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Träfflista för sökning "WFRF:(Meyer Thomas) srt2:(2015-2019)"

Search: WFRF:(Meyer Thomas) > (2015-2019)

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  • Hibar, Derrek P., et al. (author)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Journal article (peer-reviewed)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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  • Aad, G, et al. (author)
  • 2015
  • swepub:Mat__t
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  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
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  • Result 1-10 of 234
Type of publication
journal article (222)
research review (7)
conference paper (2)
book chapter (1)
Type of content
peer-reviewed (228)
other academic/artistic (4)
Author/Editor
Esposito, B. (137)
Chen, C. (118)
Chen, S. (118)
Alonso, A. (117)
Bai, Y. (117)
Chen, H. (117)
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Aoki, M. (116)
Chen, X. (116)
Chen, Y. (116)
Endo, M. (116)
Chen, L (115)
Aielli, G. (115)
Alonso, F. (115)
Amorim, A. (115)
Amram, N. (115)
Anders, G. (115)
Anjos, N. (115)
Annovi, A. (115)
Anulli, F. (115)
Arai, Y. (115)
Artoni, G. (115)
Avolio, G. (115)
Backes, M. (115)
Beck, H. P. (115)
Bell, W. H. (115)
Bellomo, M. (115)
Bernard, C. (115)
Bianco, M. (115)
Bindi, M. (115)
Blair, R. E. (115)
Bold, T. (115)
Boveia, A. (115)
Brock, R. (115)
Bruni, A. (115)
Calvet, S. (115)
Cao, T. (115)
Casadei, D. (115)
Cerri, A. (115)
Cerrito, L. (115)
Coccaro, A. (115)
Corradi, M. (115)
Cranmer, K. (115)
Dam, M. (115)
Dao, V. (115)
Demers, S. (115)
Ellis, N. (115)
Ernst, J. (115)
Etzion, E. (115)
Fedorko, W. (115)
Ferrer, A. (115)
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University
Uppsala University (143)
Lund University (134)
Royal Institute of Technology (121)
Stockholm University (106)
Karolinska Institutet (34)
Chalmers University of Technology (32)
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Umeå University (25)
Linköping University (12)
University of Gothenburg (4)
Swedish University of Agricultural Sciences (2)
Stockholm School of Economics (1)
Mid Sweden University (1)
Linnaeus University (1)
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Language
English (234)
Research subject (UKÄ/SCB)
Natural sciences (181)
Medical and Health Sciences (43)
Engineering and Technology (15)
Social Sciences (4)
Agricultural Sciences (2)

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