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Träfflista för sökning "WFRF:(Morris Simon) srt2:(2015-2019)"

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1.	Evangelou, Evangelos, et al. (author) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 2018 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425 Journal article (peer-reviewed)abstract High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
2.	Shungin, Dmitry, et al. (author) New genetic loci link adipose and insulin biology to body fat distribution. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378 Journal article (peer-reviewed)abstract Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
3.	Wain, Louise V., et al. (author) Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney 2017 In: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. e4-e19 Journal article (peer-reviewed)abstract Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
4.	Aad, G, et al. (author) ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:10 Journal article (peer-reviewed)
5.	Aad, G, et al. (author) Constraints on the off-shell Higgs boson signal strength in the high-mass ZZ and WW final states with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)
6.	Aad, G, et al. (author) Determination of the Ratio of b-Quark Fragmentation Fractions f_{s}/f_{d} in pp Collisions at sqrt[s]=7 TeV with the ATLAS Detector. 2015 In: Physical Review Letters. - : American Physical Society. - 1079-7114 .- 0031-9007. ; 115:26 Journal article (peer-reviewed)
7.	Aad, G, et al. (author) Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in pp Collisions at sqrt[s]=8 TeV Using the ATLAS Detector. 2015 In: Physical Review Letters. - : Elsevier. - 1079-7114 .- 0031-9007. ; 114:14 Journal article (peer-reviewed)
8.	Aad, G, et al. (author) Search for invisible decays of the Higgs boson produced in association with a hadronically decaying vector boson in pp collisions at [Formula: see text] TeV with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)
9.	Aad, G, et al. (author) Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at [Formula: see text]TeV with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)
10.	Aad, G, et al. (author) Search for single top-quark production via flavour-changing neutral currents at 8 TeV with the ATLAS detector. 2016 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 76 Journal article (peer-reviewed)

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Type of publication: journal article (119); conference paper (2); research review (1)

Type of content: peer-reviewed (121); other academic/artistic (1)

Author/Editor: Chen, L (92); Aad, G (92); Abbott, B. (92); Abdinov, O (92); Zwalinski, L. (92); Gregersen, K. (92); show more...; Kalderon, C.W. (92); Poettgen, R. (92); Aben, R. (92); Abreu, H. (92); Abreu, R. (92); Adye, T. (92); Agatonovic-Jovin, T. (92); Ahmadov, F. (92); Aielli, G. (92); Alberghi, G. L. (92); Albert, J. (92); Albrand, S. (92); Aleksa, M. (92); Aleksandrov, I. N. (92); Alexander, G. (92); Alexopoulos, T. (92); Alhroob, M. (92); Alimonti, G. (92); Alio, L. (92); Alonso, A. (92); Alonso, F. (92); Alpigiani, C. (92); Altheimer, A. (92); Amako, K. (92); Amelung, C. (92); Amidei, D. (92); Amorim, A. (92); Amoroso, S. (92); Amram, N. (92); Amundsen, G. (92); Anastopoulos, C. (92); Ancu, L. S. (92); Andari, N. (92); Andeen, T. (92); Anders, G. (92); Anderson, K. J. (92); Andreazza, A. (92); Angelidakis, S. (92); Anger, P. (92); Angerami, A. (92); Anghinolfi, F. (92); Anjos, N. (92); Annovi, A. (92); Antonelli, M. (92); show less...

University: Lund University (100); Uppsala University (92); Stockholm University (81); Royal Institute of Technology (79); Karolinska Institutet (10); University of Gothenburg (7); show more...; Umeå University (4); Chalmers University of Technology (3); Jönköping University (1); Högskolan Dalarna (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (122)

Research subject (UKÄ/SCB): Natural sciences (103); Medical and Health Sciences (21)

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