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- Su, Zhan, et al.
(author)
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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.
- 2012
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:10
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Journal article (peer-reviewed)abstract
- Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (Pcombined=4.09×10(-9); odds ratio (OR)=1.21, 95% confidence interval (CI)=1.13-1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (Pcombined=2.74×10(-10); OR=1.14, 95% CI=1.10-1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus.
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| 5. |
- Peters, Daniel L., et al.
(author)
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A multi-scale hydroclimatic analysis of runoff generation in the Athabasca River, western Canada
- 2013
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In: Hydrological Processes. - : Wiley. - 1099-1085 .- 0885-6087. ; 27:13, s. 1915-1934
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Journal article (peer-reviewed)abstract
- A multi-scale hydroclimatic study of runoff generation in the Athabasca River watershed located in western Canada is presented. Mann-Kendall trend detection tests performed on hydrometric data for the lower Athabasca River (LAR) revealed predominantly significant (p<0.05) declines in annual and open-water season median/mean runoff indices over 1958-2009, with the ice-influenced season experiencing significant declines in the median and not the mean. The presence or absence of significant declines in the 25th and 75th runoff percentiles helped explain these results. The only noteworthy result from the mid-point of the watershed was a probable (p<0.10) decline in median open-water runoff, which was not seen over the 1913-2009 period. Divergent seasonal runoff trends from the headwater zone were seen since 1958 and back to 1913, increasing ice-influenced and declining open-water season runoff trends. Although precipitation was observed to decline over 1958-2009, only the LAR watershed scale annual index emerged as a probable decline. Multiple non-linear regression analysis indicated that variation in precipitation explained >67% of the annual median/mean LAR runoff variability since 1958. A first-order precipitation driven hindcasting model suggested that LAR watershed scale runoff may have increased since 1913, warranting further study. A correlation analysis of climatic teleconnections with median/mean runoff indices revealed that the winter North Pacific American index showed a strong, positive association with open-water runoff. The results from our study demonstrated that potentially inconsistent and/or divergent trend results can be obtained when using different time periods and/or regions of the watershed, emphasizing that extreme caution should be exercised when extrapolating sub-watershed results to the watershed scale, or to adjacent watersheds. Our multi-scale study approach also identified the drainage area between Athabasca and Fort McMurray as a zone that influenced runoff declines observed at the LAR watershed scale since 1958, which warrants further investigation with competent hydrological models. Copyright (c) 2013 John Wiley & Sons Ltd and Her Majesty the Queen in Right of Canada Reproduced with the permission of the Ministry of the Environment.
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| 6. |
- Aad, G, et al.
(author)
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- 2014
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In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:17
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Journal article (peer-reviewed)
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| 8. |
- Aad, G., et al.
(author)
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Commissioning of the ATLAS Muon Spectrometer with cosmic rays
- 2010
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 70:3, s. 875-916
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Journal article (peer-reviewed)abstract
- The ATLAS detector at the Large Hadron Collider has collected several hundred million cosmic ray events during 2008 and 2009. These data were used to commission the Muon Spectrometer and to study the performance of the trigger and tracking chambers, their alignment, the detector control system, the data acquisition and the analysis programs. We present the performance in the relevant parameters that determine the quality of the muon measurement. We discuss the single element efficiency, resolution and noise rates, the calibration method of the detector response and of the alignment system, the track reconstruction efficiency and the momentum measurement. The results show that the detector is close to the design performance and that the Muon Spectrometer is ready to detect muons produced in high energy proton-proton collisions.
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