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1.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
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2.
  • Satizabal, Claudia L., et al. (author)
  • Genetic architecture of subcortical brain structures in 38,851 individuals
  • 2019
  • In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
  • Journal article (peer-reviewed)abstract
    • Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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journal article (2)
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other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Franke, Barbara (1)
Westman, Eric (1)
Rothhaupt, Karl-Otto (1)
Tsolaki, Magda (1)
Ching, Christopher R ... (1)
Agartz, Ingrid (1)
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Brouwer, Rachel M (1)
Melle, Ingrid (1)
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Thompson, Paul M (1)
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Farrell, Katharine N ... (1)
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Axelsson, Tomas (1)
Islar, Mine (1)
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Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
van der Wee, Nic J. ... (1)
Lukic, Marko (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Ikram, M. Arfan (1)
Amin, Najaf (1)
van Duijn, Cornelia ... (1)
Chen, Qiang (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Rotter, Jerome I. (1)
Soininen, Hilkka (1)
Vajda, Vivi (1)
Weinberger, Daniel R (1)
Pascual, Unai (1)
de Geus, Eco J. C. (1)
Martin, Nicholas G. (1)
Boomsma, Dorret I. (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
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University
Umeå University (1)
Royal Institute of Technology (1)
Uppsala University (1)
Lund University (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
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Karolinska Institutet (1)
Swedish University of Agricultural Sciences (1)
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Language
English (2)
Research subject (UKÄ/SCB)
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Engineering and Technology (1)
Medical and Health Sciences (1)
Social Sciences (1)
Year
2019 (2)Undo refine

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