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Träfflista för sökning "WFRF:(Michel R) srt2:(2020-2024)"

Search: WFRF:(Michel R) > (2020-2024)

  • Result 1-10 of 142
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  • 2021
  • swepub:Mat__t
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  • Bravo, L, et al. (author)
  • 2021
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  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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  • 2021
  • swepub:Mat__t
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  • Glasbey, JC, et al. (author)
  • 2021
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  • Vogel, Jacob W., et al. (author)
  • Four distinct trajectories of tau deposition identified in Alzheimer’s disease
  • 2021
  • In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
  • Journal article (peer-reviewed)abstract
    • Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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  • Bousquet, J, et al. (author)
  • Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
  • 2020
  • In: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
  • Journal article (peer-reviewed)abstract
    • There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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  • Result 1-10 of 142
Type of publication
journal article (122)
research review (13)
other publication (1)
conference paper (1)
Type of content
peer-reviewed (130)
other academic/artistic (7)
Author/Editor
Michel, P. (10)
Pereira, A (8)
Michel, M (8)
Lopes, L. (7)
Vieta, Eduard (7)
Smith, L (7)
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Losada, M. (6)
Romano, M. (6)
Davies, E. (6)
Martin, J. (6)
Aytac, E (6)
Davies, RJ (6)
Hompes, R (6)
Lakkis, Z (6)
Tsarkov, P (6)
Silva, M. (6)
Moore, R. (6)
Russ, J. (6)
Sharma, N. (6)
Singh, R. (6)
Nowak, K. (6)
Costa, M. (6)
Michel, C. (6)
Clark, J. (6)
Patel, P. (6)
Khan, A. (6)
Abate, E. (6)
Lee, M (6)
Ali, M (6)
Ali, S (6)
Negoi, I (6)
Salem, H (6)
Singh, A (6)
Shah, S (6)
Desai, A. (6)
Evans, J. (6)
Young, R. (6)
Sharma, P. (6)
Abdalla, M. (6)
Santos, R. (6)
Conti, L. (6)
Sherif, A. (6)
Bhalla, A (6)
Green, S (6)
Pereira, R (6)
Khan, T. (6)
Vanacker, P. (6)
Smith, J. (6)
Cox, D (6)
Vitali, A (6)
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University
Karolinska Institutet (55)
University of Gothenburg (36)
Uppsala University (30)
Lund University (18)
Stockholm University (10)
Linköping University (9)
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Chalmers University of Technology (7)
Umeå University (5)
Royal Institute of Technology (4)
Luleå University of Technology (4)
Kristianstad University College (3)
Örebro University (2)
Malmö University (2)
RISE (2)
Halmstad University (1)
University of Gävle (1)
University West (1)
Stockholm School of Economics (1)
Swedish University of Agricultural Sciences (1)
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Language
English (142)
Research subject (UKÄ/SCB)
Medical and Health Sciences (72)
Natural sciences (37)
Engineering and Technology (6)
Social Sciences (6)
Agricultural Sciences (1)
Humanities (1)

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