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Träfflista för sökning "WFRF:(Nilsson Berith) srt2:(2015-2018)"

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1.	Idborg, H., et al. (author) Systemic lupus erythematosus subgroups, with features of antiphospholipid or Sjogren's syndrome, differ in molecular signatures and treatment perspectives 2018 In: Scandinavian Journal of Rheumatology. - : Taylor & Francis Group. - 0300-9742 .- 1502-7732. ; 47, s. 2-2 Journal article (other academic/artistic)
2.	Sima, Eduardo, Ph.D. 1975-, et al. (author) Complement Proteins In Long-Term Weight Responders And Non-Responders After Gastric Bypass 2017 In: IFSO 2017 22<sup>nd</sup> World Congress. - : Springer. ; , s. 679-679 Conference paper (other academic/artistic)
3.	Jin, Chuan, et al. (author) Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer 2016 In: CANCER IMMUNOLOGY RESEARCH. - 2326-6066. ; 4:1 Journal article (other academic/artistic)
4.	Jin, Chuan, et al. (author) Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer 2016 In: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 8:7, s. 702-711 Journal article (peer-reviewed)abstract Chimeric antigen receptor (CAR) T-cell therapy is a new successful treatment for refractory B-cell leukemia. Successful therapeutic outcome depends on long-term expression of CAR transgene in T cells, which is achieved by delivering transgene using integrating gamma retrovirus (RV) or lentivirus (LV). However, uncontrolled RV/LV integration in host cell genomes has the potential risk of causing insertional mutagenesis. Herein, we describe a novel episomal long-term cell engineering method using non-integrating lentiviral (NILV) vector containing a scaffold/matrix attachment region (S/MAR) element, for either expression of transgenes or silencing of target genes. The insertional events of this vector into the genome of host cells are below detection level. CD19 CAR T cells engineered with a NILV-S/MAR vector have similar levels of CAR expression as T cells engineered with an integrating LV vector, even after numerous rounds of cell division. NILV-S/MAR-engineered CD19 CAR T cells exhibited similar cytotoxic capacity upon CD19(+) target cell recognition as LV-engineered T cells and are as effective in controlling tumor growth in vivo We propose that NILV-S/MAR vectors are superior to current options as they enable long-term transgene expression without the risk of insertional mutagenesis and genotoxicity.

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Type of publication: journal article (3); conference paper (1)

Type of content: other academic/artistic (3); peer-reviewed (1)

Author/Editor: Nilsson, Berith (4); Essand, Magnus (2); Ramachandran, Mohanr ... (2); Fotaki, Grammatiki (2); Jin, Chuan (2); Yu, Di (2); show more...; Nilsson, P. (1); Sundbom, Magnus (1); Nilsson Ekdahl, Kris ... (1); Gustafsson, J (1); Gunnarsson, I (1); Svenungsson, E (1); Truedsson, L (1); Idborg, H (1); Lehtio, J (1); Elvin, K (1); Jakobsson, P (1); Sandberg, A. (1); Zandian, Arash (1); Mo, J. (1); Sima, Eduardo, Ph.D. ... (1); show less...

University: Uppsala University (4); Royal Institute of Technology (1); Karolinska Institutet (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (4)

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