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Enumeration	Reference	Cover	Find
1.	Klionsky, Daniel J, et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 12:1, s. 1-222 Journal article (peer-reviewed)
2.	Bravo, L, et al. (author) 2021 swepub:Mat__t
3.	Tabiri, S, et al. (author) 2021 swepub:Mat__t
4.	Tran, Seav-Ly, et al. (author) Haemolysin II is a Bacillus cereus virulence factor that induces apoptosis of macrophages 2011 In: Cellular Microbiology. - : Hindawi Limited. - 1462-5814 .- 1462-5822. ; 13:1, s. 92-108 Journal article (peer-reviewed)abstract Bacillus cereus is a Gram-positive spore-forming bacterium causing food poisoning and serious opportunistic infections. These infections are characterized by bacterial accumulation despite the recruitment of phagocytic cells. The precise mechanisms and the bacterial factors allowing B. cereus to circumvent host immune responses remain to be elucidated. We have previously shown that B. cereus induces macrophage cell death by an unknown mechanism. Here we identified the toxic component from the B. cereus supernatant. We report that Haemolysin II (HlyII) provokes macrophage cell death by apoptosis through its pore-forming activity. The HlyII-induced apoptotic pathway is caspase 3 and 8 dependent, thus most likely mediated by the death receptor pathway. Using insects and mice as in vivo models, we show that deletion of hlyII strongly reduces virulence. In addition, we show that after infection of Bombyx mori larvae, the immune cells are apoptotic, demonstrating that HlyII induces apoptosis of phagocytic cells in vivo. Altogether, our results clearly unravel HlyII as a novel virulence protein that induces apoptosis in phagocytic cells in vitro and in vivo.
5.	2021 swepub:Mat__t

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Davies, M. (3); King, M. (3); Lopes, L. (3); Losada, M. (3); Negri, G. (3); Qureshi, A. (3); show more...; Robson, A. (3); Romano, M. (3); Morton, A. (3); Davies, E. (3); Valente, P. (3); Liu, T. (3); Bertoli, G (3); Martin, J. (3); Aytac, E (3); Campain, N (3); Davies, RJ (3); Hompes, R (3); Lakkis, Z (3); Maciel, J (3); Rottoli, M (3); Shaikh, (3); Tsarkov, P (3); Brown, A. (3); James, A. (3); Zhang, Y. (3); Silva, M. (3); Diaz, S (3); Jones, M. (3); Moore, R. (3); Russ, J. (3); Shaw, S. (3); Hogan, J. (3); Williams, G. (3); Giraudo, G. (3); Kisiel, A. (3); Kumar, L. (3); Roy, C. (3); Sharma, N. (3); Singh, R. (3); Scott, R. (3); Grassi, T. (3); Tuveri, M. (3); Nowak, K. (3); Costa, M. (3); O'Brien, S. (3); Gill, C. (3); Jones, R. (3); Mohan, M. (3); Roberts, M. (3); show less...

University: Karolinska Institutet (3); Umeå University (2); Stockholm University (1); Linköping University (1); Lund University (1); Swedish University of Agricultural Sciences (1)

Language: English (5)

Research subject (UKÄ/SCB): Natural sciences (2); Medical and Health Sciences (1)

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