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Träfflista för sökning "WFRF:(Lundkvist L) srt2:(2000-2004)"

Search: WFRF:(Lundkvist L) > (2000-2004)

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1.	Padyukov, L, et al. (author) Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis. 2003 In: Ann Rheum Dis. - : BMJ. - 0003-4967. ; 62:6, s. 526-9 Journal article (peer-reviewed)
2.	Andersson, I., et al. (author) Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus 2004 In: Journal of Virology. - 0022-538X .- 1098-5514. ; 78:8, s. 4323-4329 Journal article (peer-reviewed)abstract Crimean-Congo hemorrhagic fever virus (CCHFV) belongs to the genus Nairovirus within the family Bunyaviridae and is the causative agent of severe hemorrhagic fever. Despite increasing knowledge about hemorrhagic fever viruses, the factors determining their pathogenicity are still poorly understood. The interferon-induced MxA protein has been shown to have an inhibitory effect on several members of the Bunyaviridae family, but the effect of MxA against CCHFV has not previously been studied. Here, we report that human MxA has antiviral activity against CCHFV. The yield of progeny virus in cells constitutively expressing MxA was reduced up to 1,000-fold compared with control cells, and accumulation of viral genomes was blocked. Confocal microscopy revealed that MxA colocalizes with the nucleocapsid protein (NP) of CCHFV in the perinuclear regions of infected cells. Furthermore, we found that MxA interacted with NP by using a coimmunoprecipitation assay. We also found that an amino acid substitution (E645R) within the C-terminal domain of MxA resulted in a loss of MxA antiviral activity and, concomitantly, in the capacity to interact with CCHFV NP. These results suggest that MxA, by interacting with a component of the nucleocapsid, prevents replication of CCHFV viral RNA and thereby inhibits the production of new infectious virus particles.
3.	Bergman, A, et al. (author) APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations 2003 In: Experimental cell research. - : Elsevier BV. - 0014-4827. ; 287, s. 1- Journal article (peer-reviewed)
4.	Bergman, A, et al. (author) Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin 2004 In: The Journal of biological chemistry. - 0021-9258. ; 279, s. 16744- Journal article (peer-reviewed)
5.	Bucht, G, et al. (author) Modifying the cellular transport of DNA-based vaccines alters the immune response to hantavirus nucleocapsid protein 2001 In: Vaccine. - : Elsevier BV. - 0264-410X. ; 19:28-29, s. 3820-3829 Journal article (peer-reviewed)
6.	Escutenaire, S, et al. (author) Spatial and temporal dynamics of Puumala hantavirus infection in red bank vole (Clethrionomys glareolus) populations in Belgium 2000 In: Virus research. - 0168-1702. ; 67:1, s. 91-107 Journal article (peer-reviewed)
7.	Haglund, M, et al. (author) Characterisation of human tick-borne encephalitis virus from Sweden 2003 In: Journal of medical virology. - : Wiley. - 0146-6615. ; 71:4, s. 610-621 Journal article (peer-reviewed)
8.	Hall, H, et al. (author) Autoradiographic localization of 5-HT(2A) receptors in the human brain using [(3)H]M100907 and [(11)C]M100907 2000 In: Synapse (New York, N.Y.). - 0887-4476. ; 38:4, s. 421-431 Journal article (peer-reviewed)
9.	Halldin, C, et al. (author) [(11)C]PE2I: a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain 2003 In: European journal of nuclear medicine and molecular imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 30:9, s. 1220-1230 Journal article (peer-reviewed)
10.	Jin, Y, et al. (author) Interferon-gamma mediates neuronal killing of intracellular bacteria 2004 In: Scandinavian journal of immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 60:5, s. 437-448 Journal article (peer-reviewed)

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Result 1-10 of 21

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Type of publication: journal article (18); conference paper (3)

Type of content: peer-reviewed (17); other academic/artistic (4)

Author/Editor: Lundkvist, A (7); Lindquist, L (3); Halldin, C (2); Permert, J (2); Farde, L (2); Lannfelt, L (2); show more...; Olsson, H. (1); Vaheri, A (1); KLARESKOG, L (1); Jonsson, L. (1); Winblad, B (1); Berne, C (1); Johansson, B (1); OSTENSON, CG (1); Jin, Y. (1); Mirazimi, A (1); Lendahl, U (1); Andersson, P (1); Pfeffer, M. (1); Eklund, Anders (1); Avsic-Zupanc, T (1); Klingstrom, J (1); Padyukov, L (1); Malm, J (1); Lampa, J (1); Andersson, I (1); Forsgren, M (1); Mattsson, J. (1); Ringden, O (1); Hall, H (1); Sedvall, G (1); Johnell, O. (1); Barkholt, L (1); Hentschke, P (1); Lundkvist, G (1); Rottenberg, ME (1); Isaksson, B (1); Arnelo, U (1); Ernestam, S (1); Magnusson, Karl-Eric (1); Fagerlund, M (1); Vapalahti, O. (1); Eriksson, S. (1); Mousavi-Jazi, M (1); Cederholm, T (1); Karlsson, P (1); Heimburger, M (1); Kristensson, K (1); Lundkvist, Elisabeth (1); Malm, Jan (1); show less...

University: Karolinska Institutet (16); Uppsala University (4); Umeå University (2); Linköping University (2)

Language: English (21)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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