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- Sondergaard, E., et al.
(author)
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ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
- 2019
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 29:9
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Journal article (peer-reviewed)abstract
- B cell development depends on the coordinated expression and cooperation of several transcription factors. Here we show that the transcription factor ETS-related gene (ERG) is crucial for normal B cell development and that its deletion results in a substantial loss of bone marrow B cell progenitors and peripheral B cells, as well as a skewing of splenic B cell populations. We find that ERG-deficient B lineage cells exhibit an early developmental block at the pre-B cell stage and proliferate less. The cells fail to express the immunoglobulin heavy chain due to inefficient V-to-DJ recombination, and cells that undergo recombination display a strong bias against incorporation of distal V gene segments. Furthermore, antisense transcription at PAX5-activated intergenic repeat (PAIR) elements, located in the distal region of the Igh locus, depends on ERG. These findings show that ERG serves as a critical regulator of B cell development by ensuring efficient and balanced V-to-DJ recombination.
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- Kahn, B, et al.
(author)
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Women in metabolism: part I
- 2015
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In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 21:5, s. 654-657
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Journal article (peer-reviewed)
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