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1.	Berenbaum, S, et al. (author) Consensus statement on 21-hydroxylase deficiency from the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society 2002 In: Hormone research. - : S. Karger AG. - 0301-0163. ; 58:4, s. 188-195 Journal article (peer-reviewed)
2.	Berenbaum, S, et al. (author) Consensus statement on 21-hydroxylase deficiency from the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology 2002 In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 87:9, s. 4048-4053 Journal article (peer-reviewed)
3.	Zhao, Ming, et al. (author) Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL 2002 In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 110:6, s. 458-468 Journal article (peer-reviewed)abstract Endocytosis of oxidized low density lipoproteins (oxLDL) by macrophages, mediated by scavenger receptors, is thought to play a central role in foam cell formation and, thus, in the pathogenesis of atherosclerosis. OxLDL activates several MAP kinases, including the ERK, JNK and p38 MAP kinases, but the role of these activations in oxLDL uptake has not been studied. In the present investigation, we find that SB203580, a specific inhibitor of p38, blocks oxLDL-exposed J774 cells from becoming foam cells. Inhibition of foam cell formation by blockade of the p38 pathway is, at least in part, due to inhibition of oxLDL-induced up-regulation of the scavenger receptor CD36. Using pharmaceutical inhibitors and dominant active MAP kinase kinases, we demonstrated that activation of the p38 pathway, but not the ERK or JNK pathways, is necessary and sufficient to transactivate PPAR?, a nuclear receptor that has recently been shown to play a pivotal role in oxLDL-induced CD36 expression. Our results for the first time demonstrate a regulation of CD36 by p38, and the importance of the p38 pathway in regulation of foam cell formation.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Muller, J. (2); Peter, M. (2); Wedell, A (2); Hagenfeldt, K (2); Clayton, P. (2); Saenger, P. (2); show more...; HINTZ, RL (2); Sippell, WG (2); Berenbaum, S (2); Chrousos, G (2); Cutler, G (2); Keizer-Schrama, SD (2); Donahoe, PK (2); Donaldson, M (2); Forest, M (2); Fujieda, K (2); Ginalska-Malinowska, ... (2); Grumbach, MM (2); Gruters, A (2); Honour, JW (2); Hughes, IA (2); Kuhnle-Krahl, U (2); Lee, PA (2); Meyer-Bahlburg, H (2); Migeon, C (2); Miller, WL (2); New, MI (2); Oberfield, SE (2); Ritzen, EM (2); Savage, MO (2); Schober, JM (2); Solyom, J (2); Speiser, PW (2); Therrell, BL (2); Van Wyk, JJ (2); Warne, GL (2); White, PC (2); Wildt, L (2); Witchell, S (2); Hindmarsh, PC (2); Holmes, LB (2); Ibanez, L (2); Levine, LS (2); Wang, X. (1); Zhao, Ming (1); Pang, S (1); Brunk, Ulf (1); Han, J (1); Ghizzoni, L (1); Donohoue, PA (1); show less...

University: Karolinska Institutet (2); Linköping University (1)

Language: English (3)

Year: 2002 (3)

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