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Träfflista för sökning "WFRF:(Muller L) srt2:(2020-2024)"

Search: WFRF:(Muller L) > (2020-2024)

  • Result 1-10 of 394
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1.
  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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2.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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3.
  • 2021
  • swepub:Mat__t
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4.
  • Lind, Lars, et al. (author)
  • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)
  • 2021
  • In: eLife. - : eLife Sciences Publications Ltd. - 2050-084X. ; 10
  • Journal article (peer-reviewed)abstract
    • From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
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5.
  • 2021
  • swepub:Mat__t
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6.
  • Bravo, L, et al. (author)
  • 2021
  • swepub:Mat__t
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7.
  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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10.
  • Mishra, A., et al. (author)
  • Stroke genetics informs drug discovery and risk prediction across ancestries
  • 2022
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 611, s. 115-123
  • Journal article (peer-reviewed)abstract
    • Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
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  • Result 1-10 of 394
Type of publication
journal article (366)
conference paper (12)
research review (9)
doctoral thesis (1)
Type of content
peer-reviewed (366)
other academic/artistic (22)
Author/Editor
Takahashi, T. (36)
Quirrenbach, A. (33)
Sasaki, M. (33)
Berge, D. (32)
Lohse, T. (32)
White, R. (32)
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Chen, A. (32)
Aharonian, F. (32)
Becherini, Yvonne (32)
Brun, F. (32)
Egberts, K. (32)
Fontaine, G. (32)
Gabici, S. (32)
Giavitto, G. (32)
Holch, T. L. (32)
Jamrozy, M. (32)
Khelifi, B. (32)
Kosack, K. (32)
Lenain, J. -P (32)
Lypova, I. (32)
Marandon, V. (32)
Moulin, E. (32)
Ohm, S. (32)
Parsons, R. D. (32)
Rowell, G. (32)
Rudak, B. (32)
Schwanke, U. (32)
Wagner, S. J. (32)
Wierzcholska, A. (32)
Zacharias, M. (32)
Backes, M. (31)
Vink, J (31)
Mohrmann, L. (31)
Casanova, S. (31)
Ernenwein, J. -P (31)
Funk, S. (31)
Grondin, M. -H (31)
Jung-Richardt, I. (31)
Lemiere, A. (31)
Moderski, R. (31)
de Naurois, M. (31)
Niemiec, J. (31)
Ostrowski, M. (31)
Panter, M. (31)
Reimer, O. (31)
Rieger, F. (31)
Sahakian, V. (31)
Santangelo, A. (31)
van Eldik, C. (31)
Veh, J. (31)
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University
Karolinska Institutet (146)
University of Gothenburg (66)
Chalmers University of Technology (57)
Stockholm University (46)
Uppsala University (38)
Lund University (38)
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Umeå University (37)
Linnaeus University (32)
Royal Institute of Technology (26)
Linköping University (11)
Luleå University of Technology (5)
University of Skövde (5)
Örebro University (4)
Swedish University of Agricultural Sciences (4)
Jönköping University (2)
RISE (2)
Halmstad University (1)
Swedish Museum of Natural History (1)
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Language
English (393)
German (1)
Research subject (UKÄ/SCB)
Natural sciences (189)
Medical and Health Sciences (96)
Engineering and Technology (24)
Social Sciences (6)
Agricultural Sciences (3)
Humanities (1)

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