| 1. |
- Ongena, J., et al.
(author)
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Recent progress on JET towards the ITER reference mode of operation at high density
- 2001
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In: Plasma Physics and Controlled Fusion. - 0741-3335 .- 1361-6587. ; 43, s. A11-A30
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Journal article (peer-reviewed)abstract
- Recent progress towards obtaining high density and high confinement in JET as required for the ITER reference scenario at Q = 10 is summarized. Plasmas with simultaneous confinement H-98(y.2) = 1 and densities up to n/n(Gw) similar to 1 are now routinely obtained. This has been possible (i) by using plasmas at high (delta similar to 0.5) and medium (delta similar to 0.3-0.4) triangularity with sufficient heating power to maintain Type I ELMs, (ii) with impurity seeded plasmas at high (delta similar to 0.5) and low (delta less than or equal to 0.2) triangularity, (iii) with an optimized pellet injection sequence, maintaining the energy confinement and raising the density, and (iv) by carefully tuning the gas puff rate leading to plasmas with peaked density profiles and good confinement at long time scales. These high performance discharges exhibit Type I ELMs, with a new and more favourable behaviour observed at high densities, requiring further studies. Techniques for a possible mitigation of these ELMs are discussed, and first promising results are obtained with impurity seeding in discharges at high triangularity. Scaling studies using the new data of this year show a strong dependence of confinement on upper triangularity, density and proximity to the Greenwald limit. Observed MHD instabilities and methods to avoid these in high density and high confinement plasmas are discussed.
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| 2. |
- Eriksson, L-G, et al.
(author)
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Destabilization of fast-ion-induced long sawteeth by localized current drive in the JET tokamak.
- 2004
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 92:23
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Journal article (peer-reviewed)abstract
- In a tokamak fusion reactor the energetic alpha particles will transiently stabilize the magnetohydrodynamic activity causing sawtooth oscillations. The crash events terminating long sawtooth free periods can provide seed islands for neoclassical tearing modes [Phys. Rev. Lett. 88, 105001 (2002)]]. To shorten the sawtooth periods localized current drive near the q=1 surface is a possibility. This Letter provides the first experimental evidence for the effectiveness of this method in the different physics regime associated with fast-ion-induced long sawteeth on the JET tokamak.
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| 3. |
- Valovic, M., et al.
(author)
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Density peaking in low collisionality ELMy H-mode in JET
- 2004
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In: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 46:12, s. 1877-1889
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Journal article (peer-reviewed)abstract
- Low collisionality, low particle source. ELMy H-modes (type-III) with sawteeth are produced in JET in order to address the question of density profile evolution in the reference q(95) = 3 ITER scenario. The paper focuses on particle transport in the core zone around the mid-radius. The pedestal region including ELMs and the region affected by sawteeth are not considered. By replacing a significant part of the neutral beam heating by RF power the beam particle flux at mid-radius has been reduced to Gamma(Beam)/n(e) = 0.07 m s(-1). The additional flux due to wall neutrals is estimated as Gamma(Wall)/n(e) = 0.12 m s(-1). Density profiles are found to be modestly peaked under these conditions with a relative density difference of Deltan/(n) = 0.23 across the zone not affected by sawteeth and ELMs. In a region around the mid-radius the ratio of effective particle diffusivity to electron thermal diffusivity is found to be D-e,D-eff/chi(e) approximate to 0.2, which might indicate an anomalous pinch provided the particle diffusivity D-e is sufficiently lame. The measured values of D-e,D-eff/chi(e) are at the lower end of the range used in ITER models.
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| 4. |
- Veikkola, T, et al.
(author)
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Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.
- 2001
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In: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 20:6
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Journal article (peer-reviewed)abstract
- Vascular endothelial growth factor receptor-3 (VEGFR-3) has an essential role in the development of embryonic blood vessels; however, after midgestation its expression becomes restricted mainly to the developing lymphatic vessels. The VEGFR-3 ligand VEGF-C stimulates lymphangiogenesis in transgenic mice and in chick chorioallantoic membrane. As VEGF-C also binds VEGFR-2, which is expressed in lymphatic endothelia, it is not clear which receptors are responsible for the lymphangiogenic effects of VEGF-C. VEGF-D, which binds to the same receptors, has been reported to induce angiogenesis, but its lymphangiogenic potential is not known. In order to define the lymphangiogenic signalling pathway we have created transgenic mice overexpressing a VEGFR-3-specific mutant of VEGF-C (VEGF-C156S) or VEGF-D in epidermal keratinocytes under the keratin 14 promoter. Both transgenes induced the growth of lymphatic vessels in the skin, whereas the blood vessel architecture was not affected. Evidence was also obtained that these growth factors act in a paracrine manner in vivo. These results demonstrate that stimulation of the VEGFR-3 signal transduction pathway is sufficient to induce specifically lymphangiogenesis in vivo.
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