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1.	Alcolea, Daniel, et al. (author) Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: A Multicenter Study in Spain. 2014 In: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 39:4, s. 719-726 Journal article (peer-reviewed)abstract Lumbar puncture (LP) is increasingly performed in memory units due to the usefulness of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease. The feasibility of this procedure in this context, however, is controversial.
2.	López, Miguel, et al. (author) Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance 2010 In: Nature Medicine. - : Nature Publishing Group. - 1078-8956 .- 1546-170X. ; 16:9, s. 1001-1008 Journal article (peer-reviewed)abstract Thyroid hormones have widespread cellular effects; however it is unclear whether their effects on the central nervous system (CNS) contribute to global energy balance. Here we demonstrate that either whole-body hyperthyroidism or central administration of triiodothyronine (T3) decreases the activity of hypothalamic AMP-activated protein kinase (AMPK), increases sympathetic nervous system (SNS) activity and upregulates thermogenic markers in brown adipose tissue (BAT). Inhibition of the lipogenic pathway in the ventromedial nucleus of the hypothalamus (VMH) prevents CNS-mediated activation of BAT by thyroid hormone and reverses the weight loss associated with hyperthyroidism. Similarly, inhibition of thyroid hormone receptors in the VMH reverses the weight loss associated with hyperthyroidism. This regulatory mechanism depends on AMPK inactivation, as genetic inhibition of this enzyme in the VMH of euthyroid rats induces feeding-independent weight loss and increases expression of thermogenic markers in BAT. These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Blennow, Kaj, 1958 (1); Orešič, Matej, 1967- (1); Molinuevo, José Luis (1); Alcolea, Daniel (1); Martínez-Lage, Pablo (1); Izagirre, Andrea (1); show more...; Clerigué, Montserrat (1); Carmona-Iragui, Marí ... (1); Alvarez, Rosa María (1); Fortea, Juan (1); Balasa, Mircea (1); Morenas-Rodríguez, E ... (1); Lladó, Albert (1); Grau, Oriol (1); Lleó, Alberto (1); Dieguez, Carlos (1); Lopez, Miguel (1); Rodriguez-Cuenca, Se ... (1); Vidal-Puig, Antonio (1); Chatterjee, Krishna (1); Velagapudi, Vidya R. (1); Lelliott, Christophe ... (1); Varela, Luis (1); Vázquez, María J (1); González, Carmen R. (1); Morgan, Donald A. (1); Schoenmakers, Erik (1); Agassandian, Khristo ... (1); Lage, Ricardo (1); Martínez de Morentin ... (1); Tovar, Sulay (1); Nogueiras, Rubén (1); Carling, David (1); Gallego, Rosalía (1); Saha, Asish K (1); Rahmouni, Kamal (1); show less...

University: University of Gothenburg (1); Örebro University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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