a SAR providing feedback to a gamified visuospatial working memory task, administered according to a differential outcomes training (DOT) protocol. The study's main objective was to investigate whether performance and attitude towards the task would be affected by different robotic setups (none, simulated or physical) and in relation to different challenge levels. We measured performance accuracy on the gamified visuospatial memory task and self-reported affective ratings, which are relevant for assessing attitude towards the task and providing indicators to the potential for using a SAR for a longer-term cognitive intervention. Additionally, we conducted exploratory analyses of eye movement strategies for memory encoding during the task. The results demonstrated a significant differential outcomes effect (DOE) on memory performance accuracy, regardless of Robot type and Challenge level, providing evidence that a DOE can still be obtained when a SAR interacts with participants. Moreover, the results from the affective ratings revealed that participants accompanied by the physical robot reported lower levels of stress and increased levels of control. Our results demonstrate, for the first time, a DOE using a SAR in a gamified context. This result, coupled with positive subjective reporting of the human-robot interactive experience of participants, demonstrates the potential for using a SAR to: (i) promote positive attitudes for a DOT-based cognitive intervention, without (ii) negatively affecting task performance.
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