| 1. |
- Grubb, Anders, et al.
(author)
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Immunohistochemical characterization of the amyloid deposits and quantitation of pertinent cerebrospinal fluid proteins in hereditary cerebral hemorrhage with amyloidosis
- 1987
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In: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 18:2, s. 431-440
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Journal article (peer-reviewed)abstract
- Cystatin C, a protein inhibitor of lysosomal cysteine proteinases, was demonstrated by immunohistochemical techniques to be present in the birefringent amyloid deposits of the small arteries in the cerebrum, cerebellum, and leptomeninges of 10 Icelandic individuals with hereditary cerebral hemorrhage with amyloidosis. Specimens from other organs were investigated in one of the patients, and amyloid angiopathy characterized by an immunoreactivity of cystatin C was found in a submandibular lymph node. No immunoreactivity of amyloid fibril protein AA, kappa or lambda immunoglobulin light chain, or prealbumin was observed. Significantly low cerebrospinal fluid concentrations of cystatin C were found in all 9 investigated individuals with hereditary cerebral hemorrhage with amyloidosis. The concentrations of beta 2-microglobulin, albumin, and IgG in the cerebrospinal fluid were within normal limits. Isoelectric focusing showed that cystatin C from the cerebrospinal fluid of 9 patients with hereditary cerebral hemorrhage with amyloidosis had an isoelectric point identical to that of normal individuals. This investigation demonstrates that hereditary cerebral hemorrhage with amyloidosis may be diagnosed by two laboratory methods: immunohistochemical investigation of cystatin C in brain tissue specimens and quantitation of cystatin C in cerebrospinal fluid.
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| 7. |
- Nilsson, Mats T, et al.
(author)
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SEQ-ED - AN INTERACTIVE COMPUTER-PROGRAM FOR EDITING, ANALYSIS AND STORAGE OF LONG DNA-SEQUENCES
- 1985
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In: COMPUTER APPLICATIONS IN THE BIOSCIENCES. - oxford : Oxford University Press. - 0266-7061. ; 1:1, s. 29-34
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Journal article (peer-reviewed)abstract
- The rapidly growing body of sequenced DNA demands efficient computer programs for its analysis and storage. The program described in this paper, SEQ-ED, has been designed to handle a large number of DNA sequences up to 200 kilobases [kb] long stored in a sequence library. In order to minimize the required storage space, the sequences are stored in a compressed format using three binary digits per base. In the development of this program, special care has been given to make it easy to use for molecular biologists without any previous computer experience.
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| 8. |
- Nilsson, Ove, et al.
(author)
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dc-ac hot-wire procedure for determining thermophysical properties under pressure
- 1986
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In: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 57:9, s. 2303-2309
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Journal article (peer-reviewed)abstract
- The paper describes a new hot‐wire method for simultaneous determination of thermal conductivity and heat capacity per unit volume of electrically insulating liquids and solids under pressure. The method uses dc heating of the hot wire, whereas the temperature increase is recorded by an ac bridge circuit. The temperature data obtained are analyzed using the exact solution instead of the commonly used long time approximation. The procedure was tested on a number of alcohols and water and the accuracy was found to be 1.5%. New data on glycerol up to 1.5 GPa are presented. The appearance of an automagnetoresistance effect when Ni is employed as hot‐wire probe is discussed.
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| 9. |
- Nilsson, Ove, et al.
(author)
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Thermal conductivity of B2O3 glass under pressure
- 1985
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In: International journal of thermophysics. - : Plenum Publishing. - 0195-928X .- 1572-9567. ; 6:3, s. 267-273
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Journal article (peer-reviewed)abstract
- The thermal conductivity, λ, of vitreous boron trioxide was measured, using a hot-wire procedure, from 170 to 570 K and under pressures of up to 1.7 GPa. The thermal conductivity at room temperature and zero pressure was found to be 0.52 W · m−1 · K−1. The values of the logarithmic pressure derivative, g = d(ln λ)/d(ln ρ), where ρ is the density, were found to be 1.1 for uncompacted glass and 0.7 for glass compacted to 1.2 GPa. The variation of λ with temperature at constant density was approximately linear, with a positive slope of 1.38×10−3W·m−1·K−2.
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| 10. |
- Nilsson, Ove, et al.
(author)
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Thermal properties of sulphur under pressure
- 1984
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In: Thermophysical properties. ; , s. 277-283
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Conference paper (peer-reviewed)abstract
- The thermal conductivity, λ, and the heat capacity per unit volume, ρcp, have been measured for sulphur as functions of temperature in the range 140-450 K and under pressures up to 2 GPa. Within these limits sulphur exists in two crystalline phases, apart from amorphous and liquid modifications. The thermal properties have been measured by a refined hot-wire probe method which involves DC heating and AC resistance thermometry. The method yields values for λ and ρcp simultaneously. The experimental results for sulphur are discussed in terms of structural disorder. Evidence for residual thermal resistance in the orthorhombic phase is correlated with recently discovered ultrasonic absorption. This contribution was found to decrease substantially under pressure.
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