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- Malerba, Franco, et al.
(author)
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Knowledge-intensive Innovative Entrepreneurship integrating Schumpeter, evolutionary economics and innovation systems
- 2020
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In: Small Business Economics. - : Springer Science and Business Media LLC. - 0921-898X .- 1573-0913. ; 54:2, s. 503-522
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Journal article (peer-reviewed)abstract
- This article proposes a novel conceptualization of knowledge-intensive innovative entrepreneurship, which can capture the main characteristics of a vital phenomenon in the modern economy. Our conceptualization is based upon the integration of Schumpeterian entrepreneurship, evolutionary economics, and innovation systems approach. It consists of a theoretical definition and a stylized process model. According to this view, knowledge-intensive innovative entrepreneurs are involved in the creation, diffusion, and use of knowledge; introduce new products and technologies; draw resources and ideas from their innovation system; and introduce change and dynamism into the economy. In the article, we also offer an empirical definition of knowledge-intensive innovative entrepreneurship, which we then use to identify its key characteristics and relevance. We conclude with recommendations for a future research agenda.
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- Surendran, Praveen, et al.
(author)
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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
- 2020
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 52:12, s. 1314-1332
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Journal article (peer-reviewed)abstract
- Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.
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