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Search: WFRF:(McManus Patrick) > (2015-2019)

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1.
  • Fairhurst, Gorry, et al. (author)
  • Deliverable D1.1 - NEAT Architecture
  • 2016
  • Reports (peer-reviewed)abstract
    • Ossification of the Internet transport-layer architecture is a significant barrier to innovation of the Internet. Such innovation is desirable for many reasons. Current applications often need to implement their own mechanisms to receive the transport service they need, but many do not have the breadth of adapting to all possible network characteristics. An updated transport architecture can do much to make the Internet more flexible and extensible. New ground-breaking services often require different or updated transport protocols, could benefit from better signalling between application and network, or desire a more flexible choice of which network path is used for which traffic. This document therefore proposes a new transport architecture. Such architecture lowers the barrier to service innovation by proposing a “transport system”, the NEAT System, that can leverage the rich set of available transport protocols. It paves the way for an architectural change of the Internet where new transport-layer services can seamlessly be integrated and quickly made available, minimising deployment difficulties, and allowing Internet innovators to take advantage of them wherever possible. The document provides a survey of the state-of-the-art to identify the architectural obstacles to, and opportunities for, evolution of the transport layer. It also details a set of general requirements for a new transport architecture. This new architecture is motivated by a set of use-cases, followed by a description of the NEAT architecture for a transport system, designed to permit applications to select appropriate transports based on their needs and the available transport services.
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2.
  • Roselli, Carolina, et al. (author)
  • Multi-ethnic genome-wide association study for atrial fibrillation
  • 2018
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
  • Journal article (peer-reviewed)abstract
    • Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
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