| 1. |
- Clark, Andrew G., et al.
(författare)
-
Evolution of genes and genomes on the Drosophila phylogeny
- 2007
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
-
Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
|
|
| 2. |
- Baumjohann, W., et al.
(författare)
-
Dynamics of thin current sheets : Cluster observations
- 2007
-
Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 25:6, s. 1365-1389
-
Forskningsöversikt (refereegranskat)abstract
- The paper tries to sort out the specific signatures of the Near Earth Neutral Line (NENL) and the Current Disruption (CD) models. and looks for these signatures in Cluster data from two events. For both events transient magnetic si-natures are observed, together with fast ion flows. In the simplest form of NENL scenario, with a large-scale two-dimensional reconnection site, quasi-invariance along Y is expected. Thus the magnetic signatures in the S/C frame are interpreted as relative motions, along the X or Z direction, of a quasi-steady X-line, with respect to the S/C. In the simplest form of CD scenario an azimuthal modulation is expected. Hence the signatures in the S/C frame are interpreted as signatures of azimuthally (along Y) moving current system associated with low frequency fluctuations of J(y) and the corresponding field-aligned currents Event I covers a pseudo-breakup, developing only at high latitudes. First, a thin (H approximate to 2000Km approximate to 2 rho(i), with pi the ion gyroradius) Current Sheet (CS) is found to be quiet. A slightly thinner CS (H approximate to 1000-2000 km approximate to 1-2 rho(i)), crossed about 30 min later, is found to be active. with fast earthward ion flow bursts (300-600 km/s) and simultaneous large amplitude fluctuations (delta B/B similar to 1). In the quiet CS the current density J(y) is carried by ions. Conversely, in the active CS ions are moving eastward; the westward current is carried by electrons that move eastward, faster than ions. Similarly, the velocity of earthward flows (300-600 km/s), observed during the active period. maximizes near or at the CS center. During the active phase of Event I no signature of the crossing of an X-line is identified, but an X-line located beyond Cluster could account for the observed ion flows, provided that it is active for at least 20 min. Ion flow bursts can also be due to CD and to the corresponding dipolarizations which are associated with changes in the current density. Yet their durations are shorter than the duration of the active period. While the overall partial derivative Bz/partial derivative t is too weak to accelerate ions up to the observed velocities, short duration partial derivative B-z/partial derivative t can produce the azimuthal electric field requested to account for the observed ion flow bursts. The corresponding large amplitude perturbations are shown to move eastward. which suggests that the reduction in the tail current could be achieved via a series of eastward traveling partial dipolarisations/CD. The second event is much more active than the first one. The observed flapping of the CS corresponds to an azimuthally propagating wave. A reversal in the proton flow velocity, from 1000 to + 1000 km/s, is measured by CODIF. The overall flow reversal, the associated change in the sign of B-z and the relationship between B-x and B-y suggest that the spacecraft are moving with respect to an X-line and its associated Hall-structure. Yet, a simple tailward retreat of a large-scale X-line cannot account for all the observations, since several flow reversals are observed. These quasi-periodic flow reversals can also be associated with an azimuthal motion of the low frequency oscillations. Indeed, at the beginning of the interval B-y varies rapidly along the Y direction; the magnetic signature is three-dimensional and essentially corresponds to a structure of filamentary field-aligned current, moving eastward at similar to 200 km/s. The transverse size of the structure is similar to 1000 km. Similar structures are observed before and after. Thesefilamentary structures are consistent with an eastward propagation of an azimuthal modulation associated with a current system J(y), J(x). During Event 1, signatures of filamentary field-aligned current structures are also observed, in association with modulations of J(y). Hence, for both events the structure of the magnetic fields and currents is three-dimensional.
|
|
| 3. |
- Finkielstain, GP, et al.
(författare)
-
An extensive genetic program occurring during postnatal growth in multiple tissues
- 2009
-
Ingår i: Endocrinology. - : The Endocrine Society. - 1945-7170 .- 0013-7227. ; 150:4, s. 1791-1800
-
Tidskriftsartikel (refereegranskat)abstract
- Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified more than 1600 genes that were regulated with age (1 vs. 4 wk) coordinately in kidney, lung, and heart of male mice, including many genes that regulate proliferation. As examples, we focused on three growth-promoting genes, Igf2, Mest, and Peg3, that were markedly down-regulated with age. In situ hybridization revealed that expression occurred in organ-specific parenchymal cells and suggested that the decreasing expression with age was due primarily to decreased expression per cell rather than a decreased number of expressing cells. The declining expression of these genes was slowed during hypothyroidism and growth inhibition (induced by propylthiouracil at 0–5 wk of age) in male rats, suggesting that the normal decline in expression is driven by growth rather than by age per se. We conclude that there exists an extensive genetic program occurring during postnatal life. Many of the involved genes are regulated coordinately in multiple organs, including many genes that regulate cell proliferation. At least some of these are themselves apparently regulated by growth, suggesting that, in the embryo, a gene expression pattern is established that allows for rapid somatic growth of multiple tissues, but then, during postnatal life, this growth leads to negative-feedback changes in gene expression that in turn slow and eventually halt somatic growth, thus imposing a fundamental limit on adult body size.
|
|
| 4. |
|
|
| 5. |
- Lindblad-Toh, Kerstin, et al.
(författare)
-
Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
-
Tidskriftsartikel (refereegranskat)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
|
|
| 6. |
|
|
