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- Mellgren, Karin, 1962, et al.
(author)
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Effect of nitric oxide gas on platelets during open heart operations.
- 1998
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In: The Annals of thoracic surgery. - 0003-4975. ; 65:5, s. 1335-41
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Journal article (peer-reviewed)abstract
- The increased bleeding tendency observed after cardiopulmonary bypass is caused in part by thrombocytopenia and impaired platelet function induced by the procedure. Previous in vitro studies have shown that nitric oxide (NO) added to the oxygenator sweep gas reduces platelet activation during experimental perfusion. We evaluated the effect of 40 ppm of NO, added to the oxygenator sweep gas, on platelet consumption and activation in patients undergoing cardiopulmonary bypass.
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- Mellgren, Karin, 1962, et al.
(author)
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Nitric oxide in the oxygenator sweep gas reduces platelet activation during experimental perfusion.
- 1996
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In: The Annals of thoracic surgery. - 0003-4975. ; 61:4, s. 1194-8
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Journal article (peer-reviewed)abstract
- Hemorrhage is a major complication experienced in 10% to 35% of neonates treated with extracorporeal life support (ECLS). The increased bleeding tendency is partly due to an ECLS-induced thrombocytopenia and impaired platelet function. In the present study, we evaluated the effect of nitric oxide on the ECLS-induced platelet consumption and activation.
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- Mellgren, Karin, 1962, et al.
(author)
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Platelet activation and degradation in an experimental extracorporeal system. A comparison between a silicone membrane and a hollow-fibre oxygenator.
- 1996
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In: Perfusion. - 0267-6591. ; 11:5, s. 383-8
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Journal article (peer-reviewed)abstract
- Blood platelets are rapidly activated in contact with biomaterials and, therefore, can be used as markers of the biocompatibility of various components in an extracorporeal system. In the present work two different oxygenators, one membrane oxygenator (Avecor) and one hollow-fibre oxygenator ("Lilliput', Dideco) were compared. Complete in vitro extracorporeal membrane oxygenation circuits were perfused with fresh, heparinized human blood for 24 h. Eight experiments were performed with the hollow-fibre oxygenator and five experiments with the membrane oxygenator. Blood gases, electrolytes, glucose and haematocrit were kept within physiological limits. Platelet count, plasma concentration of beta-thromboglobulin, platelet serotonin content, platelet membrane glycoprotein lb and its degradation product glycocalicin, as well as plasma haemoglobin concentration were assayed. As regards most of these variables, significant differences in favour of the hollow-fibre oxygenator were observed.
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