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- Agrawal, Ganesh Kumar, et al.
(author)
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Boosting the Globalization of Plant Proteomics through INPPO : Current Developments and Future Prospects
- 2012
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In: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 12:3, s. 359-368
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Journal article (peer-reviewed)abstract
- The International Plant Proteomics Organization (INPPO) is a non-profit-organization consisting of people who are involved or interested in plant proteomics. INPPO is constantly growing in volume and activity, which is mostly due to the realization among plant proteomics researchers worldwide for the need of such a global platform. Their active participation resulted in the rapid growth within the first year of INPPO's official launch in 2011 via its website (www.inppo.com) and publication of the 'Viewpoint paper' in a special issue of PROTEOMICS (May 2011). Here, we will be highlighting the progress achieved in the year 2011 and the future targets for the year 2012 and onwards. INPPO has achieved a successful administrative structure, the Core Committee (CC; composed of President, Vice-President, and General Secretaries), Executive Council (EC), and General Body (GB) to achieve INPPO objectives. Various committees and subcommittees are in the process of being functionalized via discussion amongst scientists around the globe. INPPO's primary aim to popularize the plant proteomics research in biological sciences has also been recognized by PROTEOMICS where a section dedicated to plant proteomics has been introduced starting January 2012, following the very first issue of this journal devoted to plant proteomics in May 2011. To disseminate organizational activities to the scientific community, INPPO has launched a biannual (in January and July) newsletter entitled 'INPPO Express: News & Views' with the first issue published in January 2012. INPPO is also planning to have several activities in 2012, including programs within the Education Outreach committee in different countries, and the development of research ideas and proposals with priority on crop and horticultural plants, while keeping tight interactions with proteomics programs on model plants such as Arabidopsis thaliana, rice, and Medicago truncatula. Altogether, the INPPO progress and upcoming activities are because of immense support, dedication, and hard work of all members of the INPPO community, and also due to the wide encouragement and support from the communities (scientific and non-scientific).
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- Tyndall, Anthony J., et al.
(author)
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Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database
- 2010
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In: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 69:10, s. 1809-1815
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Journal article (peer-reviewed)abstract
- Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox proportional hazards models were used to analyse survival in SSc subgroups and to identify predictors of mortality. Results Questionnaires were obtained on 234 of 284 fatalities. 55% of deaths were attributed directly to SSc and 41% to non-SSc causes; in 4% the cause of death was not assigned. Of the SSc-related deaths, 35% were attributed to pulmonary fibrosis, 26% to pulmonary arterial hypertension (PAH) and 26% to cardiac causes (mainly heart failure and arrhythmias). Among the non-SSc-related causes, infections (33%) and malignancies (31%) were followed by cardiovascular causes (29%). Of the non-SSc-related fatalities, 25% died of causes in which SSc-related complications may have participated (pneumonia, sepsis and gastrointestinal haemorrhage). Independent risk factors for mortality and their HR were: proteinuria (HR 3.34), the presence of PAH based on echocardiography (HR 2.02), pulmonary restriction (forced vital capacity below 80% of normal, HR 1.64), dyspnoea above New York Heart Association class II (HR 1.61), diffusing capacity of the lung (HR 1.20 per 10% decrease), patient age at onset of Raynaud's phenomenon (HR 1.30 per 10 years) and the modified Rodnan skin score (HR 1.20 per 10 score points). Conclusion Disease-related causes, in particular pulmonary fibrosis, PAH and cardiac causes, accounted for the majority of deaths in SSc.
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- Byakika-Kibwika, Pauline, et al.
(author)
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Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults.
- 2012
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In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press (OUP). - 0305-7453 .- 1460-2091. ; 67:5, s. 1217-23
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Journal article (peer-reviewed)abstract
- BACKGROUND: Treatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisinin-based combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine after administration of a single dose of 80/480 mg of artemether/lumefantrine to HIV-infected adults, taken with and without lopinavir/ritonavir.METHODS: A two-arm parallel study of 13 HIV-infected ART-naive adults and 16 HIV-infected adults stable on 400/100 mg of lopinavir/ritonavir plus two nucleoside reverse transcriptase inhibitors (ClinicalTrials.gov, NCT 00619944). Each participant received a single dose of 80/480 mg of artemether/lumefantrine under continuous cardiac function monitoring. Plasma concentrations of artemether, dihydroartemisinin and lumefantrine were measured.RESULTS: Co-administration of artemether/lumefantrine with lopinavir/ritonavir significantly reduced artemether maximum concentration (C(max)) and area under the concentration-time curve (AUC) [median (range): 112 (20-362) versus 56 (17-236) ng/mL, P = 0.03; and 264 (92-1129) versus 151 (38-606) ng · h/mL, P < 0.01]. Dihydroartemisinin C(max) and AUC were not affected [66 (10-111) versus 73 (31-224) ng/mL, P = 0.55; and 213 (68-343) versus 175 (118-262) ng · h/mL P = 0.27]. Lumefantrine C(max) and AUC increased during co-administration [2532 (1071-5957) versus 7097 (2396-9462) ng/mL, P < 0.01; and 41,119 (12,850-125,200) versus 199,678 (71,205-251,015) ng · h/mL, P < 0.01].CONCLUSIONS: Co-administration of artemether/lumefantrine with lopinavir/ritonavir significantly increases lumefantrine exposure, but decreases artemether exposure. Population pharmacokinetic and pharmacodynamic trials will be highly valuable in evaluating the clinical significance of this interaction and determining whether dosage modifications are indicated.
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- Codita, Alina, et al.
(author)
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Effects of spatial and cognitive enrichment on activity pattern and learning performance in three strains of mice in the IntelliMaze.
- 2012
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In: Behavior Genetics. - : Springer Science and Business Media LLC. - 0001-8244 .- 1573-3297. ; 42:3, s. 449-460
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Journal article (peer-reviewed)abstract
- The IntelliMaze allows automated behavioral analysis of group housed laboratory mice while individually assigned protocols can be applied concomitantly for different operant conditioning components. Here we evaluate the effect of additional component availability (enrichment) on behavioral and cognitive performance of mice in the IntelliCage, by focusing on aspects that had previously been found to consistently differ between three strains, in four European laboratories. Enrichment decreased the activity level in the IntelliCages and enhanced spatial learning performance. However, it did not alter strain differences, except for activity during the initial experimental phase. Our results from non-enriched IntelliCages proved consistent between laboratories, but overall laboratory-consistency for data collected using different IntelliCage set-ups, did not hold for activity levels during the initial adaptation phase. Our results suggest that the multiple conditioning in spatially and cognitively enriched environments are feasible without affecting external validity for a specific task, provided animals have adapted to such an IntelliMaze.
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| 8. |
- Dahbi, Mohammed, et al.
(author)
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Electrochemical behavior of LiNi1-y-zCoyMnzO2 probed through structural and magnetic properties
- 2012
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In: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 111:2, s. 023904-
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Journal article (peer-reviewed)abstract
- We have investigated LixNi1-y-zCoyMnzO2 compounds with y = 1/3, 0.25, 0.2, 0.1 and z = 1/3, 0.2, 0.1, 0.05 in order to study the influence of Ni and Mn concentration, cationic disorder, and crystallite size on the magnetic and charge/discharge behavior. The samples have been studied by means of x-ray diffraction, scanning electron microscopy, voltammetry, cycling capacity, and magnetometry. The discharge capacity increases with increasing Ni concentration as does the number of ferromagnetic interactions. With higher Mn concentration a higher capacity is observed together with formation of strong antiferromagnetic interactions driving the magnetic frustration to lower temperatures. Our results show that for sufficiently low Co concentrations a stable and magnetically more ordered structure can be obtained with excellent electrochemical properties, although a relatively large amount of Ni is present.
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- Georgoulas, George, et al.
(author)
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Principal component analysis of the start-up transient and hidden Markov modeling for broken rotor bar fault diagnosis in asynchronous machines
- 2013
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In: Expert systems with applications. - : Elsevier BV. - 0957-4174 .- 1873-6793. ; 40:17, s. 7024-7033
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Journal article (peer-reviewed)abstract
- This article presents a novel computational method for the diagnosis of broken rotor bars in three phase asynchronous machines. The proposed method is based on Principal Component Analysis (PCA) and is applied to the stator’s three phase start-up current. The fault detection is easier in the start-up transient because of the increased current in the rotor circuit, which amplifies the effects of the fault in the stator’s current independently of the motor’s load. In the proposed fault detection methodology, PCA is initially utilized to extract a characteristic component, which reflects the rotor asymmetry caused by the broken bars. This component can be subsequently processed using Hidden Markov Models (HMMs). Two schemes, a multiclass and a one-class approach are proposed. The efficiency of the novel proposed schemes is evaluated by multiple experimental test cases. The results obtained indicate that the suggested approaches based on the combination of PCA and HMM, can be successfully utilized not only for identifying the presence of a broken bar but also for estimating the severity (number of broken bars) of the fault.
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| 10. |
- Hatem, Mohammed, et al.
(author)
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Rheological Properties of Cement-Based Grouts Determined by Different Techniques
- 2014
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In: Engineering. - : Scientific Research Publishing, Inc.. - 1947-3931 .- 1947-394X. ; 6:5, s. 217-229
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Journal article (peer-reviewed)abstract
- The rheological properties of cement-based grouts containing talc or palygorskite were investigated for optimizing fluidity and quick strengthening at injection. The fluidity controls the ability of grout to penetrate fractures and can be determined by pipe flow tests, Marsh funnel tests, mini-slump cone tests and rheometer tests. The grouts were 1) Talc for fluidity and strength by reacting with cement, 2) Palygorskite (attapulgite) for early gelation by being thixotropic, and 3) Powdered quartz for chemical integrity. The freshly prepared grouts behaved as Bingham fluids with viscosities from 0.151 to 0.464 Pas and yield stresses 5.2 Pa to 36.7 Pa. Statistical analysis of the flow test data converted Marsh flow time into viscosity. The pipe flow tests gave 26.5% higher values than the viscometer for grout with Portland cement and talc, and about 13.7% lower than the viscometer data for the grout with low-pH cement and talc. The big Marsh funnel gave valuesdiffering by 5.2% - 5.3% from those of the viscometer for grout with talc and Portland, and Merit 5000 cements. For grout with palygorskite the viscosity was at least twice that of the other grouts. Grout fluidity was positively affected by talc and negatively by palygorskite and early cement hydration
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