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1.	Jakobsson, J., et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Journal article (peer-reviewed)
2.	2021 swepub:Mat__t
3.	Barker, CJ, et al. (author) XPR1 Mediates the Pancreatic β-Cell Phosphate Flush 2021 In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 70:1, s. 111-118 Journal article (peer-reviewed)abstract Glucose-stimulated insulin secretion is the hallmark of the pancreatic β-cell, a critical player in the regulation of blood glucose concentration. In 1974, the remarkable observation was made that an efflux of intracellular inorganic phosphate (Pi) accompanied the events of stimulated insulin secretion. The mechanism behind this “phosphate flush,” its association with insulin secretion, and its regulation have since then remained a mystery. We recapitulated the phosphate flush in the MIN6m9 β-cell line and pseudoislets. We demonstrated that knockdown of XPR1, a phosphate transporter present in MIN6m9 cells and pancreatic islets, prevented this flush. Concomitantly, XPR1 silencing led to intracellular Pi accumulation and a potential impact on Ca2+ signaling. XPR1 knockdown slightly blunted first-phase glucose-stimulated insulin secretion in MIN6m9 cells, but had no significant impact on pseudoislet secretion. In keeping with other cell types, basal Pi efflux was stimulated by inositol pyrophosphates, and basal intracellular Pi accumulated following knockdown of inositol hexakisphosphate kinases. However, the glucose-driven phosphate flush occurred despite inositol pyrophosphate depletion. Finally, while it is unlikely that XPR1 directly affects exocytosis, it may protect Ca2+ signaling. Thus, we have revealed XPR1 as the missing mediator of the phosphate flush, shedding light on a 45-year-old mystery.
4.	Bousquet, J, et al. (author) Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19 2021 In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 76:3, s. 735-750 Journal article (peer-reviewed)
5.	Jahagirdar, D, et al. (author) Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990-2019, for 204 countries and territories: the Global Burden of Diseases Study 2019 2021 In: The lancet. HIV. - 2352-3018. ; 8:10, s. E633-E651 Journal article (peer-reviewed)
6.	Niemi, MEK, et al. (author) 2021 swepub:Mat__t

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Gupta, S. (3); Kumar, S (3); Liu, X (2); Chen, L (2); Brown, J. (2); Chen, S. (2); show more...; Davies, M. (2); Price, D. (2); Wang, C. (2); Wang, H. (2); Williams, S. (2); Zhang, H. (2); Zhang, L. (2); Liu, J. (2); Lange, C. (2); Davies, E. (2); Gupta, A. (2); Li, J. (2); Smith, M. (2); Martin, J. (2); Park, J (2); Brown, A. (2); Zhang, Y. (2); Jones, M. (2); Kumar, A. (2); Jain, S. (2); Williams, G. (2); Gomez, R. (2); Mahajan, A. (2); Singh, R. (2); Hussain, S. (2); Jones, R. (2); Roberts, M. (2); Khan, A. (2); Lee, S (2); Lee, M (2); Thomas, E. (2); Ali, M (2); Ali, S (2); Biondi, A (2); Hassan, S (2); Khan, M (2); Kumar, M (2); Lin, C (2); Mohammad, Y (2); Pereira, A (2); Rahim, F (2); Singh, A (2); Wang, YZ (2); Russo, R. (2); show less...

University: Karolinska Institutet (5); Umeå University (1); Stockholm University (1); Linköping University (1); Lund University (1); Swedish University of Agricultural Sciences (1)

Language: English (6)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year: 2021 (6)Undo refine

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