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- Denison, H, et al.
(author)
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Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects : a randomized clinical trial
- 2014
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In: Diabetes, obesity and metabolism. - : Wiley. - 1462-8902 .- 1463-1326. ; 16:4, s. 334-343
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Journal article (peer-reviewed)abstract
- AIM:Inhibition of diacylglycerol acyltransferase 1 (DGAT1) is a potential treatment modality for patients with type 2 diabetes mellitus and obesity, based on preclinical data suggesting it is associated with insulin sensitization and weight loss. This randomized, placebo-controlled, phase 1 study in 62 overweight men explored the effects and tolerability of AZD7687, a reversible and selective DGAT1 inhibitor.METHODS:Multiple doses of AZD7687 (1, 2.5, 5, 10 and 20 mg/day, n = 6 or n = 12 for each) or placebo (n = 20) were administered for 1 week. Postprandial serum triacylglycerol (TAG) was measured for 8 hours after a standardized 45% fat meal. Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) were measured and a paracetamol challenge was performed to assess gastric emptying.RESULTS:Dose-dependent reductions in postprandial serum TAG were demonstrated with AZD7687 doses ≥5 mg compared with placebo (p < 0.01). Significant (p < 0.001) increases in plasma GLP-1 and PYY levels were seen at these doses, but no clear effect on gastric emptying was demonstrated at end of treatment. With AZD7687doses >5 mg/day, gastrointestinal (GI) side effects increased; 11/18 of these participants discontinued treatment owing to diarrhoea.CONCLUSIONS:Altered lipid handling and hormone secretion in the gut were demonstrated during 1-week treatment with the DGAT1 inhibitor AZD7687. However, the apparent lack of therapeutic window owing to GI side effects of AZD7687, particularly diarrhoea, makes the utility of DGAT1 inhibition as a novel treatment for diabetes and obesity questionable.
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| 4. |
- Mayorca, María A., et al.
(author)
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A New Reduced Order Modeling for Stability and Forced Response Analysis of Aero-Coupled Blades Considering Various Mode Families
- 2012
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In: Journal of turbomachinery. - : ASME International. - 0889-504X .- 1528-8900. ; 134:5, s. 051008-
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Journal article (peer-reviewed)abstract
- This paper presents the description and application of a new method for stability and forced response analyses of aerodynamically coupled blades considering the interaction of various mode families. The method, here referred as multimode least square, considers the unsteady forces due to the blade motion at different modes shape families and calculates the aerodynamic matrixes by means of a least square (L2) approximations. This approach permits the prediction of mode families' interaction with capabilities of structural, aerodynamic and force mistuning. A projection technique is implemented in order to reduce the computational domain. Application of the method on tuned and structural mistuned forced response and stability analyses is presented on a highly loaded transonic compressor blade. When considering structural mistuning the forced response amplitude magnification is highly affected by the change in aerodynamic damping due to mistuning. Analyses of structural mistuning without aerodynamic coupling might result in over-estimated or under-estimated response when the source of damping is mainly aerodynamic. The frequency split due to mistuning can cause that mode families' interact due to reducing their frequencies separation. The advantage of the present method is that the effect of mode family interaction on aerodynamic damping and forced response is captured not being restricted to single mode families.
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| 5. |
- Mayorca, Maria Angelica, et al.
(author)
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Prediction of Turbomachinery Aeroelastic Behavior From a Set of Representative Modes
- 2013
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In: Journal of turbomachinery. - : ASME International. - 0889-504X .- 1528-8900. ; 135:1, s. 011032-
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Journal article (peer-reviewed)abstract
- A method is proposed for the determination of the aeroelastic behavior of a system responding to mode-shapes which are different from the tuned in vacuo ones, due to mistuning, mode family interaction, or any other source of mode-shape perturbation. The method is based on the generation of a data base of unsteady aerodynamic forces arising from the motion of arbitrary modes and uses least square approximations for the prediction of any responding mode. The use of a reduced order technique allows for mistuning analyses and is also applied for the selection of a limited number of arbitrary modes. The application of this method on a transonic compressor blade shows that the method captures the aeroelastic properties well in a wide frequency range. A discussion of the influence of the mode-shapes and frequency on the final stability response is also provided.
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| 6. |
- Alam, Assad, et al.
(author)
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Look-Ahead Cruise Control for Heavy Duty Vehicle Platooning
- 2013
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In: Proceedings of the 16th International IEEE Annual Conference onIntelligent Transportation Systems (ITSC 2013). - : IEEE conference proceedings. - 9781479929146 ; , s. 928-935
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Conference paper (peer-reviewed)abstract
- Vehicle platooning has become important for thevehicle industry. Yet conclusive results with respect to thefuel reduction possibilities of platooning remain unclear, inparticular when considering constraints imposed by the topography.The focus of this study is to establish whether itis more fuel-efficient to maintain or to split a platoon that isfacing steep uphill and downhill segments. Two commercialcontrollers, an adaptive cruise controller and a look-aheadcruise controller, are evaluated and alternative novel controlstrategies are proposed. The results show that an improvedfuel-efficiency can be obtained by maintaining the platoonthroughout a hill. Hence, a cooperative control strategy basedon preview information is presented, which initiates the changein velocity at a specific point in the road for all vehiclesrather than simultaneously changing the velocity to maintainthe spacing. A fuel reduction of up to 14% can be obtainedover a steep downhill segment and a more subtle benefit of0.7% improvement over an uphill segment with the proposedcontroller, compared to the combination of the commerciallyavailable cruise controller and adaptive cruise controller thatcould be used for platooning. The findings show that it isboth fuel-efficient and desirable in practice to consider previewinformation of the topography in the control strategy.
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| 7. |
- Andersson, Tomas, et al.
(author)
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Photon energy influence on valence photoelectron spectra of silver clusters
- 2012
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In: Journal of Physics, Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 388:15, s. 152028-
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Journal article (peer-reviewed)abstract
- Silver clusters in the size range of ∼102 constituent atoms have been studied using photoelectron spec-troscopy. The 5s and 4d valence bands have been probed with 40 and 60.5 eV photon energies. Differences in the valence band spectral features have been observed and are discussed in view of earlier results on copper clusters and in terms of differences in mean free path for electrons of different energies.
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| 8. |
- Bergh, Ingrid H. E., et al.
(author)
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Midwifery students attribute different quantitative meanings to "hurt", "ache" and "pain" : A cross-sectional survey
- 2013
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In: Women and Birth. - : Elsevier. - 1871-5192 .- 1878-1799. ; 26:2, s. 143-146
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Journal article (peer-reviewed)abstract
- Background: Assessment of women's labor pain is seldom acknowledged in clinical practice or research. The words "aching" and "hurting" are frequently used by women to describe childbirth pain. The aim of this study was to determine the quantitative meanings midwifery students attribute to the terms "hurt", "ache" and "pain". Data was collected by self-administered questionnaire from students at seven Swedish midwifery programs. A total of 230 filled out and returned a completed questionnaire requesting them to rate, on a visual analog scale, the intensity of "hurt", "ache" or "pain" in the back, as reported by a fictitious parturient. Results: The midwifery students attributed, with substantial individual variation, different quantitative meanings to the studied pain descriptors. Conclusions: To be able to communicate about pain with a woman in labor, it is essential that the midwife be familiar with the value of different words and what they mean to her as this may affect her assessment when the woman describes her pain. © 2012.
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| 9. |
- Boldemann, C., et al.
(author)
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Preschool outdoor play environment may combine promotion of children's physical activity and sun protection. Further evidence from Southern Sweden and North Carolina
- 2011
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In: Science and Sports. - : Elsevier BV. - 0765-1597. ; 26:2, s. 72-82
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Conference paper (peer-reviewed)abstract
- Objective. - To study the impact of preschool outdoor environments on children's physical activity and solar ultraviolet (UV) exposure at different latitudes and countries. Methods. Outdoor environments of 11 preschools (two in Raleigh NC, USA, Lat.36 degrees N, nine in Malmo, Sweden, Lat.55 degrees N) were scored (OPEC) regarding space, vegetation, hilly terrain and level of integration between open spaces, vegetation and play structures. Free sky (%) was determined by imaging. Physical activity was measured by pedometers and solar UV-exposure by polysulphone dosimeters during 5 days in spring 2009, and individual background data gathered by questionnaires and anthropometric measurements. Global UV radiation was measured and available individual UV radiation (%) computed. Results. - In Malmo, mean step count/minute was 21.2 in preschools with high-scored environment vs. 17.6 in low-scored environments, and UV-exposure lower, 26% vs. 43% of available UV during outdoor stay. In Raleigh, step count/minute was 12.3 and UV-exposure of available UV 27% during outdoor stay. Conclusions. - Step count/minute was lower in Raleigh than in Malmo, but in Malmo children at low-scored environments ran a higher risk of sunburn than in Raleigh. Trees and shrubbery integrated in children's playscape trigger both physical activity and sun-protective behaviour in Sweden, and previous measurements in Stockholm were confirmed. Such outdoor environment should be recommended, but the role of season and climate needs to be further explored. (C) 2011 Elsevier Masson SAS. All rights reserved.
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| 10. |
- Fruth, Florian, et al.
(author)
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INFLUENCE OF THE BLADE COUNT RATIO ON AERODYNAMIC FORCING PART I : HIGHLY LOADED TRANSONIC COMPRESSOR
- 2010
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Conference paper (peer-reviewed)abstract
- The influence of the Blade Count Ratio (BCR) on the aerodynamic forcing of a highly transonic compressor has been investigated. The focus has been put on the unsteady aerodynamics as well as mode excitability and thus High Cycle Fatigue (HCF) risk. A number of compressor stages were investigated that differed in blade count of the stator blade row. Time-resolved aerodynamic forcing results were acquired using a non-linear CFD approach. The results were decomposed into frequency content and combined with modal properties of the various components. It is found that the BCR is a key parameter to reduce generalized force and consequently vibratory HCF stresses. Furthermore a potential in avoiding and/or alleviating potential resonant crossings in the Campbell diagram is reported. The dependency of these aspects from BCR is largely non-linear and for the first time discussed in detail on the basis of a transonic compressor stage.
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