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  • Naimi, Timothy S, et al. (author)
  • Selection biases in observational studies affect associations between 'moderate' alcohol consumption and mortality.
  • 2017
  • In: Addiction. - : Wiley. - 0965-2140 .- 1360-0443. ; 112:2, s. 207-214
  • Journal article (peer-reviewed)abstract
    • Selection biases may lead to systematic overestimate of protective effects from 'moderate' alcohol consumption. Overall, most sources of selection bias favor low-volume drinkers in relation to non-drinkers. Studies that attempt to address these types of bias generally find attenuated or non-significant relationships between low-volume alcohol consumption and cardiovascular disease, which is the major source of possible protective effects on mortality from low-volume consumption. Furthermore, observed mortality effects among established low-volume consumers are of limited relevance to health-related decisions about whether to initiate consumption or to continue drinking purposefully into old age. Short of randomized trials with mortality end-points, there are a number of approaches that can minimize selection bias involving low-volume alcohol consumption.
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